Germ cell mutagens: risk assessment challenges in the 21st century [0.03%]
二十一世纪 germ cell 致突变物的危险评估面临的挑战
Timothy M Singer,Carole L Yauk
Timothy M Singer
Heritable mutations may result in a wide variety of detrimental outcomes, from embryonic lethality to genetic disease in the offspring. Despite this, today's commonly used test batteries do not include assays for germ cell mutation. Current...
Antigenotoxic effects of p53 on spontaneous and ultraviolet light B--induced deletions in the epidermis of gpt delta transgenic mice [0.03%]
p53的抗致突变作用及其对转基因GPT小鼠表皮自发和UVB诱导的缺失的影响
Kenichi Masumura,Yasuteru Sakamoto,Megumi Ikeda et al.
Kenichi Masumura et al.
Tumor development in the skin may be a multistep process where multiple genetic alterations occur successively. The p53 gene is involved in genome stability and thus is referred to as "the guardian of the genome." To better understand the a...
Erica M Hlavin,Michael B Smeaton,Paul S Miller
Erica M Hlavin
Interstrand cross-links (ICLs) are among the most cytotoxic DNA lesions to cells because they prevent the two DNA strands from separating, thereby precluding replication and transcription. Even though chemotherapeutic cross-linking agents a...
John M Hinz
John M Hinz
Homologous recombination repair (HRR) encompasses mechanisms that employ homologous DNA sequences as templates for repair or tolerance of a wide range of DNA lesions that inhibit DNA replication in S phase. Arguably the most imposing of the...
Multiple roles of ERCC1-XPF in mammalian interstrand crosslink repair [0.03%]
ERCC1-XPF在哺乳动物链间交联修复中的多种作用
Jennifer J Rahn,Gerald M Adair,Rodney S Nairn
Jennifer J Rahn
DNA interstrand crosslinks (ICLs) are among the most deleterious cytotoxic lesions encountered by cells, mainly due to the covalent linkage these lesions create between the two strands of DNA which effectively blocks replication and transcr...
Translesion DNA synthesis polymerases in DNA interstrand crosslink repair [0.03%]
DNA交联修复中的跨损伤DNA合成聚合酶
The Vinh Ho,Orlando D Schärer
The Vinh Ho
DNA interstrand crosslinks (ICLs) are induced by a number of bifunctional antitumor drugs such as cisplatin, mitomycin C, or the nitrogen mustards as well as endogenous agents formed by lipid peroxidation. The repair of ICLs requires the co...
Repair of DNA interstrand cross-links during S phase of the mammalian cell cycle [0.03%]
哺乳动物细胞周期S期DNA链间交联的修复
Randy J Legerski
Randy J Legerski
DNA interstrand cross-linking (ICL) agents are widely used in anticancer chemotherapy regimens, yet our understanding of the DNA repair mechanisms by which these lesions are removed from the genome remains incomplete. This is at least in pa...
Mammalian nucleotide excision repair proteins and interstrand crosslink repair [0.03%]
哺乳动物核苷酸切除修复蛋白及链间交联修复
Richard D Wood
Richard D Wood
Although various schemes for interstrand crosslink (ICL) repair incorporate DNA recombination, replication, and double-strand break intermediate steps, action of the nucleotide excision repair (NER) system or some variation of it is a commo...
Assessing the link between BACH1/FANCJ and MLH1 in DNA crosslink repair [0.03%]
评估BACH1/FANCJ与MLH1在DNA交联修复中的联系
Sharon B Cantor,Jenny Xie
Sharon B Cantor
FANCJ (also known as BRIP1 or BACH1) is a DNA helicase that was originally identified by its direct interaction with the hereditary breast cancer protein, BRCA1. Similar to BRCA1, FANCJ function is essential for DNA repair and breast cancer...
DNA interstrand crosslinks: repair, cell signaling, and therapeutic implications [0.03%]
DNA交联损伤的修复、信号转导和治疗意义
Karen M Vasquez,Randy J Legerski
Karen M Vasquez