Meta-Analysis of CYP1A1 MspI and Ile462Val Polymorphisms in Cancer Susceptibility Among Different Ethnic Populations [0.03%]
不同人种癌症易感性CYP1A1MspI和Ile462Val多态性的荟萃分析研究进展
Amjad Yousuf,Najeeb Ullah Khan,Ahsanullah Unar
Amjad Yousuf
The Cytochrome P450 1A1 (CYP1A1) gene plays a crucial role in the production of enzymes involved in the metabolic activation and detoxification of harmful carcinogens, which are essential for genetic susceptibility to cancer. Due to the inc...
Leslie Recio,Carol Swartz,Lincoln Martin et al.
Leslie Recio et al.
This interlaboratory evaluation of HepaRG CometChip was conducted to assess transferability and reproducibility of this new approach methodology (NAM) across four laboratories. Concentrations inducing up to ~70% relative cytotoxicity were d...
Investigation of Groove Damage Distribution in Proton-Induced Clustered B-DNA Damage [0.03%]
质子诱导的B-DNA簇损伤沟痕分布的研究
Shanshan Bao,Guang Hu,Chao Wang et al.
Shanshan Bao et al.
Accurate measurement of DNA damage is critical for therapeutic optimization in proton-based targeted radiotherapy. This research pioneered the first investigation into the groove damage distribution mechanism in clustered B-DNA damage induc...
Identification of Most Stably Expressed Internal Control Genes for Normalization of Target Gene Expression in Buffalo Skin Tissue [0.03%]
buffalo皮肤组织中最稳定的内参基因筛选及验证
Ankita Gurao,Anurag Kumar,Namita Kumari et al.
Ankita Gurao et al.
Water buffalo (Bubalus bubalis) skin exhibits unique morphological and physiological adaptations compared to other domestic bovines to enhance thermoregulation facilitated by abundant dermal melanin. Melanin synthesis and distribution, gove...
The In Vitro Transgenic Rodent Assay in Primary MutaMouse Hepatocytes Compared to the Mammalian Cell Gene Mutation Assay Using the HPRT Gene [0.03%]
主要MutaMouse肝细胞的体内类鼠转基因实验与运用HPRT基因的哺乳动物细胞基因突变试验的比较研究
Alina Göpfert,Kylee Kendra Marie Ronnenberg,Claudia Ruelker et al.
Alina Göpfert et al.
Gene mutations can be detected in mammalian cells in vitro using indicator genes such as the hypoxanthine-guanine-phosphoribosyltransferase (HPRT) gene. These assays have been adopted as OECD test guidelines (TG, e.g., OECD TG no. 476) and ...
Identifying Gene Predictors of Chemicals Linked With Breast Cancer: A Machine Learning Analysis of MCF7 Cellular Transcriptomic Screening Data [0.03%]
基于MCF7细胞转录组筛选数据的乳腺癌相关化学物质基因预测因子识别分析研究机器学习
Lauren E Koval,Richard Judson,Julia E Rager
Lauren E Koval
Breast cancer is the most prevalent cancer in women and has been linked to exposure to environmental chemicals. However, many chemicals have not been evaluated for relationships with this outcome. In this study, we analyzed RNA sequencing d...
Vinita Chauhan,Veronica S Grybas,Devyn Hoopfer et al.
Vinita Chauhan et al.
Long-duration spaceflight exposes astronauts to various stressors that can alter human physiology, potentially causing immediate and long-term health effects. These stressors can damage biomolecules, cells, tissues, and organs, leading to a...
Mariane A P Silva,Mónica Cappetta,Tony F Grassi et al.
Mariane A P Silva et al.
Millions of healthcare professionals are occupationally exposed to waste anesthetic gases (WAGs) worldwide; however, their effect on DNA methylation is unknown. Thus, for the first time, global DNA methylation analysis was performed in addi...
David M DeMarini
David M DeMarini
The 10 Key Characteristics of Carcinogens (KCs) were developed by the International Agency for Research on Cancer (IARC) as a framework for organizing mechanistic data for evaluating agents as potential human carcinogens. They emerged from ...