Review of Transcriptomic Biomarkers That Predict In Vitro Genotoxicity in Human Cell Lines [0.03%]
综述转录组生物标志物预测人体细胞系的体外遗传毒性
Heng-Hong Li,Jiri Aubrecht,Tatyana Y Doktorova et al.
Heng-Hong Li et al.
The current genotoxicity testing paradigm provides little mechanistic information, has poor specificity in predicting carcinogenicity in humans, and is not suited to assessing a large number of chemicals. Genomic technologies enable the cha...
Gopala Krishna
Gopala Krishna
Characterizing the Pulmonary Toxicity and Potential Mutagenicity of Formaldehyde Fumes in a Human Bronchial Epithelial Tissue Model [0.03%]
甲醛烟雾对人体支气管上皮组织模型的肺毒性及潜在诱变性的特征分析
Yuan Le,Baiping Ren,Levan Muskhelishvili et al.
Yuan Le et al.
Formaldehyde (FA) is a highly reactive aldehyde that is regarded as an inhalation hazard and human carcinogen. Herein, we report a follow-up study evaluating the effects of exposure duration on the toxicity and mutagenicity of FA using a hu...
Epigenetic Modifications Associated With Wildland-Urban Interface (WUI) Firefighting [0.03%]
与野生城市接合部(WUI)消防相关的表观遗传修饰
Jaclyn M Goodrich,Melissa A Furlong,Derek J Urwin et al.
Jaclyn M Goodrich et al.
Wildland-urban interface (WUI) firefighting involves exposure to burning vegetation, structures, and other human-made hazards, often without respiratory protection. Response activities can last for long periods of time, spanning multiple da...
Review and meta-analysis of gene expression biomarkers predictive of chemical-induced genotoxicity in vivo [0.03%]
基因表达生物标志物预测化学诱导的体内遗传毒性的回顾和元分析
J Christopher Corton,Scott S Auerbach,Naoki Koyama et al.
J Christopher Corton et al.
There is growing recognition across broad sectors of the toxicology community that gene expression biomarkers have the potential to identify genotoxic and nongenotoxic carcinogens through a weight-of-evidence approach, providing opportuniti...
Assessing the impact of different solvents in the bacterial reverse mutation test [0.03%]
评估不同溶剂在细菌回复突变试验中所产生的影响
Satyam N Patel,Chetan K Kajavadara,Rushikesh M Shukla et al.
Satyam N Patel et al.
The bacterial reverse mutation test is essential for identifying the mutagenic potential of chemicals. The solubility of the test substance is vital for achieving the recommended assay concentration. Preferred solvents like dimethyl sulfoxi...
Consensus findings of an International Workshops on Genotoxicity Testing workshop on using transcriptomic biomarkers to predict genotoxicity [0.03%]
遗传毒性预测的转录生物标志物使用的国际研讨会共识意见
Roland Froetschl,J Christopher Corton,Henghong Li et al.
Roland Froetschl et al.
Gene expression biomarkers have the potential to identify genotoxic and non-genotoxic carcinogens, providing opportunities for integrated testing and reducing animal use. In August 2022, an International Workshops on Genotoxicity Testing (I...
Machine learning enhances genotoxicity assessment using MultiFlow® DNA damage assay [0.03%]
机器学习增强MultiFlow®DNA损伤测定的遗传毒性评估能力
Panuwat Trairatphisan,Lena Dorsheimer,Peter Monecke et al.
Panuwat Trairatphisan et al.
Genotoxicity is a critical determinant for assessing the safety of pharmaceutical drugs, their metabolites, and impurities. Among genotoxicity tests, mechanistic assays such as the MultiFlow® DNA damage assay (MFA) allows the investigation...
Genetic instability of a single exposure to sevoflurane at different concentrations in monitored mice [0.03%]
不同浓度的七氟醚单次暴露致小鼠遗传不稳定性的研究
Maria Vitória Destro,Mariane A P Silva,Tony F Grassi et al.
Maria Vitória Destro et al.
Sevoflurane is an inhalation anesthetic widely used for general anesthesia, but its genotoxic potential is controversial in clinical studies. It is unknown whether the effects are due to surgery or the anesthetic. Thus, for the first time, ...
Outcome of IWGT workshop on transcriptomic biomarkers for genotoxicity: Key considerations for bioinformatics [0.03%]
IWGT转录组生物标志物基因毒性工作组研讨会成果：生物信息学关键考虑因素
Matthew J Meier,Florian Caiment,J Christopher Corton et al.
Matthew J Meier et al.
As a part of the International Workshop on Genotoxicity Testing (IWGT) in 2022, a workgroup was formed to evaluate the level of validation and regulatory acceptance of transcriptomic biomarkers that identify genotoxic substances. Several su...