From Sulfa Drugs to New Antibacterial Agents: Advances in Chemical Modification of Approved Sulfonamides [0.03%]
从磺胺类药物到新型抗菌剂：已批准磺酰胺类化合物的化学修饰进展
Ayşe Karagüzel,Ebru Koçak Aslan,Miyase Gözde Gündüz
Ayşe Karagüzel
Sulfonamides, the oldest synthetic antibacterial agents, specifically target the enzyme dihydropteroate synthase (DHPS), which is essential for the folic acid biosynthesis pathway. In contrast, humans do not use this mechanism as they produ...
Babatunde Ibrahim Olowu,Maryam Ebunoluwa Zakariya,Abdulmuheez Abiola Abdulkareem et al.
Babatunde Ibrahim Olowu et al.
Intracellular bacteria exploit host cell niches, such as lysosomes, phagosomes, cytosol, entire cells, and even erythrocytes, to evade immune clearance and escape conventional antibiotics. These environments pose numerous therapeutic challe...
Exploration Novel of Pyrazole and Isoxazole Derivatives as Potential Antimicrobial Agents: Design, Synthesis, Structure Activity Relationship Study, and Antibiofilm Activity With Molecular Docking Simulation [0.03%]
咪唑和异噁唑衍生物作为潜在抗菌剂的探索：设计、合成、结构活性关系研究及抗生物膜作用与分子对接模拟
Khadija E Saadon,Ahmed Ragab,Nadia M H Taha et al.
Khadija E Saadon et al.
Developing new antimicrobial drugs is crucial for combating global drug resistance caused by microbial infections. Here, a new series of pyrazole and isoxazole derivatives were synthesized using a multicomponent reaction based on ethylvanil...
Leveraging the Fragment Merging Approach for Synthetizing Novel Selanyl Phenyl Acetamide Thiazolidinedione Hybrids Endowed With Apoptotic Potential for Cancer Treatment [0.03%]
一种新型苯基丙氨噻唑并二酮片段合并合成方法及其诱导癌细胞凋亡的潜能研究
Saad Shaaban,Ayman Abo Elmaaty,Aya Yaseen Mahmood Alabdali et al.
Saad Shaaban et al.
Designing novel selenium-containing compounds (organoselenium compounds, OSe) has shown growing interest owing to their chemoprotective and antioxidant properties. Consequently, by harnessing a fragment merging approach, a series of novel O...
Enzyme Responsive Magnetic Nanoparticles for Targeted Drug Delivery and Precision Medicine [0.03%]
基于酶响应的磁性纳米药物载体用于精准医疗及靶向给药治疗
Zhenchen Du,Ebraheem Abdu Musad Saleh,M M Moharam et al.
Zhenchen Du et al.
Enzyme-responsive magnetic nanoparticles (MNPs) represent an emerging class of multifunctional drug delivery systems that combine spatial precision with biochemical selectivity. By integrating magnetic guidance with enzyme-triggered activat...
Exploring Artificial Intelligence's Potential to Enhance Conventional Anticancer Drug Development [0.03%]
探究人工智能在增强传统抗癌药物开发潜力方面的应用
Sorin-Ștefan Bobolea,Miruna-Ioana Hinoveanu,Andreea Dimitriu et al.
Sorin-Ștefan Bobolea et al.
Cancer affects one in three to four people globally, with over 20 million new cases and 10 million deaths annually, projected to rise to 35 million cases by 2050. Developing effective cancer treatments is crucial, but the drug discovery pro...
Emerging in Diabetic Cardiomyopathy: Molecular Pathways and Targets for Therapeutic Intervention [0.03%]
糖尿病心肌病的分子通路及治疗靶点不容忽视
Mansi Vinodkumar Trivedi,Hemant R Jadhav,Anil Bhanudas Gaikwad
Mansi Vinodkumar Trivedi
Amongst various complications presented by diabetes, diabetic cardiomyopathy (DCM) is one of the most prominent and vexing complications. Due to the absence of consensus on prevention and treatment strategies, along with limitations in curr...
Integration of Machine Learning, Bioinformatics, and Experimental Validation to Identify Novel Diagnostic and Prognostic Biomarkers Associated With Succinylation in Lung Adenocarcinoma [0.03%]
集成机器学习、生物信息学和实验验证以识别与肺腺癌乙酰化相关的新型诊断和预后生物标志物
Sixuan Wu,Junfan Pan,Yaqin Zheng et al.
Sixuan Wu et al.
Lung adenocarcinoma (LUAD) is the most prevalent and lethal subtype of non-small cell lung cancer (NSCLC), with its progression closely associated with aberrant succinylation modifications. This study aimed to systematically identify succin...
Kaurenoic Acid Suppresses Osteosarcoma Progression by Reprogramming Tumor-Associated Macrophages to M1 Phenotype [0.03%]
虎杖酸通过重新编程肿瘤相关巨噬细胞为M1表型来抑制骨肉瘤进展
Yingzhen Tang,Yongqi Guo,Yaru Wu et al.
Yingzhen Tang et al.
Osteosarcoma (OS) is the most prevalent primary malignant bone tumor. M2 type tumor-associated macrophages (TAMs) are the predominant infiltrating cells within the OS microenvironment and play a key role in promoting OS progression. Althoug...
CRISPR Targeting the 5' Regulatory Region of FOXM1 Will Also Disrupt RHNO1 [0.03%]
利用CRISPR针对FOXM1的5'调控区也将破坏RHNO1
Adam R Karpf,Niphat Jirapongwattana
Adam R Karpf