Ferroptosis in Cholangiocarcinoma Therapy: Molecular Mechanisms, Pharmacological Modulation and Opportunities for Drug Development [0.03%]
胆管癌治疗中铁死亡的分子机制、药理学调控及药物开发机遇
Hafsa Athar,Sabahat Zulfiqar,Arslan Ali et al.
Hafsa Athar et al.
Cholangiocarcinoma (CCA) is a type of cancer that has a rather high mortality rate and arises from cholangiocytes. Due to its aggressive nature, CCA is considered a rare and highly advanced form of malignancy. This research is detailed arou...
Reprogramming the Tumor Microenvironment: Calebin A as a Polyphenolic Paradigm Shift in Controlling Inflammation, Stemness, and Resistance in Colorectal Cancer [0.03%]
肿瘤微环境的再编程：Calebin A 作为结直肠癌控制炎症、干细胞和耐药性的多酚范例转变
Abdullah A Alshehri,Wael Y Khawagi
Abdullah A Alshehri
Colorectal cancer (CRC) remains a leading cause of cancer mortality worldwide, largely due to inflammation-driven progression, cancer stemness, and multidrug resistance (MDR). The tumor microenvironment (TME) orchestrates these hallmarks th...
From Cancer to Neuroprotection: Pazopanib Modulates the RIPK1/RIPK3/MLKL and PGAM5/DRP1 Pathways in 3- Nitropropionic Acid-Induced Huntington's Disease [0.03%]
从癌症到神经保护：帕唑帕尼调节3-硝基丙酸诱导的亨廷顿病中的RIPK1/RIPK3/MLKL和PGAM5/DRP1通路
Muhammad A Eltarzy,Mostafa A Rabie,Rabab H Sayed et al.
Muhammad A Eltarzy et al.
Huntington's disease (HD) is a progressive neurodegenerative disorder with a poorly understood neurobiological basis. Among the various forms of programmed cell death implicated in neurodegeneration, necroptosis has recently garnered signif...
Thioxo-Based Kojic Acid Derivatives as Potent Tyrosinase Inhibitors With Antitubercular and Antidermatophytic Potential [0.03%]
基于噻肟的曲酸衍生物作为有效的酪氨酸酶抑制剂用于抗结核和抗皮真菌潜在应用
Gülşah Karakaya,Suat Sari,Fatma Sezer Senol Deniz et al.
Gülşah Karakaya et al.
A novel series of sulfur-containing analogs derived from the 3-hydroxy-6-methyl-2-((4-phenylpiperazin-1-yl)methyl)-4H-pyran scaffold was synthesized. Spectroscopic techniques and elemental analysis confirmed their structures. The biological...
Discovery of Bufalin as a Molecular Glue Degrader of NCAPG to Inhibit the Proliferation of Hepatoma Cells [0.03%]
bufalin作为ncapg分子胶降解剂抑制肝癌细胞增殖的发现
Chenghua Wu,Xiaobin Zhuo,Jianxin Yang et al.
Chenghua Wu et al.
Inhibiting the malignant proliferation is crucial for managing the cancer progression. NCAPG (Non-SMC condensin I complex subunit G) is a main component in cell proliferation, which is highly expressed in liver tumors and negatively correla...
TNFRSF17 Knockdown Alleviates Mitochondrial Dysfunction and Inflammation in COPD Through Suppression of the JAK2/STAT3 Pathway [0.03%]
TNFRSF17敲低通过抑制JAK2 / STAT3途径缓解慢性阻塞性肺疾病中的线粒体功能障碍和炎症反应
Xiaomei Yang,Yuwen Huang,Aifang Zheng et al.
Xiaomei Yang et al.
Mitochondrial dysfunction is a hallmark of chronic obstructive pulmonary disease (COPD). Nevertheless, the precise molecular mechanisms of COPD have yet to be fully elucidated. Protein-protein interaction (PPI) network construction and weig...
Targeting of PCSK9 in the Management of Alzheimer's Disease: Expanding the New Potential Key Player [0.03%]
靶向PCSK9在阿尔茨海默病管理中的作用：新兴关键因素的新潜力探索
Mansour Alanazi,Hayder M Al-Kuraishy,Nawar R Hussain et al.
Mansour Alanazi et al.
Alzheimer's disease (AD) represents the most common cause of dementia in the elderly population worldwide. However, most of the anti-AD medications did not resolve the underlying neuropathology. Consequently, targeting other signaling pathw...
Jiaming Guo,Tongfu Yang,Dingling Li et al.
Jiaming Guo et al.
Breast cancer remains one of the leading causes of mortality among women worldwide, and triple-negative breast cancer continues to show poor clinical outcomes due to the absence of actionable targets. As platinum-based therapies face well-r...
Beyond the Forest Plot: Redefining Model-Based Meta-Analysis as a Quantitative Engine for Model-Informed Drug Development [0.03%]
超越森林图：重新定义基于模型的meta分析作为模型指导下的药物研发的定量引擎
Bhavatharini Sukumaran,Rinu Mary Xavier,Aswathy Vs et al.
Bhavatharini Sukumaran et al.
Despite the fact that meta-analysis is a widely utilized methodology in synthesis of evidence from clinical trials, traditional methodologies have limitations with regards to informing dose selection, time-course dynamics and quantitative d...
Exploring CPP Enhanced Hypoxia Targeting: An Approach Using Radiolabeled 2-nitroimidazole TAT Conjugate [0.03%]
利用放射性标记的2-硝基咪唑-TAT缀合物探索CPP增强型低氧靶向作用
Sweety Mittal,Akanksha Jain,Ashwini Babu et al.
Sweety Mittal et al.
Mediated by their protein transduction domain, cell-penetrating peptides (CPPs) have been widely explored for facilitating intracellular delivery of drugs and small molecules. In this study, a radiolabeled, 2-nitroimidazole conjugated TAT (...