Mutagenicity evaluation of methyl tertiary- butyl ether in multiple tissues of transgenic rats following whole body inhalation exposure [0.03%]
全身吸入暴露甲基叔丁醚转基因大鼠多种组织的致突变性评价
B Bhaskar Gollapudi,Erik K Rushton
B Bhaskar Gollapudi
Methyl tertiary-butyl ether (MTBE) is used as a component of motor vehicle fuel to enhance combustion efficiency and to reduce emissions of carbon monoxide and nitrogen oxides. Although MTBE was largely negative in the in vitro and in vivo ...
Mutation spectra of the BRCA1/2 genes in human breast and ovarian cancer and germline [0.03%]
BRCA1/2基因在人类乳腺癌和卵巢癌及生殖细胞中的突变谱型分析
Yumiko Koi,Arisa Watanabe,Akari Kawasaki et al.
Yumiko Koi et al.
Annotating genomic sequence alterations is sometimes a difficult decision, particularly in missense variants with uncertain pathogenic significance and also in those presumed as germline pathogenic variants. We here suggest that mutation sp...
Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT) [0.03%]
第八届国际致突变试验 workshop 关于在毒理学风险评估中将基因突变作为终点的严重性考虑意见书：影响严重性的考量——关于在毒理学风险评估中将基因突变作为终点的意见书（第八届国际致突变工作组研讨会报告）
Barbara L Parsons,Marc A Beal,Kerry L Dearfield et al.
Barbara L Parsons et al.
Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose-response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An "effect severity" AF (ESAF) is employed in so...
Establishment of a nonradioactive DNA ligation assay and its applications in murine tissues [0.03%]
一种非放射性DNA连接检测方法的建立及其在小鼠组织中的应用
Sharleen Friese,Tom Heinze,Franziska Ebert et al.
Sharleen Friese et al.
As final process of every DNA repair pathway, DNA ligation is crucial for maintaining genomic stability and preventing DNA strand breaks to accumulate. Therefore, a method reliably assessing DNA ligation capacity in protein extracts from mu...
Visualization strategies to aid interpretation of high-dimensional genotoxicity data [0.03%]
高维基因毒性数据的可视化解释策略
Stephen D Dertinger,Erica Briggs,Yusuf Hussien et al.
Stephen D Dertinger et al.
This article describes a range of high-dimensional data visualization strategies that we have explored for their ability to complement machine learning algorithm predictions derived from MultiFlow® assay results. For this exercise, we focu...
Assessment of the genotoxicity of tert-butyl alcohol in an in vivo thyroid comet assay [0.03%]
叔丁醇甲状腺彗星试验的体内遗传毒性评估
Chad M Thompson,Nicole Dewhurst,Dmitri Moundous et al.
Chad M Thompson et al.
Chronic exposure to high (20,000 ppm) concentrations of tert-butyl alcohol (TBA) in drinking water, equivalent to ~2100 mg/kg bodyweight per day, is associated with slight increases in the incidence of thyroid follicular cell adenomas and c...
Comparison between inhalational anesthetics in terms of DNA damage and immunological markers [0.03%]
吸入麻醉药的比较：DNA损伤和免疫学标志物方面
Mariana G Braz,Mariane A P Silva,Carlos E Scorza et al.
Mariana G Braz et al.
This study compared genetic damage and immunological markers between surgical patients who underwent inhalational anesthesia with isoflurane or sevoflurane. Blood samples were collected from surgical patients (n = 18 in the isoflurane group...
Comparative Study
Environmental and molecular mutagenesis. 2024 Mar-Apr;65(3-4):137-142. DOI:10.1002/em.22600 2024
Within-laboratory reproducibility of Ames test results: Are repeat tests necessary? [0.03%]
氨氏试验结果的实验室内部可重复性：重复试验有必要吗？
Errol Zeiger,Constance A Mitchell,Stefan Pfuhler et al.
Errol Zeiger et al.
The Ames test is required by regulatory agencies worldwide for assessing the mutagenic and carcinogenic potential of chemical compounds. This test uses several strains of bacteria to evaluate mutation induction: positive results in the assa...
AOP report: Development of an adverse outcome pathway for deposition of energy leading to cataracts [0.03%]
AOP报告：能量沉积导致白内障的不良结局路径构建
Emma Carrothers,Meghan Appleby,Vita Lai et al.
Emma Carrothers et al.
Cataracts are one of the leading causes of blindness, with an estimated 95 million people affected worldwide. A hallmark of cataract development is lens opacification, typically associated not only with aging but also radiation exposure as ...
Inspiring basic and applied research in genome integrity mechanisms: Dedication to Samuel H. Wilson [0.03%]
致敬Samuel H. Wilson教授、激励基因组稳定性机制的基础及应用研究
Shan Yan,Shobhan Gaddameedhi,Robert W Sobol
Shan Yan
This Special Issue (SI) of Environmental and Molecular Mutagenesis (EMM), entitled "Inspiring Basic and Applied Research in Genome Integrity Mechanisms," is to update the community on recent findings and advances on genome integrity mechani...