Kv1.3 Channel Blockade by Dalfampridine Attenuates NLRP3 Inflammasome-Driven Demyelination via the NEK7/Ripk1/FADD Pathway, Matching the Efficacy of Broad P2X7 Antagonism by Suramin in EAE [0.03%]
二苯甲烷通过Dalfampridine阻断Kv1.3通道可减弱NLRP3炎性小体驱动的脱髓鞘作用，其效果与EAE中硫胺类似物广谱P2X7拮抗相当，通过NEK7/Ripk1/FADD途径实现
Ahmed S Kamel,Heba Nasr Shalaby,Yasmin A M El-Said et al.
Ahmed S Kamel et al.
The loss of intracellular K+ facilitated by different channels such as Panx1, TWIK2, or Kv1.3, is a danger signal that activates programmed cell death in oligodendrocytes via NLRP3 inflammasome and pyroptosis in multiple sclerosis (MS). ATP...
MORC2 Recruits Tumor-Associated Macrophages and Inhibits Pyroptosis Through Activating the Wnt/β-Catenin Pathway in Breast Cancer [0.03%]
MORC2通过激活Wnt/β-catenin信号通路募集肿瘤相关巨噬细胞并抑制乳腺癌的pyroptosis
Zhiyong Liu,Hong Hu,Zhiqin Lin et al.
Zhiyong Liu et al.
Breast cancer (BC), characterized by a high incidence specifically in women, exhibits a complex etiology. This study aims to investigate the role and underlying mechanism of microrchidia CW-type zinc finger 2 (MORC2) in BC progression. MCF-...
Potential Biological Targets of Anticancer Metal-Based Drug Candidates: A Systematic Review [0.03%]
抗癌金属药物候选生物靶点的系统性综述
Allysson L Dos S Ferreira,Bruna B Dantas,Jailton De Souza-Ferrari et al.
Allysson L Dos S Ferreira et al.
The discovery of Cisplatin marked the beginning of the metallodrug era in oncology. Despite their clinical success, platinum-based compounds present important limitations, including drug resistance and systemic toxicity. These challenges ha...
Programmable Poly-Lactic-Co-Glycolic Acid Nanocarriers for Precision Therapy of Pancreatic Ductal Adenocarcinoma [0.03%]
用于精准治疗胰腺导管腺癌的可编程聚乳酸-こ glycolic acid纳米载体
Shruti Gupta,Nazim Nasir,Shadma Wahab et al.
Shruti Gupta et al.
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignancies, characterized by late-stage diagnosis, dense desmoplastic stroma, rapid metastatic progression, and poor responsiveness to conventional chemotherapy. Conseq...
Astragaloside IV Enhances Anti-PD-L1 Immunotherapy in Triple-Negative Breast Cancer by Activating the cGAS-STING Pathway [0.03%]
黄芪苷IV通过激活cGAS-STING通路增强抗PD-L1免疫治疗以治疗三阴性乳腺癌
Chuanchao Wei,Qing Zhang,Anwei Mao et al.
Chuanchao Wei et al.
Astragaloside IV (AS-IV), a natural compound from traditional Chinese medicine, has demonstrated anti-tumor properties. This study aims to explore its potential to enhance anti-mPD-L1 immunotherapy in triple-negative breast cancer (TNBC) by...
Heterocyclic Scaffold Modification of Chalcones: Piperidinyl and Morpholinyl Triazene Derivatives as Potent Blood Stage Antimalarials With SAR and Docking Insights [0.03%]
异环结构改性的查尔康素：哌啶基和吗啉基三唑衍生物作为有效的红细胞期抗疟药及其构效关系和分子对接研究
Ahammed Ameen Thottasseri,Vinoth Rajendran,Deepthi Ramesh et al.
Ahammed Ameen Thottasseri et al.
The emergence of resistance to existing antimalarials, including artemisinin and its combinations, has intensified the need for new chemotypes with improved efficacy. In this study, a scaffold-hopping strategy was employed to design and dev...
Unraveling Key Genes Related to Fatty Acid Metabolism in Neuropathic Pain [0.03%]
揭秘与神经痛相关的脂肪酸代谢关键基因
Ye Wang,Can Liu,Mingfang Wang et al.
Ye Wang et al.
Neuropathic pain (NP), a chronic condition resulting from nerve injury or dysfunction, represents considerable therapeutic difficulties owing to its intricate and multifactorial pathophysiology. Recent studies indicate that dysregulated fat...
Dual-Function Lipid-Based Nanovector Strategy for Glioblastoma Immunotherapy: STING Activation and M1 Microglia Polarization [0.03%]
用于胶质母细胞瘤免疫治疗的双功能脂质基纳米载体策略：STING活化和M1小胶质细胞极化
Mohamed S Nafie,Mohamed Khaled Diab,Sherif Ashraf Fahmy
Mohamed S Nafie
Glioblastoma (GBM) remains one of the most lethal brain malignancies because of its highly immunosuppressive tumor microenvironment and the limited penetration of therapeutics across the blood-brain barrier (BBB). Although recent studies ha...
Wenbo Che,Xinlin Wang,Sijin Chen et al.
Wenbo Che et al.
Proteolysis Targeting Chimera (PROTAC) is a bifunctional small molecule composed of a ligand for the target protein, a ligand for an E3 ubiquitin ligase, and a chemical linker. It induces the formation of a ternary complex between the targe...
Pyrimidine-Derived Scaffolds Targeting VEGFR-2, EGFR, and HER-2: Synthesis, Anticancer/Immunomodulatory Evaluation, and In Silico Analysis [0.03%]
基于嘧啶的血管生成和免疫调节剂研究及机制探讨
Naglaa M Ahmed,Mohamed S Gaballah,Belen Altava et al.
Naglaa M Ahmed et al.
Following the common structural features of VEGFR-2, EGFR, and HER-2 kinase inhibitors, two newly synthesized series of 3,4-dihydropyrimidine 2(1H)-(thio)ones-5-carboxamide (2a-l) and thiouracil-5-sulfonyl derivatives (4a-e) were evaluated ...