Evaluation of the standard battery of in vitro genotoxicity tests to predict in vivo genotoxicity through mathematical modeling: A report from the 8th International Workshop on Genotoxicity Testing [0.03%]
基于数学建模评估体外遗传毒性试验标准方案预测体内遗传毒性的能力：第8届国际遗传毒性测试研讨会报告摘要
Mirjam Luijten,Jan van Benthem,Takeshi Morita et al.
Mirjam Luijten et al.
In human health risk assessment of chemicals and pharmaceuticals, identification of genotoxicity hazard usually starts with a standard battery of in vitro genotoxicity tests, which is needed to cover all genotoxicity endpoints. The individu...
Rosalie K Elespuru
Rosalie K Elespuru
This work describes career "adventures" into applied research in environmental mutagenesis. Surprising and interesting results, as well as publications in Nature and Science, may counter an assumption that applied research is not as excitin...
Transcriptomic and epigenomic signatures distinguish high- and low-risk endotypes for liver tumor development [0.03%]
转录组和表观基因组特征可区分肝肿瘤发生的风险不同的亚型
Sandra L Grimm,Tia Talley,Rahul K Jangid et al.
Sandra L Grimm et al.
The epigenome is a target for environmental exposures and a potential determinant of inter-individual differences in response. In genetically identical C57Bl/6 mice exposed from gestation to weaning to the endocrine-disrupting chemical (EDC...
Investigation of mutagenicity of styrene in tumor target and non-target tissues of transgenic Big Blue® mice [0.03%]
应用转基因Big Blue小鼠研究苯乙烯的致突变性及非目标组织中的诱突变作用
B Bhaskar Gollapudi,Karen Philp,Jeffrey T Weinberg
B Bhaskar Gollapudi
Styrene has been shown to induce lung tumors in mice, but not in rats. The current study investigated the potential role of genotoxicity as an initial key event in the mode of action for styrene-induced lung tumors in mice. Transgenic male ...
AOP report: Development of an adverse outcome pathway for deposition of energy leading to abnormal vascular remodeling [0.03%]
AOP报告：能量沉积导致异常血管重塑的不良结局途径构建
Tatiana Kozbenko,Nadine Adam,Veronica S Grybas et al.
Tatiana Kozbenko et al.
Cardiovascular diseases (CVDs) are complex, encompassing many types of heart pathophysiologies and associated etiologies. Radiotherapy studies have shown that fractionated radiation exposure at high doses (3-17 Gy) to the heart increases th...
Absence of genotoxicity following pulmonary exposure to metal oxides of copper, tin, aluminum, zinc, and titanium in mice [0.03%]
铜、锡、铝、锌和钛氧化物肺暴露的无遗传毒性
Claudia Torero Gutierrez,Niels Hadrup,Charis Loizides et al.
Claudia Torero Gutierrez et al.
Inhalation of nanosized metal oxides may occur at the workplace. Thus, information on potential hazardous effects is needed for risk assessment. We report an investigation of the genotoxic potential of different metal oxide nanomaterials. A...
Anatomy of a hotspot: Cisplatin hotspots in the tdk gene of Escherichia coli [0.03%]
热点剖析：大肠杆菌中顺铂敏感的tdk基因热区分析
Courtney Young,Mackenzie Lee,Zoe Ge et al.
Courtney Young et al.
We previously reported that certain sub-regions of the thyA gene of Escherichia coli are more mutable than others when many different mutagens and mutators are analyzed (Mashiach et al., Mutation Research Fundamental Molecular Mechansims of...
AOP Report: Development of an adverse outcome pathway for deposition of energy leading to bone loss [0.03%]
AOP报告：能量沉积导致骨丢失的不良结果通路的发展
Snehpal Sandhu,Mitchell Keyworth,Syna Karimi-Jashni et al.
Snehpal Sandhu et al.
Bone loss, commonly seen in osteoporosis, is a condition that entails a progressive decline of bone mineral density and microarchitecture, often seen in post-menopausal women. Bone loss has also been widely reported in astronauts exposed to...
Artificial targeting of the NEIL1 DNA glycosylase to the mitochondria [0.03%]
NEIL1 DNA糖基化酶的人工靶向定位至线粒体
Marlo K Thompson,Mark H Eggers,Ryan G Benton et al.
Marlo K Thompson et al.
The human NEIL1 DNA glycosylase is one of 11 mammalian glycosylases that initiate base excision repair. While substrate preference, catalytic mechanism, and structural information of NEIL1's ordered residues are available, limited informati...