Recent Development in Celiac Disease: Pathophysiology, Animal Models and Treatments [0.03%]
最近的乳糜泻研究进展：发病机理、动物模型及治疗方法
Vishal Patel,Amit Joharapurkar,Mukul Jain
Vishal Patel
Celiac disease (CD) is an autoimmune disorder which is triggered by gluten in genetically susceptible individuals. There is no successful therapy for CD. A strict gluten-free diet (GFD) is the only remedy used in clinical practice, which hi...
Sestrin2 Regulates Mitochondrial Function and Autophagy via Nrf2/SIRT3 Signaling to Ameliorate Hypoxia/Reoxygenation-Induced Rat's Cardiomyocyte Injury [0.03%]
Sestrin2通过Nrf2/SIRT3信号调节线粒体功能和自噬以缓解心肌细胞的缺氧/复氧损伤
Tong Liu,Jiajie Kong,Zhaobin Li et al.
Tong Liu et al.
Mitigating myocardial ischemia-reperfusion (I/R) injury poses a significant challenge, necessitating the exploration of novel therapeutic targets. Sestrin2 (Sesn2), a stress-induced protein, has emerged as a potential candidate for attenuat...
Targeting the Enzymatic Site of Botulinum Neurotoxin Type E With 8-Hydroxyquinolinol-Based Inhibitors: In Silico, In Vitro, and In Vivo Evaluation [0.03%]
基于8-羟基喹啉的抑制剂靶向肉毒杆菌素E型酶活性位点：计算、体外和体内评价
Priyanka Sonkar,Vinita Chauhan Kushwah,Surabhi Agnihotri et al.
Priyanka Sonkar et al.
Botulinum neurotoxins are the most potent toxins responsible for causing flaccid paralysis of muscles by blocking the release of acetylcholine at the neuromuscular junction. There are no postexposure therapeutics and effective active/passiv...
Berberine as a Multi-Targeted Therapeutic Agent in Melanoma: Mechanisms, Efficacy, and Combination Therapies [0.03%]
巴马汀作为黑色素瘤的多靶点治疗药物：机制、疗效和联合疗法
Rong-Rong Wang,Hui Wu,Meng-Ling Feng et al.
Rong-Rong Wang et al.
Melanoma is a type of aggressive cancer distinguished by its high propensity for recurrence, the development of metastases, and an unfavorable outlook for recovery. Treatment modalities for melanoma encompass surgery, immunotherapy, and tar...
Space Pharmaceutical Manufacturing: Emergence of a New Era for Pharmaceutical Industry [0.03%]
空间制药制造：制药业新时代的到来
Manali Patel,Anvi Naphade,Priti Mehta
Manali Patel
The space environment, characterized by microgravity and elevated radiation, offers a unique platform for scientific research with transformative potential for biomedical and pharmaceutical industries. As launch costs have decreased and com...
Cationic Lipid Stearylamine Displays Fast-Acting Antimalarial Action Against In Vitro Blood Stages of Chloroquine Susceptible and Resistant Plasmodium falciparum Strains [0.03%]
阳离子脂质十六烷基三甲基溴化铵和十八胺对恶性疟原虫氯喹敏感株和抗性株的体外血期抑制作用及机制研究
Vinoth Rajendran,Keerthana Gurukkalot,Nimitha Cherthedath Naveen
Vinoth Rajendran
The growing resistance of malarial parasites to antiplasmodial drugs has necessitated the development of a new class of potent molecules to reduce the global malaria burden. This study evaluated the antimalarial efficacy of the cationic lip...
Ethyl Linoleate Ameliorates Synovial Cell Proliferation and Inflammatory Cell Infiltration in Rheumatoid Arthritis Through DKK1/Wnt-OPG Signal Axis and Autophagy [0.03%]
乙醇亚油酸通过DKK1/Wnt-OPG信号轴和自噬缓解类风湿关节炎滑膜细胞增生及炎症细胞浸润
Zong Jiang,XiaoLing Yao,Xin Cai et al.
Zong Jiang et al.
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease affecting synovial joints. Jinwu Jiangu Capsules (JJC) has been shown to be effective in treating RA. However, the primary active components and the underlying molecular...
Comparative Study of Pyridine and Pyrimidine Derivatives as Promising Anti-Inflammatory Agents: Design, Synthesis, and LPS-Induced RAW 264.7 Macrophages [0.03%]
吡啶和嘧啶衍生物作为有前景的抗炎剂的比较研究：设计、合成及脂多糖诱导的RAW 264.7巨噬细胞实验研究
Farid M Sroor,Ahmed A F Soliman,Wagdy K B Khalil et al.
Farid M Sroor et al.
In this study, we aimed to design and synthesize a novel series of pyridine and pyrimidine derivatives and evaluate their anti-inflammatory activity against RAW 264.7 macrophages. Using chalcones (5a-f) as suitable precursors, we disclosed ...
Lu Liu,Yubao Li,Tian Mao et al.
Lu Liu et al.
Previous studies have shown that general anesthetics have neurotoxic effects on developing brains. Reducing the toxicity of anesthetics or finding nonneurotoxic anesthetics is a major challenge in anesthetic research. Neuroactive steroids (...
Betulinic Acid Alleviates Acute Pancreatitis by Promoting SIRT1-PINK1-Mediated Mitophagy in Acinar Cells [0.03%]
熊果酸通过促进芽孢杆菌细胞中SIRT1-PINK1介导的线粒体自噬来缓解急性胰腺炎
Zhenfei Yu,Ying Li,Peng An et al.
Zhenfei Yu et al.
Betulinic acid (BA) has the potential to ameliorate acute pancreatitis (AP); however, the mechanisms have not been fully elucidated. This study aimed to identify the effect of BA on mitophagy and its mediated acetylation. Rat pancreatic aci...