NF1 Mutated Gastrointestinal Stromal Tumors With Coamplification of MDM2 and MYC [0.03%]
NF1突变的胃肠道间质瘤合并MDM2和MYC共扩增
Xinyang Chen,Yang Lu,Xin He et al.
Xinyang Chen et al.
We report a unique case of a 57-year-old man with a gastrointestinal stromal tumor (GIST) that developed a high-grade phenotype and additional genetic alterations in the subsequent recurrence. Histologically, the initial resected tumor show...
Novel Resistance Mechanisms to Second-Generation EGFR Tyrosine Kinase Inhibitor Afatinib and Associations With Genomic Features in NSCLC [0.03%]
第二代表皮生长因子受体酪氨酸激酶抑制剂阿法替尼产生耐药性的新机制及其与基因组特征之间的关系在非小细胞肺癌中的研究
Fengwu Lin,Miaoqing Zhao,Qiang Wu et al.
Fengwu Lin et al.
Background: Afatinib, an irreversible pan-ERBB family inhibitor, has demonstrated promising efficacy in non-small cell lung cancer (NSCLC) patients with uncommon EGFR activating mutations. However, besides the acquisition...
"Benign" Metastasizing Fibrous Histiocytoma Harboring PRKCD Gene Fusions With Malignant Clinical Course [0.03%]
具有恶性临床病程的携带PRKCD基因融合的“良性”转移性纤维组织细胞瘤
Charlotte I Wang,Anne B Giersch,Santiago Lozano Calderon et al.
Charlotte I Wang et al.
Dermatofibroma/fibrous histiocytoma is a common tumor of the dermis, composed of myofibroblasts, dendrocytes, and macrophages with characteristic entrapment of dermal collagen fibers at the periphery of the tumor. Various subtypes of dermat...
TRAF7-Mutated Myxoid and Spindle Cell Mesenchymal Tumor Occurring in a Pediatric Patient in the Post-Transplant Setting: Expanding the Spectrum of TRAF7-Mutated Tumors [0.03%]
TRAF7基因突变的黏液样和梭形细胞间叶肿瘤发生在移植后的儿童患者中的病例报道：扩展了TRAF7基因突变肿瘤的谱系
Stephanie Torres,Zachary High,Qian Wang et al.
Stephanie Torres et al.
TRAF7 mutations have been reported in many tumor types, including subsets of meningiomas, mesothelioma, intraneural perineuriomas, and rare cases of aggressive fibromyxoid spindle cell tumors in adults. We expand the spectrum of TRAF7-mutat...
Primary Sweat Gland Adenocarcinoma of the Skin With ATL2::PRKD3 Fusion: A Potential Cutaneous Analog of Cribriform Adenocarcinoma of the Salivary Glands? [0.03%]
具有ATL2::PRKD3融合的皮肤主要汗腺腺癌：可能是腮腺筛状腺癌的皮肤类器官吗？
Anaïs Brunet,Barouyr Baroudjian,Maxence Mancini et al.
Anaïs Brunet et al.
Many cutaneous adnexal tumors share molecular alterations with other homologous neoplasms occurring in salivary glands. Polymorphous adenocarcinoma (PAC) is a rare salivary gland tumor, usually associated with alterations in the PRKD gene f...
A 107 Gene Nanostring Assay Effectively Translates the Cancer Genome Atlas, and Tumour Microenvironment Gastric Cancer Molecular Classification to a Patient-Derived Organoid Model [0.03%]
一个由107个基因组成的Nanostring检测有效地将胃癌的肿瘤免疫微环境分子分型转化到患者来源的类器官模型中
D Skubleny,K Purich,T Williams et al.
D Skubleny et al.
There is a need to improve the translation of gastric cancer molecular classification schemes, such as those proposed by the Cancer Genome Atlas (TCGA) and Tumour Microenvironment score (TME), to clinical specimens and three-dimensional org...
Resurfacing Threats: Metastatic Ossifying Fibromyxoid Tumor Emerging After Almost Two Decades [0.03%]
久治复发的骨化性纤维黏液样肿瘤的影像学表现
Mario Ambros,Bernadette Liegl-Atzwanger,Karl Kashofer et al.
Mario Ambros et al.
Background: Ossifying fibromyxoid tumor (OFMT) is an extremely rare mesenchymal tumor of uncertain differentiation having a potential for local recurrences and metastasis. OFMT can be classified as typical, atypical, and ...
Novel SMARCA2::DDIT3 Fusion in Primary Subcutaneous Myxoid Liposarcoma due to an Unusual Unbalanced Chromosomal Translocation [0.03%]
由于不寻常的不平衡染色体易位引起的一次原发性皮下黏液样脂肪肉瘤中新型SMARCA2::DDIT3融合基因的形成
Ahmed Shah,William R Sukov,Kevin Halling et al.
Ahmed Shah et al.
Myxoid liposarcoma (MLS) accounts for 20%-30% of all liposarcomas, with most cases harboring the fusion gene FUS::DDIT3, while approximately 5% exhibit the EWSR1::DDIT3 fusion. We report the case of a 26-year-old male patient with a right u...
Durable Response to Pazopanib (Tyrosine Kinase Inhibitor) in a Patient With EWSR1::CREM Gene Fusion Positive Intra-Abdominal Unclassified Epithelioid Sarcoma [0.03%]
帕唑帕尼（酪氨酸激酶抑制剂）对EWSR1::CREM基因融合阳性腹腔内未分类上皮样肉瘤患者的持续反应
Saba Shafi,Dan Jones,Xiaokang Pan et al.
Saba Shafi et al.
EWSR1::CREM fusion positive intrabdominal sarcomas defines a rare emerging group of aggressive mesenchymal neoplasms with a predilection for the celomic cavity and often manifesting perplexing immunophenotypic profile. There is no specific ...
Molecular Landscape of Pediatric Low-Grade Gliomas: Insights From RNA-NGS and Bioinformatic Analysis [0.03%]
儿童低级别胶质瘤的分子图谱：来自RNA-NGS和生物信息学分析的见解
Petr Brož,Martina Strnadová,Denisa Olejníková et al.
Petr Brož et al.
Pediatric low-grade gliomas (pLGG) are the most common group of childhood brain tumors. Genetic alterations in the RAS-RAF-mitogen-activated protein kinase (MAPK) pathway are the molecular drivers in the vast majority of pLGG. A large propo...