Genotoxicity evaluation of gene therapies: A report from the International Workshop on Genotoxicity Testing (IWGT) 2022 [0.03%]
国际基因毒性测试工作坊(IWGT) 2022关于基因治疗的遗传毒性评估报告
S Libertini,J K Jadlowsky,T A Lanz et al.
S Libertini et al.
At the 8th International Workshop on Genotoxicity Testing meeting in Ottawa, in August 2022, a plenary session was dedicated to the genotoxicity risk evaluation of gene therapies, including insertional oncogenesis and off-target genome edit...
Power analyses to inform Duplex Sequencing study designs for MutaMouse liver and bone marrow [0.03%]
用于MutaMouse肝脏和骨髓Duplex测序研究设计的效能分析
Elena Esina,Annette E Dodge,Andrew Williams et al.
Elena Esina et al.
Regulatory genetic toxicology testing is essential for identifying potentially mutagenic hazards. Duplex Sequencing (DS) is an error-corrected next-generation sequencing technology that provides substantial advantages for mutation analysis ...
High frequency of silent mutations in gyrA gene of Mycobacterium tuberculosis in Indian isolates [0.03%]
印度分离株中结核分枝杆菌gyrA基因的沉默突变高频出现
Anamika Gupta,Sudhir K Pal,Vijay Nema
Anamika Gupta
Reporting any uncommon or untapped changes in bacterial genetics or physiology would be of great importance to support the drug development process. We studied 120 Mycobacterium tuberculosis clinical isolates with different geographical ori...
Mutagenicity of the agriculture pesticide chlorothalonil assessed by somatic mutation and recombination test in Drosophila melanogaster [0.03%]
果蝇体细胞突变和重组试验评估农药氯thalonil的致突变性
Bruno Veber,Mariana do Amaral Flores,Mauricio Lehmann et al.
Bruno Veber et al.
Chlorothalonil (CTL) is a pesticide widely used in Brazil, yet its mutagenic potential is not fully determined. Thus, we assessed the mutagenicity of CTL and its bioactivation metabolites using the somatic mutation and recombination test (S...
Epigenotoxicity: Decoding the epigenetic imprints of genotoxic agents and their implications for regulatory genetic toxicology [0.03%]
致突变物质的表观遗传印记及其对监管遗传毒理学意义的解读
Roger Godschalk,Christopher Faulk,Jessica LaRocca et al.
Roger Godschalk et al.
Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy ...
Assessment of genotoxic potential of fragrance materials in the chicken egg assays [0.03%]
鸡胚试验中香料物质的致基因毒性评估
Yax Thakkar,Tetyana Kobets,Anne Marie Api et al.
Yax Thakkar et al.
The genotoxic and clastogenic/aneugeneic potentials of four α,β-unsaturated aldehydes, 2-phenyl-2-butenal, nona-2-trans-6-cis-dienal, 2-methyl-2-pentenal, and p-methoxy cinnamaldehyde, which are used as fragrance materials, were assessed ...
AOP report: Development of an adverse outcome pathway for deposition of energy leading to learning and memory impairment [0.03%]
AOP报告：能量沉积导致学习和记忆损伤的不良结局路径构建
Ahmad Sleiman,Kathleen B Miller,Danicia Flores et al.
Ahmad Sleiman et al.
Understanding radiation-induced non-cancer effects on the central nervous system (CNS) is essential for the risk assessment of medical (e.g., radiotherapy) and occupational (e.g., nuclear workers and astronauts) exposures. Herein, the adver...
Rasha Q Al-Rahahleh,Robert W Sobol
Rasha Q Al-Rahahleh
ADP-ribosylation is a reversible post-translational modification that plays a role as a signaling mechanism in various cellular processes. This modification is characterized by its structural diversity, highly dynamic nature, and short half...
Evaluation of the nitrosamine impurities of ACE inhibitors using computational, in vitro, and in vivo methods demonstrate no genotoxic potential [0.03%]
评估ACE抑制剂中的亚硝胺杂质的计算、体外和体内方法证明无致基因突变潜力
Jennifer Cheung,Krista Dobo,Shaofei Zhang et al.
Jennifer Cheung et al.
Evaluation and mitigation of the potential carcinogenic risks associated with nitrosamines in marketed pharmaceutical products are areas of interest for pharmaceutical companies and health authorities alike. Significant progress has been ma...
Assessing the genotoxicity of N-nitrosodiethylamine with three in vivo endpoints in male Big Blue® transgenic and wild-type C57BL/6N mice [0.03%]
评估N-亚硝基二乙胺在雄性Big Blue转基因小鼠和野生型C57BL/6N小鼠中的三个体内终点的遗传毒性
Shaofei Zhang,Stephanie L Coffing,William C Gunther et al.
Shaofei Zhang et al.
The detection of N-nitrosamines in drug products has raised global regulatory interest in recent years due to the carcinogenic potential of some nitrosamines in animals and a need to identify a testing strategy has emerged. Ideally, methods...