Interpretation of in vitro concentration-response data for risk assessment and regulatory decision-making: Report from the 2022 IWGT quantitative analysis expert working group meeting [0.03%]
体外浓度-效应数据的风险评估与管理决策解读：定量分析专家工作组会议报告（2022年IWGT）
Marc A Beal,Guangchao Chen,Kerry L Dearfield et al.
Marc A Beal et al.
Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non-animal approaches can be human-relevant alternatives. There is an urgent need to build confid...
The aryl hydrocarbon receptor (AhR) activation mediates benzo(a)pyrene-induced overexpression of AQP3 and Notch1 in HaCaT cells [0.03%]
芳烃受体（AhR）激活介导苯并（a）芘诱导的AQP3和Notch1在HaCaT细胞中的高表达
Claudia I Almendarez-Reyna,Carlos Gabriel de la Trinidad Chacón,Ángeles C Ochoa-Martínez et al.
Claudia I Almendarez-Reyna et al.
The aim of this study was twofold: (1) evaluate the effect of benzo[a]pyrene (BaP) on expression levels of AQP3 and Notch1 genes in HaCaT cells exposed "in vitro" and (2) investigate the possible biological role of assessed genes by bioinfo...
Clonality, trafficking, and molecular alterations among Hprt mutant T lymphocytes isolated from control mice versus mice treated with N-ethyl-N-nitrosourea [0.03%]
有关N-乙基-N-亚硝脲处理的小鼠与对照小鼠T淋巴细胞中Hprt突变克隆的分离、转移及分子改变的研究
Stephen A Judice,Hillary E Sussman,Dale M Walker et al.
Stephen A Judice et al.
Mutations in T lymphocytes (T-cells) are informative quantitative markers for environmental mutagen exposures, but risk extrapolations from rodent models to humans also require an understanding of how T-cell development and proliferation ki...
In vivo genotoxicity testing strategies: Report from the 8th International Workshop on Genotoxicity Testing (IWGT) [0.03%]
第八届国际致突变试验工作组（IWGT）关于体内遗传毒性检测策略的报告
Carol Beevers,Yoshifumi Uno,Krista Meurer et al.
Carol Beevers et al.
The in vivo working group (WG) considered three topics: acceptable maximum doses for negative erythrocyte micronucleus (MN) tests, validation status of MN assays in non-hematopoietic tissues, and nuisance factors in the comet assay. The WG ...
Rachel Lawrence,Kathryn Munn,Hamsa Naser et al.
Rachel Lawrence et al.
The blood cell phosphatidylinositol glycan class A (PIG-A) gene mutation assay has been extensively researched in rodents for in vivo mutagenicity testing and is now being investigated in humans. The PIG-A gene is involved in glycosyl phosp...
Assessment of the in vivo genotoxic potential of three smoke flavoring primary product mixtures [0.03%]
三种烟熏香料原产品混合物的体内致基因毒性评估
Chad M Thompson,Gregory Brorby,Zena Keig-Shevlin et al.
Chad M Thompson et al.
Smoke flavorings are mixtures generated from wood pyrolysis that are filtered to remove tar and are often considered healthier alternatives to conventional smoking processes. While the latter is mostly unregulated, smoke-flavoring primary p...
Genotoxicity assessment in HepaRG™ cells as a new approach methodology follow up to a positive response in the human TK6 cell micronucleus assay: Naphthalene case study [0.03%]
用人TK6细胞微核试验阳性的化合物进行肝毒性评价——用苊为例的新方法学研究
Leslie Recio,Jasmine Fowler,Lincoln Martin et al.
Leslie Recio et al.
We are evaluating the use of metabolically competent HepaRG™ cells combined with CometChip® for DNA damage and the micronucleus (MN) assay as a New Approach Methodology (NAM) alternative to animals for follow up genotoxicity assessment to...
The association of epidermal growth factor variant with oral squamous cell carcinoma [0.03%]
表皮生长因子变异型与口腔鳞状细胞癌的关联研究
Baris Ertugrul,Amal Mohammed,Goksu Kasarci et al.
Baris Ertugrul et al.
In this study, our aim was to investigate the epidermal growth factor (EGF) and epidermal growth factor receptor (EGFR) gene polymorphisms in oral squamous cell carcinoma (OSCC) patients and non-OSCC healthy controls. This case-control stud...
Oxidative DNA damage on the VEGF G-quadruplex forming promoter is repaired via long-patch BER [0.03%]
氧化DNA损伤在VEGF G-四链体形成启动子上的修复是通过长补丁BER完成的
Adil S Hussen,Haley L Kravitz,Bret D Freudenthal et al.
Adil S Hussen et al.
In response to oxidative damage, base excision repair (BER) enzymes perturb the structural equilibrium of the VEGF promoter between B-form and G4 DNA conformations, resulting in epigenetic-like modifications of gene expression. However, the...