The effect of UGT1A and UGT2B polymorphisms on colorectal cancer risk: haplotype associations and gene–environment interactions [0.03%]
UGT1A和UGT2B基因多态性对结直肠癌风险的影响：单倍体型关联及基因-环境交互作用
Andrea Y Angstadt,Terryl J Hartman,Samuel M Lesko et al.
Andrea Y Angstadt et al.
UDP-glucuronosyltransferases (UGTs) play an important role in the phase II metabolism of exogenous and endogenous compounds. As colorectal cancer (CRC) etiology is thought to involve the biotransformation of dietary factors, UGT polymorphis...
No major effect of the CDH1 c.2440-6C>G mutation on splicing detected in last exon-specific splicing minigene assay [0.03%]
在特定外显子的剪接最小基因测定中未检测到CDH1c.2440-6C>G突变对剪接有重大影响
Lucie Grodecká,Michal Kramárek,Pavla Lockerová et al.
Lucie Grodecká et al.
Simultaneous analysis of the gene expression profiles of cancer and stromal cells in endometrial cancer [0.03%]
子宫内膜癌癌基因和间质细胞基因表达谱的联合分析
Yoko Iguchi,Yoichi M Ito,Fumio Kataoka et al.
Yoko Iguchi et al.
To address the role of cancer-stroma interactions, we performed gene expression profiling of both cancer and stroma, using matching samples of endometrial cancer (EC), and analyzed the relationship between the gene expression pattern and pr...
Frida Appelqvist,Maria Yhr,Anna Erlandson et al.
Frida Appelqvist et al.
The DNA repair gene MGMT (O-6-methylguanine-DNA methyltransferase) is important for maintaining normal cell physiology and genomic stability. Alterations in MGMT play a critical role in the development of several types of cancer, including ...
Identification and functional characterization of imatinib-sensitive DTD1-PDGFRB and CCDC88C-PDGFRB fusion genes in eosinophilia-associated myeloid/lymphoid neoplasms [0.03%]
伊马替尼敏感的DTD1-PDGFRB和CCDC88C-PDGFRB融合基因在嗜酸性细胞增多相关的髓系/淋巴组织增生性疾病中的鉴定与功能表征
Darko Gosenca,Beate Kellert,Georgia Metzgeroth et al.
Darko Gosenca et al.
Eosinophilia-associated myeloid neoplasms with rearrangement of chromosome bands 5q31-33 are frequently associated with PDGFRB fusion genes, which are exquisitely sensitive to treatment with imatinib. In search for novel fusion partners of ...
Differentiating soft tissue leiomyosarcoma and undifferentiated pleomorphic sarcoma: A miRNA analysis [0.03%]
肉瘤和未分化多形性肉瘤的微小核糖核酸分析区分软组织平滑肌肉瘤与未分化多形性软组织
Mohamed Guled,Laura Pazzaglia,Ioana Borze et al.
Mohamed Guled et al.
The rare and highly aggressive adult soft tissue sarcomas leiomyosarcoma (LMS) and undifferentiated pleomorphic sarcoma (UPS) contain complex genomes characterized by a multitude of rearrangements, amplifications, and deletions. Differentia...
Tumor genetics and survival of thymic neuroendocrine neoplasms: a multi-institutional clinicopathologic study [0.03%]
肿瘤遗传学和胸腺神经内分泌神经病患者的生存率：多机构临床病理研究
Philipp Ströbel,Andreas Zettl,Konstantin Shilo et al.
Philipp Ströbel et al.
Thymic neuroendocrine tumors (TNET) are rare primary epithelial neoplasms of the thymus. This study aimed to determine clinically relevant parameters for their classification and for therapeutic decisions. We performed a comprehensive histo...
Multicenter Study
Genes, chromosomes & cancer. 2014 Sep;53(9):738-49. DOI:10.1002/gcc.22183 2014
Different exosome cargo from plasma/bronchoalveolar lavage in non-small-cell lung cancer [0.03%]
非小细胞肺癌患者外周血和支气管肺泡灌洗液中不同来源的外泌体及其携带蛋白组学差异分析
Marta Rodríguez,Javier Silva,Ana López-Alfonso et al.
Marta Rodríguez et al.
Tumor-derived exosomes mediate tumorigenesis by facilitating tumor growth, metastasis, development of drug resistance, and immunosuppression. However, little is known about the exosomes isolated from bronchoalveolar lavage (BAL) in patients...
Can genome array screening replace FISH as a front-line test in multiple myeloma? [0.03%]
基因芯片检测技术能否替代FISH而成为治疗多发性骨髓瘤的一线方案？
Temenushka Boneva,Diana Brazma,Katya Gancheva et al.
Temenushka Boneva et al.
Multiple myeloma (MM) is a malignant disorder characterized by neoplastic transformation of mature B cells in the bone marrow (BM), accompanied by complex genetic changes. The disease is heterogeneous at both the clinical and genomic levels...
Ploidy and clinical characteristics of childhood acute myeloid leukemia: A NOPHO-AML study [0.03%]
儿童急性髓系白血病的倍体和临床特征：NOPHO-AML研究
Julie Damgaard Sandahl,Eigil Kjeldsen,Jonas Abrahamsson et al.
Julie Damgaard Sandahl et al.
We report the first large series (n = 596) of pediatric acute myeloid leukemia (AML) focusing on modal numbers (MN) from the population-based NOPHO-AML trials. Abnormal karyotypes were present in 452 cases (76%) and numerical aberrations we...