Rational Discovery of BACE1-Selective Inhibitors as Potential Therapeutics for Alzheimer's Disease [0.03%]
合理发现BACE1特异性抑制剂作为阿尔茨海默病的潜在治疗药物
Tanmaykumar Varma,Pradnya Kamble,Prabha Garg
Tanmaykumar Varma
Alzheimer's disease (AD) remains a major neurodegenerative disorder with limited therapeutic medication. Despite intensive efforts, the clinical development of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors has been ...
Synthesis, Biological Evaluation and Molecular Docking Studies of New 4-(Cyanomethyl)-N'-Substituted Benzohydrazide Derivatives as Anti-Alzheimer Agents [0.03%]
新的4-（氰甲基）-N'-取代苯并肼衍生物作为抗阿尔茨海默剂的合成、生物评价和分子对接研究
Fatih Tok,Nimet Baltaş,Burçin İrem Abas et al.
Fatih Tok et al.
Although the incidence of Alzheimer's disease increases with age, the number of effective drugs in the fight against this disease remains insufficient. In this regard, a new series of hydrazide-hydrazone derivative compounds (3a-3n) was syn...
Oleuropein Modulates Mitophagy and Metabolism in Cardiomyocyte Via the PINK1/Parkin Signaling Pathway [0.03%]
橄榄苦素通过PINK1/Parkin信号通路调节心肌细胞的线粒体自噬和代谢反应
Hao Ling,Chunli Song
Hao Ling
Oleuropein (OLEU), a natural polyphenol, exhibits cardioprotective potential through mitochondrial modulation, yet its precise mechanisms remain elusive. This study elucidates OLEU's role in alleviating oxidative stress and regulating mit...
Pyrrolidine-2-carbonitrile Derivatives as Multifunctional Antidiabetic Agents: Inhibition of α-Amylase, α-Glucosidase, and DPP-IV With Structure-Activity Relationships, HSA Binding, and Molecular Docking Studies [0.03%]
吡咯烷-2-腈衍生物作为多功能抗糖尿病药物：α-淀粉酶、α-糖苷酶和DPP-IV抑制剂的结构活性关系、HSA结合及分子对接研究
Aeyaz Ahmad Bhat,Iqubal Singh
Aeyaz Ahmad Bhat
A series of pyrrolidine-2-carbonitrile derivatives was designed, synthesized, and evaluated for their antidiabetic potential. The synthesized compounds exhibited notable inhibitory activity, with IC₅₀ values ranging from 9.36 to 21.54 µg...
Antiproliferative Effects of the Triterpene Ursolic Acid Natural Product in Bladder and Ovarian Tumor Cell Lines [0.03%]
乌索酸对膀胱和卵巢肿瘤细胞系的抗增殖作用
Lídia Walter de Paula E Silva,Tamires Cunha Almeida,Mariane Ster da Silva Teixeira et al.
Lídia Walter de Paula E Silva et al.
Bladder and ovarian cancers impose a significant burden on healthcare systems due to their high incidence, mortality rates, and the challenges associated with early diagnosis. Current chemotherapy regimens, which typically involve combinati...
Neuroprotective Effects of Liraglutide and/or Rivastigmine Combination on the Rat Hippocampus [0.03%]
利拉鲁肽和/或石杉碱甲对大鼠海马的神经保护作用研究
Raafat A Abdel-Aal,Mohammad Salem Hareedy,Dalia M Badary et al.
Raafat A Abdel-Aal et al.
This study evaluated the neuroprotective potential of a combination therapy using liraglutide (LIRA), an antidiabetic agent, and rivastigmine (RIVA), a standard treatment for Alzheimer's disease (AD), in a rat model of aluminum chloride (Al...
Scopoletin Mitigates DSS-Induced Ulcerative Colitis by Attenuating NF-κB/MMP-9 Mediated Inflammation and Activating the Nrf2 Pathway to Preserve Colonic Barrier Integrity [0.03%]
scopoletin通过抑制NF-κB / MMP-9介导的炎症并激活Nrf2通路来维持结肠屏障完整性从而缓解DSS诱导的溃疡性结肠炎
A Gowtham,Tushar Mishra,Tarh Gungha et al.
A Gowtham et al.
Ulcerative colitis (UC) is a chronic inflammatory disorder of the colon, characterized by persistent mucosal inflammation and epithelial barrier disruption. This study investigated the therapeutic efficacy of Scopoletin, a natural coumarin ...
Nanoparticle-Integrated Transdermal Patches: A Platform for Next-Generation Drug Delivery [0.03%]
纳米颗粒透皮贴片：下一代药物传输平台
Neethi Mohan,Remya Prabhavathi Amma Neelakandan Nair,Damodharan Narayanasamy
Neethi Mohan
Nanoparticle-mediated transdermal systems can bypass the skin's natural outer barrier (stratum corneum), allowing drugs to enter the body more effectively. This technology improves how much drug reaches the bloodstream and how long it acts,...
Design, Synthesis, and 2D QSAR Analysis of Some Novel Pyrazolo[1,5-a]pyrimidine Derivatives as Pim-1 Kinase Inhibitors for the Treatment of MCF-7 Breast Cancer [0.03%]
设计、合成及一些新型吡唑并[1,5-a]嘧啶衍生物作为Pim-1激酶抑制剂用于治疗MCF-7乳腺癌的2D QSAR分析研究
Esraa Z Mohammed,Nehad M El-Dydamony,Ahmed B M Mehany et al.
Esraa Z Mohammed et al.
In the current study, new pyrazolo [1,5-a]pyrimidine-3-carbonitriles were synthesized and evaluated for their inhibitory activity against Pim-1 kinase. The most potent inhibitors were 4d, 5d, and 9a with IC50 values (0.61, 0.54 and 0.68 μM...
CCAR2 Drives Glioma Cell Survival by Positively Regulating SIRT1 and Activating the Notch1/c-Myc Pathway [0.03%]
CAR2通过正向调节SIRT1及激活Notch1/c-Myc通路来调控胶质瘤细胞的存活功能
Lan Ma,Chun Liu,Yi Zhang et al.
Lan Ma et al.
Cell cycle and apoptosis regulator 2 (CCAR2) is a transcriptional regulator involved in diverse types of cancer. However, its role in human glioma is unclear. This study aimed to investigate whether CCAR2 could function as a regulator in gl...