Polymorphisms in CLAUDIN1 and SPINK5 Influence Skin Absorption of Pyrene, Pyrimethanil, and Oxybenzone in Human Volunteers [0.03%]
CLAUDIN1和SPINK5多态性影响人类志愿者皮肤吸收氯苯并[a]芘、嘧菌酯和氧苯酮的作用
Emmy Keysendal,Gunnar Johanson,Lina Hagvall et al.
Emmy Keysendal et al.
Absorption of chemicals through the skin affects occupational and environmental exposure to diverse compounds. We previously showed that loss-of-function (null) mutations and low-copy number variants (CNV) of Filaggrin (FLG), which encodes ...
Vitamin C Regulates Redox Homeostasis and Mitigates Potassium Bromate-Induced Oxidative Injury to Rat Intestine [0.03%]
维生素C调节氧化还原稳态并减轻溴酸钾所致大鼠肠道氧化损伤
Saima Nazir,Mir Kaisar Ahmad,Zubair-Ul-Nazir
Saima Nazir
Potassium bromate (KBrO3), a probable human carcinogen, is generated as a disinfection by-product during ozonation of water and is also used as a flour maturing agent. It has been shown to induce oxidative damage and subsequent tissue-toxic...
Alizarin Dye: Toxicity, Genotoxicity, and Histopathological Alterations in Model Organisms [0.03%]
阿郎尼斯染料：对模式生物的毒性、遗传毒性和组织病理变化
Amanda Rocha Rodrigues,Gabriela Cristina Fonseca Almeida,Natália Oliveira de Farias et al.
Amanda Rocha Rodrigues et al.
Alizarin is an anthraquinone red dye from natural or synthetic sources, widely used in textiles. Effluents of this activity can contain residual dyes, which may contaminate the aquatic environment. Studies report alizarin's aquatic toxicity...
A Survey of DNA Damage in American Alligators (Alligator mississippiensis) in Florida [0.03%]
美国佛罗里达州短吻鳄(DNA损伤调查报告)
Haiyan Lu,Idoia Meaza,Rachel M Wise et al.
Haiyan Lu et al.
The scientific concept of One Environmental Health is a research strategy focused on the study of toxicants, aiming to incorporate human, wildlife, and ecosystem health to establish a more comprehensive understanding of health. A One Enviro...
Adjusting the Preincubation Conditions to Enhance the Ames Test for Detecting the Mutagenicity of N-Nitrosamines [0.03%]
通过调整预孵育条件增强Ames试验检测N-亚硝胺致突变性的能力
Michelle E Bishop,Audrey M Sims,Sharon K Guerrero et al.
Michelle E Bishop et al.
Conducting S9-mediated preincubations at slightly acid pHs (e.g., pH 5.0 to pH 6.5) has been reported to enhance the mutagenicity of small-molecule nitrosamines in the Ames test. In this study, we have evaluated the effect of adjusting the ...
Summary of Major Conclusions From the 8th International Workshop on Genotoxicity Testing (IWGT), Ottawa, Canada [0.03%]
第八届国际致突变试验研讨会(渥太华，加拿大)主要结论摘要
Hans-Joerg Martus,Carol Beevers,Stephen Dertinger et al.
Hans-Joerg Martus et al.
Meta-Analysis of CYP1A1 MspI and Ile462Val Polymorphisms in Cancer Susceptibility Among Different Ethnic Populations [0.03%]
不同人种癌症易感性CYP1A1MspI和Ile462Val多态性的荟萃分析研究进展
Amjad Yousuf,Najeeb Ullah Khan,Ahsanullah Unar
Amjad Yousuf
The Cytochrome P450 1A1 (CYP1A1) gene plays a crucial role in the production of enzymes involved in the metabolic activation and detoxification of harmful carcinogens, which are essential for genetic susceptibility to cancer. Due to the inc...
Leslie Recio,Carol Swartz,Lincoln Martin et al.
Leslie Recio et al.
This interlaboratory evaluation of HepaRG CometChip was conducted to assess transferability and reproducibility of this new approach methodology (NAM) across four laboratories. Concentrations inducing up to ~70% relative cytotoxicity were d...
Investigation of Groove Damage Distribution in Proton-Induced Clustered B-DNA Damage [0.03%]
质子诱导的B-DNA簇损伤沟痕分布的研究
Shanshan Bao,Guang Hu,Chao Wang et al.
Shanshan Bao et al.
Accurate measurement of DNA damage is critical for therapeutic optimization in proton-based targeted radiotherapy. This research pioneered the first investigation into the groove damage distribution mechanism in clustered B-DNA damage induc...
Identification of Most Stably Expressed Internal Control Genes for Normalization of Target Gene Expression in Buffalo Skin Tissue [0.03%]
buffalo皮肤组织中最稳定的内参基因筛选及验证
Ankita Gurao,Anurag Kumar,Namita Kumari et al.
Ankita Gurao et al.
Water buffalo (Bubalus bubalis) skin exhibits unique morphological and physiological adaptations compared to other domestic bovines to enhance thermoregulation facilitated by abundant dermal melanin. Melanin synthesis and distribution, gove...