Identifying Gene Predictors of Chemicals Linked With Breast Cancer: A Machine Learning Analysis of MCF7 Cellular Transcriptomic Screening Data [0.03%]
基于MCF7细胞转录组筛选数据的乳腺癌相关化学物质基因预测因子识别分析研究机器学习
Lauren E Koval,Richard Judson,Julia E Rager
Lauren E Koval
Breast cancer is the most prevalent cancer in women and has been linked to exposure to environmental chemicals. However, many chemicals have not been evaluated for relationships with this outcome. In this study, we analyzed RNA sequencing d...
Vinita Chauhan,Veronica S Grybas,Devyn Hoopfer et al.
Vinita Chauhan et al.
Long-duration spaceflight exposes astronauts to various stressors that can alter human physiology, potentially causing immediate and long-term health effects. These stressors can damage biomolecules, cells, tissues, and organs, leading to a...
Mariane A P Silva,Mónica Cappetta,Tony F Grassi et al.
Mariane A P Silva et al.
Millions of healthcare professionals are occupationally exposed to waste anesthetic gases (WAGs) worldwide; however, their effect on DNA methylation is unknown. Thus, for the first time, global DNA methylation analysis was performed in addi...
David M DeMarini
David M DeMarini
The 10 Key Characteristics of Carcinogens (KCs) were developed by the International Agency for Research on Cancer (IARC) as a framework for organizing mechanistic data for evaluating agents as potential human carcinogens. They emerged from ...
Colemanite Attenuates Metaflumizone-Mediated Hematic/Hepatic Inflammation and DNA Damage in Oncorhynchus mykiss [0.03%]
Colemanite缓解Colemanite引起的Oncorhynchus mykiss血源性/肝源性炎症和DNA损伤Metaflumizone介导的奥尼科林ymphis mykiss血症/肝炎和DNA损伤
Muhammed Atamanalp,Adem Karaman,Arzu Ucar et al.
Muhammed Atamanalp et al.
This study was arranged to assign the LC50 value and effects of metaflumizone (MFZ) in Oncorhynchus mykiss blood/liver tissue with a multibiomarker approach. In addition, the positive/negative responses of the colemanite (COL) substance for...
Decoding the Impact of Genetic Polymorphisms in Xenobiotic Metabolizing Enzymes and Ovarian Cancer: A Comprehensive Review [0.03%]
xenobiotic代谢酶多态性与卵巢癌关系的综述及机制探索
Harshavardhani Canchi Sistla,Srikanth Talluri,Sivaramakrishnan Venkatabalasubramanian et al.
Harshavardhani Canchi Sistla et al.
Ovarian cancer (OC), the third most common and fatal gynecological malignancy, is a heterogeneous disease characterized by genomic instability. The interaction between genetic and environmental factors, including xenobiotics, plays a crucia...
Tissue and Sex-Specific Performance of a Cancer Driver Based Biomarker in rasH2-Tg Mice [0.03%]
基于rasH2转基因小鼠的癌症驱动基因型生物标志物的组织和性别特异性表现
Kelly L Harris,Jennifer B Faske,Binsheng Gong et al.
Kelly L Harris et al.
The ability to predict rodent lifetime tumor responses from short-term exposures and a scientific basis for rodent to human extrapolation are unmet needs in cancer risk assessment. To address these needs, quantitation of cancer driver mutat...
E Demuynck,T Vanhaecke,A Thienpont et al.
E Demuynck et al.
Current genotoxicity testing strategies face several challenges, including a high incidence of misleading positive results that lead to unnecessary animal testing, limited mechanistic insights, insufficient integration of innovative methodo...
Analysis of Multiplexed Flow Cytometric Assays and Toxicogenomic Signatures for Genotoxicity Prediction: A Model Performance and Case Study Approach [0.03%]
用于遗传毒性预测的多重流式细胞仪分析和毒基因组特征的模型性能及案例研究方法学评估
Tomás Lagunas Jr,Fjodor Melnikov,Gabby Cole et al.
Tomás Lagunas Jr et al.
Genotoxicity assays play a significant role in protecting clinical trial subjects from potential increased risk of genotoxic hazard and cancer during drug development. Traditional genetic toxicology assays typically provide binary outcomes ...