Mouse models to explore the biological and organismic role of DNA polymerase beta [0.03%]
探讨DNA聚合酶β的生物学和有机作用的小鼠模型
Robert W Sobol
Robert W Sobol
Gene knock-out (KO) mouse models for DNA polymerase beta (Polβ) revealed that loss of Polβ leads to neonatal lethality, highlighting the critical organismic role for this DNA polymerase. While biochemical analysis and gene KO cell lines h...
Interlaboratory validation of the ToxTracker assay: An in vitro reporter assay for mechanistic genotoxicity assessment [0.03%]
ToxTracker体外报告基因检测的实验室间验证：一种机制遗传毒性评估方法
Giel Hendriks,Els Adriaens,Ashley Allemang et al.
Giel Hendriks et al.
ToxTracker is a mammalian cell reporter assay that predicts the genotoxic properties of compounds with high accuracy. By evaluating induction of various reporter genes that play a key role in relevant cellular pathways, it provides insight ...
Investigations on the genotoxic potential of styrene in Fischer 344 rats using multiple endpoints [0.03%]
采用多个指标研究苯乙烯对Fischer 344大鼠的遗传毒性效应
B Bhaskar Gollapudi
B Bhaskar Gollapudi
Genotoxicity of styrene monomer was evaluated in male Fischer 344 rats using the alkaline comet assay for DNA damage, micronucleus assay for cytogenetic damage and the Pig-a assay for gene mutations. In a dose range finding (DRF) study, sty...
Qualitative and quantitative changes in mitochondrial DNA associated with cervical cancer: A comprehensive review [0.03%]
宫颈癌相关的线粒体DNA定性和定量变化：综述性文章
Isadora Oliveira Ansaloni Pereira,Nayara Nascimento Toledo Silva,Angelica Alves Lima et al.
Isadora Oliveira Ansaloni Pereira et al.
Cervical cancer is the fourth most commonly diagnosed cancer in women and is considered a preventable disease, as vaccination and screening programs effectively reduce its incidence and mortality rates. Disease physiopathology and malignant...
Firefighting, per- and polyfluoroalkyl substances, and DNA methylation of genes associated with prostate cancer risk [0.03%]
消防员、含氟化合物与前列腺癌相关基因的DNA甲基化水平关系研究
Margaret Quaid,Jaclyn M Goodrich,Miriam M Calkins et al.
Margaret Quaid et al.
Prostate cancer is the leading incident cancer among men in the United States. Firefighters are diagnosed with this disease at a rate 1.21 times higher than the average population. This increased risk may result from occupational exposures ...
Jason Y Y Wong,Alexander H Fischer,Dalsu Baris et al.
Jason Y Y Wong et al.
The etiology of bladder cancer among never smokers without occupational or environmental exposure to established urothelial carcinogens remains unclear. Urinary mutagenicity is an integrative measure that reflects recent exposure to genotox...
Genotoxicity in humans exposed to arsenic, lithium, and boron in drinking water in the Bolivian Andes-A cross sectional study [0.03%]
在玻利维亚安第斯山脉饮水砷、锂和硼暴露人群的遗传毒性——一项横断面研究
Noemi Tirado,Josué Mamani,Jessica De Loma et al.
Noemi Tirado et al.
Elevated concentrations of arsenic, lithium and boron in drinking water have already been reported in Bolivia. Arsenic is known to cause genotoxicity but that caused by lithium and boron is less well known. The aim of the present cross-sect...
Ana Elizabeth González-Santiago,Alejandro Salvador Gómez-Cabrera,Raúl Cuauhtémoc Baptista-Rosas et al.
Ana Elizabeth González-Santiago et al.
Drug abuse is considered a global health problem with serious social impact. In recent decades, changes in drug consumption patterns have shown a clear rising trend in the use of multiple drugs. Although the buccal micronucleus cytome (BMCy...
Veterinarians exposed to inhaled anesthetic present chromosome damage, apoptosis and cell cycle changes [0.03%]
暴露于吸入麻醉后的兽医存在染色体损伤、细胞凋亡和细胞周期变化的问题
Mariana G Braz,Drielle B S Figueiredo,Marjorie A Golim et al.
Mariana G Braz et al.
This cross-sectional study evaluated, for the first time, DNA damage, viability, and cell death of lymphocytes and cell cycle phases of mononuclear and polymorphonuclear cells in veterinarians exposed to the volatile anesthetic isoflurane. ...
Comparative analysis of micronucleus induction and DNA damage biomarkers in TK6 and A375 cells using flow cytometry [0.03%]
使用流式细胞术比较分析TK6和A375细胞中微核诱导和DNA损伤生物标志物
Xiaowen Sun,Richard A Spellman,Maria Engel et al.
Xiaowen Sun et al.
Previously, we introduced an alternative adherent A375 cell line for clastogenicity and aneugenicity testing using a high content imaging platform. To further characterize the performance of A375 cells, we investigated the sensitivity and s...