Multi-Omics Integration Into Adverse Outcome Pathway Framework: Principles, Progress, and Prospects for Next-Generation Toxicological Risk Assessment [0.03%]
整合多组学的不良结果途径框架：原理、进展和下一代毒性风险评估前景
Rajesh Pamanji,Ragothaman Prathiviraj,Gisha Sivan
Rajesh Pamanji
The adverse outcome pathway (AOP) framework has emerged as an important tool in mechanistic toxicology, providing chemically agnostic representations of the causal biological sequence from molecular initiating events (MIEs) to apical advers...
Histopathological and Epigenetic Insights Into Radioprotective Effects of Homeopathic Cadmium Sulfuratum in Swiss Albino Mice [0.03%]
家.pathological和表观遗传学视角下微量镉硫在瑞士白鼠体内的放疗保护作用机制研究
Bekir Eren Çetin,Seda Ekici,Yasin Ozkabadayi et al.
Bekir Eren Çetin et al.
Epigenetic mechanisms regulating DNA gene expression have gained significant attention in recent years. MicroRNAs (miRNAs) play a key role in these mechanisms by modulating gene activity and relaying information throughout the body. This st...
Urinary Biomarkers of Exposure and Effect in California Schoolchildren From a High Air Pollution Area [0.03%]
加州重污染地区学龄儿童暴露和效应的尿生物标志物研究
Weihong Guo,Rosemary Castorina,Susan Hurley et al.
Weihong Guo et al.
Exposure to air pollution is associated with adverse health effects such as asthma, lung cancer, and cardiovascular diseases. Children are especially vulnerable due to their developing organs, immature immune systems, and higher ventilation...
Computational Analysis of Differentially Expressed Genes in Arsenic-Induced Carcinogenesis and Their Effect on Human Repair Mechanisms [0.03%]
砷致致癌的差异表达基因的计算分析及其对人体修复机制的影响
Lucky Parida,Trupti N Patel
Lucky Parida
Arsenic poisoning significantly elevates the risk of cancer and other chronic illnesses. The goal of this research is to identify important genes whose expression changes in response to arsenic toxicity, and the molecular pathways affected ...
Copper Pyrithione Inhibits Trophoblast Cell Function: Mechanisms Underlying Its Embryotoxic Potential [0.03%]
铜取代硫化物抑制滋养细胞功能：其致胚胎毒性的机制研究
Ziqin Lu,Xiangxue Cai,Xiumei Wang et al.
Ziqin Lu et al.
Copper pyrithione (CuPT), a widely used antimicrobial agent in antifouling coatings and consumer products, has potential reproductive toxicity. This study aims to evaluate the impact of CuPT on human trophoblast-like JEG-3 cells and elucida...
Brief Communication: Increased Frequency of Micronucleus in the Bone Marrow of Mice Under Simulated Occupational Exposure to Isoflurane [0.03%]
简短通讯：职业暴露于异氟醚可增加小鼠骨髓微核频率
Marina Zanin,Mariana Gobbo Braz,Maria Vitória Destro et al.
Marina Zanin et al.
Isoflurane is a widely used inhalational anesthetic. Occupational exposure to waste anesthetic gases (WAGs) raises concerns about DNA damage. Bone marrow, highly susceptible due to its proliferative activity, has been scarcely investigated ...
Analysis of Mutagenesis in the Escherichia coli tdk Gene: The Nucleoid Protein HNS Is Required for a Dramatic Cisplatin-Induced Hotspot [0.03%]
大肠杆菌tdk基因诱变分析：染色体结构蛋白HNS是顺铂诱导热点的必要条件
Dana Sorensen,Tara Mata,Ananya Sridharan et al.
Dana Sorensen et al.
We demonstrate the utility of the tdk reporter gene system, by showing its ability to not only analyze mutational hotspots, but also to allow the analysis of both weak and strong mutator or mutagen effects. It can detect large and small ins...
Oxidative DNA Damage Exacerbates the Mutagenic Potential of Alternative DNA Structures via Altered DNA Repair Processing [0.03%]
氧化性DNA损伤通过改变DNA修复过程来增强替代DNA结构的诱变潜力
Alex W Klattenhoff,Maha Zewail-Foote,Arti Madan et al.
Alex W Klattenhoff et al.
Alternative DNA structure-forming (i.e., non-B) sequences such as H-DNA-forming sequences are enriched at chromosomal translocation hotspots in human cancer genomes, underscoring their role in genomic instability. H-DNA is particularly susc...
Benchmark Response Values for Error-Corrected Sequencing Mutagenicity Assessment Technologies [0.03%]
错配修复缺陷的富集和基准响应值在误差校正测序诱变评估技术中的作用
Saron Mulugeta,Francesco Marchetti,Guangchao Chen et al.
Saron Mulugeta et al.
The Benchmark Dose (BMD) approach is commonly used to determine Point-of-Departure (PoD) values for risk assessment and regulatory decision-making; however, choosing a suitable Benchmark Response (BMR) for continuous endpoints is a challeng...
Longitudinal Assessment of DNA Damage in PBMCs From Hospitalized COVID-19 Patients via Alkaline Comet Assay [0.03%]
碱性彗星测定法评估住院COVID-19患者的外周血单个核细胞中的DNA损伤
Lenin Rueda-Torres,Dulce E Alarcón-Yaquetto,Beatriz Ayala-Quintanilla et al.
Lenin Rueda-Torres et al.
Growing evidence suggests an association between SARS-CoV-2 infection and oxidative stress-related genomic damage, primarily from cross-sectional studies. However, longitudinal evaluations remain limited. Here, we assessed DNA damage in per...