Conserved Active Site Loop Residues of E. coli DinB and Human DNA Polymerase Kappa Govern Activity [0.03%]
大肠杆菌DinB和人类核糖核酸聚合酶κ保守的活性位点环状残基可控制其活性
Nicole M Antczak,Paul Ippoliti,Jiyoun Ahn et al.
Nicole M Antczak et al.
DNA damage is ubiquitous and can arise from numerous sources. To mitigate the potential effects of DNA damage, cells possess varied DNA repair and damage tolerance mechanisms. Conserved throughout evolution, specialized DNA damage-bypass DN...
Investigation of Ethylene Oxide Genotoxicity Dose-Response to Inform Cancer Risk Assessment [0.03%]
乙烯氧化物致基因毒性的剂量效应关系研究及其在癌症风险评估中的应用
B Bhaskar Gollapudi,James E Bus,Phillip Cassidy et al.
B Bhaskar Gollapudi et al.
Ethylene oxide (EtO) is primarily used as an intermediate in the manufacture of chemicals, with a minor use as a sterilant for medical equipment and food products. It is a direct-acting alkylating agent that reacts with cellular macromolecu...
Evaluating the Suitability of HepaRG Cells for Regulatory Micronucleus Testing: Comparing Results for a Diverse Set of 28 Chemicals to Regulatory Accepted TK6 Cells [0.03%]
HEPARG细胞进行监管 micronucleus检测的适用性评估：与官方认可的TK6细胞体系的一组多样化的28种化学物质的结果进行比较
Ashley Allemang,Stefan Pfuhler
Ashley Allemang
There is growing interest in in vitro-based new approach methodologies (NAMs) for assessing genotoxicity. These approaches are desirable for industries like cosmetics which are prohibited from animal testing due to regulatory restrictions, ...
Comparative Study
Environmental and molecular mutagenesis. 2026 Jun;67(5-7):e70062. DOI:10.1002/em.70062 2026
Resveratrol Mitigates Haloacetaldehyde Disinfection By-Products (HAL-DBPs)-Induced Oocyte Developmental Toxicity via Mitochondria-Dependent Pathways [0.03%]
白藜芦醇通过线粒体依赖途径缓解卤代丙醛消毒副产物（HAL-DBPs）诱导的卵细胞发育毒性
Zaishan Yang,Sien Yao,Qimei Xu et al.
Zaishan Yang et al.
Haloacetaldehyde disinfection by-products (HAL-DBPs), a class of unregulated emerging contaminants formed during drinking water chlorination, are widely detected in the aquatic environment, yet their potential reproductive toxicity remains ...
Sarita Garg,Isabelle R Miousse
Sarita Garg
While commonly described as an inhibitor of the histone methyltransferase EZH2, the compound 3-deazaneplanocin A (DZNep) functions as an inhibitor of S-adenosylhomocysteine hydrolase (SAHH), leading to pan-methyltransferase inhibition affec...
Transcriptional Dysregulation of Histone Methyltransferase Genes and Chromosomal Instability Associated With Chronic Pesticide Exposure [0.03%]
慢性农药暴露与组蛋白甲基转移酶基因转录失调和染色体不稳定有关
Renato Arthur Franco Rodrigues,Eduardo Vignoto Fernandes,Mayara Bocchi et al.
Renato Arthur Franco Rodrigues et al.
Occupational pesticide exposure is a significant environmental health concern associated with genomic instability. Histone methyltransferases including SMYD2, SMYD3, EZH2, and SETD8 participate in chromatin regulation and DNA damage respons...
Evaluation of Type 1 Error Rates in Duplex Sequencing for Mutagenicity Testing Using Vehicle Control Data and Simulation Analyses [0.03%]
基于载体对照数据和模拟分析评估双plex测序用于致突变检测的Ⅰ类错误率
Andrew Williams,Shaofei Zhang,Dingzhou Li et al.
Andrew Williams et al.
Accurate mutation detection and quantification are crucial for understanding mutagenesis and its potential health implications. Traditional in vivo mutagenicity assays, such as the transgenic rodent gene mutation assay, are limited by their...
Benzo[b]fluoranthene Induces Mutation Accumulation and Cancer-Relevant Mutational Signatures in Mouse Lung Alongside Steady State Levels of Chromosome Damage in Blood [0.03%]
苯并[a]荧蒽在小鼠肺中诱导突变积累及与癌症相关的突变特征，同时使小鼠血液中的染色体损伤保持稳态水平
Xinwen Zhang,Cheryl A Hobbs,Miriam V Rivas et al.
Xinwen Zhang et al.
Polycyclic aromatic hydrocarbons (PAHs) are well-known for their mutagenic and carcinogenic effects. Benzo[b]fluoranthene (BbF) is one of 16 PAHs prioritized by the US Environmental Protection Agency for toxicological evaluation due to perv...
Multi-Omics Integration Into Adverse Outcome Pathway Framework: Principles, Progress, and Prospects for Next-Generation Toxicological Risk Assessment [0.03%]
整合多组学的不良结果途径框架：原理、进展和下一代毒性风险评估前景
Rajesh Pamanji,Ragothaman Prathiviraj,Gisha Sivan
Rajesh Pamanji
The adverse outcome pathway (AOP) framework has emerged as an important tool in mechanistic toxicology, providing chemically agnostic representations of the causal biological sequence from molecular initiating events (MIEs) to apical advers...
Histopathological and Epigenetic Insights Into Radioprotective Effects of Homeopathic Cadmium Sulfuratum in Swiss Albino Mice [0.03%]
家.pathological和表观遗传学视角下微量镉硫在瑞士白鼠体内的放疗保护作用机制研究
Bekir Eren Çetin,Seda Ekici,Yasin Ozkabadayi et al.
Bekir Eren Çetin et al.
Epigenetic mechanisms regulating DNA gene expression have gained significant attention in recent years. MicroRNAs (miRNAs) play a key role in these mechanisms by modulating gene activity and relaying information throughout the body. This st...