Exploring Novel Tetrahydropyrimidine and Fused Pyrimidine-Based Compounds as DHFR Inhibitors and Antimicrobial Agents: Synthesis, In Vitro, In Vivo, and In Silico Studies [0.03%]
作为DHFR抑制剂和抗菌剂的新型四氢嘧啶和稠合嘧啶类化合物的研究：合成，体内外及计算机模拟研究
Menna M Sherif,Basem Mansour,May A El-Antrawy et al.
Menna M Sherif et al.
New series of 2-imino/oxo-tetrahydropyrimidines (4a-4j), and fused pyrimidines (5a-5i and 6a-6h) were designed and synthesized as attractive scaffolds to be investigated in vitro and in vivo for antimicrobial activity against gram-positive ...
Atopic Dermatitis: Updated Insights Into Pathophysiology and Emerging Therapies [0.03%]
特应性皮炎：病理生理更新及新兴疗法
Mei Xie,Lingrui Kong,Guojia Li et al.
Mei Xie et al.
Atopic dermatitis (AD) is a chronic, relapsing skin ailment characterized by intense itching and diverse clinical manifestations. Its pathogenesis is complex, involving genetic, microbial, and immunological factors. Recently, significant th...
Phytol Enhances Anticonvulsant Effect of Carbamazepine and Diazepam Against PTZ-Induced Convulsion in Chicks, Possibly Through Voltage-Gated Sodium Channel and GABAA Interaction Pathways [0.03%]
菖蒲醇通过电压门控钠通道和GABAᴀ受体信号通路增强卡马西平和安定对雏鸡戊四唑诱发惊厥的抗痫作用研究
Md Torequl Islam,Shoyaeb Ahammed,Md Sakib Al Hasan et al.
Md Torequl Islam et al.
The chlorophyll-derived diterpenoid phytol (PHY) is evident for its diverse biological effects, including neuroprotective activities in experimental animals. This study aims at the evaluation of anticonvulsant effects along with the possibl...
Design, Synthesis, and Biological Evaluation of 8-Phenyl-THIQ as Antidepressive Agents [0.03%]
作为抗抑郁剂的设计、合成及生物评估的8-苯基-THIQ类化合物研究
Xiaopeng Wei,Fan Yang,Nuo Xu et al.
Xiaopeng Wei et al.
The structural modification and derivatization of natural products represent an essential pathway for pharmaceutical innovation in the management of depression. The 8-phenyl tetrahydroisoquinoline, as a parent core, was obtained from magnof...
Lazertinib: A Cardio-Safer Alternative to Osimertinib for Epidermal Growth Factor Receptor L858R/T790M Double-Mutant Tyrosine Kinase Resistant Non-Small Cell Lung Cancer [0.03%]
激光替尼：表皮生长因子受体L858R/T790M双突变阳性的非小细胞肺癌患者中奥希替尼后的一种心脏安全性替代治疗方案
Chandrakant S Gawli,Narendra R Nagpure,Bhatu R Patil et al.
Chandrakant S Gawli et al.
Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality, with "epidermal growth factor receptor (EGFR)" mutations playing a pivotal role in tumor progression and carcinogenesis. "Third-generation epidermal gro...
Triazole-Pyrimidine Hybrids as EGFR Inhibitors via Synthesis, In Silico, In Vitro, and In Vivo Evaluation as Anticancer Agents [0.03%]
通过合成、计算机模拟、体外和体内评估的三唑-嘧啶杂环类化合物作为EGFR抑制剂及抗肿瘤制剂的研究
Rahul Dubey,Shankar Gupta,Rajveer Singh et al.
Rahul Dubey et al.
The epidermal growth factor receptor (EGFR) is a common diver gene for lung cancer (NSCLC), which leads to an increasing death rate worldwide. This study reports the design, synthesis, and biological evaluation of triazole-clubbed pyrimidin...
Isolation, Purification, and Preparation of Taxinine-Loaded Liposomes for Improved Anti-Hepatocarcinogenic Activity [0.03%]
分离、纯化和制备 TAXinine 荷载脂质体用于改善抗肝癌作用
Qilong Wang,Xiaowen Wang,Qinyang Hua et al.
Qilong Wang et al.
Liver cancer is the fourth most deadly cancer worldwide, but existing treatment options are insufficient, thus highlighting the urgent need for new therapeutic agents. Taxanes, known for their anticancer properties, provide a promising aven...
Co-Loaded Nanoparticles of Empagliflozin and Rutin for Pancreatitis Prevention and Anticancer Activity [0.03%]
恩格列净和芸香素共载纳米颗粒的胰腺炎预防及抗癌作用研究
Olla Maan,Ali Al-Samydai,Moath Alqaraleh et al.
Olla Maan et al.
Cancer treatment faces challenges like nonselective toxicity and drug resistance, prompting the need for innovative therapies. This study aimed to develop liposomal formulations for co-delivery of empagliflozin and rutin, evaluating their a...
Theaflavins Inhibit Proliferation and Glycolysis of Colorectal Cancer Cells by Downregulating DDIT4 [0.03%]
茶黄素通过下调DDIT4抑制结直肠癌细胞增殖和糖酵解
Huanqing Li,Songhua Bei,Yanqing Mo et al.
Huanqing Li et al.
Colorectal cancer (CRC) is a common malignancy often characterized by metastasis and poor prognosis. This study attempts to ascertain the anticancer impacts of theaflavin (TF) on CRC cells and examine the fundamental molecular mechanisms, f...
Exploring the Topoisomerase II Inhibitory Potential of Steroidal Drugs as a Recommended Mechanism of Action for Their Anticancer Activity: In Silico and In Vitro Assessments [0.03%]
用于抗癌活性的推荐机制作用的甾族药物拓扑异构酶II抑制潜能的研究：基于计算和实验的方法评估
Ahmed A Al-Karmalawy,Mohamed E Eissa,Ayman Abo Elmaaty et al.
Ahmed A Al-Karmalawy et al.
Herein, and based on the pharmacophoric features of doxorubicin (Dox); 133 steroids were screened to assess their ability to act as TOP II inhibitors for the discovery of those with promising anticancer activity. The cytotoxic inhibitory co...