Naphthalene-4H-Chromene Molecular Hybrids as Dual Cholinesterase Inhibitors for the Treatment of Alzheimer's Disease [0.03%]
用于阿尔茨海默病治疗的双乙酰胆碱酯酶抑制剂萘酚稠合色满类分子杂化物
Vinod Ugale,Nissi Sharon,Chandradip Salunkhe et al.
Vinod Ugale et al.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline associated with cholinergic dysfunction. Herein, we have designed and synthesized series of 4-(naphthalen-1-yl)-4H-chromene derivatives ...
Identification of Sulfonamide-Based Thiazolidine-2,4-Dione Derivatives as VEGFR-2 and Tumor-Associated hCA IX Inhibitors With Hypoxia-Targeted Anti-Colorectal Cancer Activity [0.03%]
基于磺酰胺的噻唑烷二酮衍生物作为VEGFR-2和肿瘤相关hCA IX抑制剂的鉴定，用于低氧靶向抗结直肠癌活性
Haytham O Tawfik,Mohammed A Dahab,Mohamed R Elnagar et al.
Haytham O Tawfik et al.
Given their critical roles in tumor progression and hypoxia adaptation, concurrent inhibition of carbonic anhydrase IX (hCA IX) and vascular endothelial growth factor receptor-2 (VEGFR-2) is a viable therapeutic approach. This study rationa...
Bacterial mRNA Vaccines: Programming Immunity Against Antimicrobial Resistance [0.03%]
细菌mRNA疫苗：对抗抗生素耐药性的免疫编程
Rui Liao,Mingxing Luo,Fating Yang et al.
Rui Liao et al.
The relentless rise of antimicrobial resistance poses a critical threat to global health, urgently demanding the development of antibacterial vaccines. Messenger RNA (mRNA) technology, validated during the COVID-19 pandemic, offers a powerf...
Identification of Quinoline Tethered Thiadiazole/Thiazole Derivatives as Potent Tyrosinase Inhibitors With Promising Anti-Toxoplasma gondii Agents: Design, Synthesis, and Computational Analysis [0.03%]
基于设计和合成的抗酪氨酸酶及抑制弓形虫的喹啉-噻二唑/噻唑类衍生物的活性研究
Ahmed Sabt,Maciej Chyb,Aladdin M Srour et al.
Ahmed Sabt et al.
Toxoplasmosis, caused by the protozoan parasite Toxoplasma gondii, remains a serious global health concern, largely because current treatments with sulfonamides and pyrimethamine are toxic and increasingly ineffective due to rising drug res...
Selenium-Containing 1,4-Naphthoquinone Derivatives Trigger Reactive Oxygen Species and Apoptosis in Triple-Negative Breast Cancer Cells [0.03%]
含硒的1,4-萘醌衍生物可通过触发活性氧和诱导三阴性乳腺癌细胞凋亡来抑制肿瘤生长
Eduardo Angulo-Elizari,Asif Raza,Hannah Johnson et al.
Eduardo Angulo-Elizari et al.
Cancer ranks as a leading cause of death worldwide, demanding new affordable therapies. Nature offers a diverse array of bioactive scaffolds, including 1,4-naphthoquinone, which serves as a precursor for numerous natural and synthetic compo...
A Medicinal Chemistry Perspective on Anticonvulsant Drug Design: Targets, Mechanisms, and Spiro Compounds [0.03%]
从药物设计角度看抗癫痫的机制、靶点和新型螺环化合物的研究进展
Ghada Abdel Hamid,Ghada F Elmasry,Samir M El-Moghazy et al.
Ghada Abdel Hamid et al.
The neurological condition known as epilepsy is typified by frequent, unprovoked seizures brought on by aberrant or excessive synchronized neuronal activity in the brain. It can arise from various causes, including brain injury, tumors, inf...
Structure-Based Identification and Synthesis of Benzimidazole Azo-Schiff Base Derivatives as Recommended CK2 and PIM-1 Inhibitors [0.03%]
基于结构的苯并咪唑偶氮席夫碱衍生物作为推荐的CK2和PIM-1抑制剂的鉴定与合成
Huda F Hassan,Mohamed E Eissa,Maha Salih Hussein et al.
Huda F Hassan et al.
Casein Kinase-2 (CK2) and Proviral Integration site for Moloney murine leukemia virus-1 (PIM-1) are kinases that are continuously active and work together to promote oncogenesis, thus becoming an important target for anti-cancer drugs. This...
Harnessing the Ocean's Power: Fucoidan as a Novel Neuroregenerative Agent [0.03%]
海洋的力量：褐藻胶作为新型神经再生剂
Qingyuan Wu,Xiangqi Hui,Aoyun Cui et al.
Qingyuan Wu et al.
Neurological disorders, characterized by progressive neuronal loss and functional decline, pose a formidable challenge to global health due to the lack of effective therapies. Fucoidan, a class of fucose-rich sulfated polysaccharides derive...
Entacapone Ameliorates MASLD by Inhibiting FTO Demethylase Activity [0.03%]
恩塔卡朋通过抑制FTO脱甲基酶活性改善MASLD
Sunita Giri,Deepti Sharma,Vijay Kumar
Sunita Giri
MASLD is a chronic liver disease characterized by excess fat build up in the liver. Elevated expression of FTO has been implicated in steatosis and MASLD development. There is no standard treatment for MASLD. Here we investigated the hepato...
Tramiprosate, the Active Agent of ALZ-801, Modulates Amyloidogenic APP Processing and Tau Phosphorylation in a Cellular Model of Alzheimer's Disease [0.03%]
tramiprosate（ALZ-801的有效成分）在阿尔茨海默病细胞模型中调节淀粉样前体蛋白的淀粉样生成性加工及tau磷酸化作用
Kevser Biberoglu,Ozden Tacal
Kevser Biberoglu
ALZ-801, a valine-conjugated prodrug of tramiprosate, has recently been evaluated in a Phase III trial as a potential Alzheimer's disease (AD)-modifying therapy. Tramiprosate reduces misfolding of amyloid beta (Aβ) monomers and inhibits ol...