PTEN Deletions Are Associated With Tumor Progression But Unrelated to Patient Prognosis in Muscle-Invasive Urothelial Bladder Carcinomas: A Large Multi-Center Validation Study on 2710 Urothelial Bladder Carcinomas [0.03%]
肌层浸润性膀胱尿路上皮癌中PTEN缺失与肿瘤进展相关但与患者预后无关：对2710例尿路上皮癌的大规模多中心验证研究
Martina Kluth,Henning Plage,Kira Furlano et al.
Martina Kluth et al.
The tumor suppressor gene PTEN plays an important role in many cancer types. Mechanism of PTEN inactivation includes gene mutations and deletions. In this large multi-center study, we analyzed the impact of PTEN deletions on tumor aggressiv...
Multicenter Study
Genes, chromosomes & cancer. 2026 Jan;65(1):e70105. DOI:10.1002/gcc.70105 2026
Biallelic NF1 Inactivation and Widespread Loss of Heterozygosity in a Subset of Unclassified Fibromyxoid Mesenchymal Neoplasms [0.03%]
NF1双等位基因失活和大片段杂合性丢失在部分未分类的纤维肌成肉瘤中的发生及其临床病理意义
Carla Saoud,Narasimhan Agaram,Samuel Singer et al.
Carla Saoud et al.
The integration of next generation sequencing into clinical practice has revolutionized the diagnosis of soft tissue tumors, enabling the discovery of novel tumor entities. We encountered a group of unclassified fibromyxoid mesenchymal neop...
Clear Cell Tumor With MITF::CREM Fusion: A Rare Case Report of a Newly Described Entity [0.03%]
MITF::CREM融合的透明细胞肿瘤：一种新描述实体的罕见病例报告
Michael Lie,Pranav Dorwal,Liyan Song et al.
Michael Lie et al.
The increasing application of molecular diagnostics in pathology has enabled the identification of novel tumor entities, including clear cell tumor with MITF::CREM translocation, as recognized in the 5th edition of the WHO Classification of...
Teresa Druck,Rami I Aqeilan,C Marcelo Aldaz et al.
Teresa Druck et al.
Wellcome Trust scientists have shown that "mutational signatures" in specific nucleotide contexts accumulate in genomes of mammalian tissues, providing clues to underlying causes of specific signatures. Analysis of cancer genomes has identi...
Molecular Landscape of TP53/RB1 Co-Altered Tumors Uncovers Emerging Therapeutic Vulnerabilities [0.03%]
TP53/RB1双突变肿瘤的分子图谱揭示了潜在的治疗弱点
Xuetao Li,Meifeng Ye,Xiaomei Huang et al.
Xuetao Li et al.
Background: Although TP53 and RB1 co-alterations play critical roles in promoting malignant development and progression, specific inhibitors targeting this co-alteration are lacking. We performed a pan-cancer analysis to ...
A Novel Targeted Sequence for Chromosome 11p15.5 Maternal Loss in SDHD-Related Paragangliomas [0.03%]
SDHD相关副神经节瘤染色体11p15.5母系丢失的新靶向序列
Huei-Pin Lai,Chen-Hui Lee,Hsuan Hu et al.
Huei-Pin Lai et al.
Hereditary paragangliomas (PGLs) caused by germline SDHD pathogenic variants (PVs) exhibit a parent-of-origin effect, with tumors arising almost exclusively when the PV is inherited from the paternal allele. The Hensen model proposes that a...
GLI1-Altered Mesenchymal Tumor of the Duodenum With a Novel TNFAIP3::GLI1 Gene Fusion: Report of a Diagnostically Challenging Case Associated With Late Metastasis [0.03%]
带有新型TNFAIP3::GLI1基因融合的十二指肠GLI1变异型间质瘤：与晚期转移相关的具有诊断挑战性的病例报告
Pedram Argani,He Fang,Yajuan J Liu et al.
Pedram Argani et al.
We report a GLI1-altered mesenchymal tumor of the duodenum with a novel TNFAIP3::GLI1 gene fusion, deceptive morphology, and late recurrence. The patient was a 72-year-old female who was found to have a polypoid 3.7 cm duodenal mass which, ...
Spatial Dynamics of Tumor Cell Plasticity in Lung Adenocarcinoma Revealed by Region-Specific Single Cell Transcriptomics [0.03%]
基于区域特异性单细胞转录组揭示肺癌细胞时空动态变化
Anna A Khozyainova,Maxim E Menyailo,Vera G Subrakova et al.
Anna A Khozyainova et al.
Tumor cell plasticity plays a key role in the progression of malignant neoplasms and therapy resistance, yet its spatial dynamics remain poorly understood. This study investigates the spatial distribution of epithelial-mesenchymal transitio...
The Role of RB1 and Secondary Genomic Changes in the Development of Spindle Cell and Pleomorphic Lipomas [0.03%]
RB1的作用及继发性基因组变化在梭形细胞和多形性脂肪瘤发生发展中的作用
Maria Hellberg,Valeria Difilippo,Emilia Gottberg et al.
Maria Hellberg et al.
Spindle cell lipomas (SCL) and pleomorphic lipomas (PL) are today considered a single tumor entity (SCLPL). Atypical SCLPL, in contrast, represents a recently recognized related but distinct entity. Here we explored the correlation between ...
Clinical and Pathologic Description of Three Aneurysmal Bone Cyst Cases With Novel USP6 Fusion Partners Including SEC24D, HNRNPC, and ERRFI1 [0.03%]
三个新型USP6融合伙伴包括SEC24D、HNRNPC和ERRFI1的动静脉骨囊肿的临床及病理特征描述
Patrick R Blackburn,Zonggao Shi,Maria F Cardenas et al.
Patrick R Blackburn et al.
Ubiquitin-specific protease 6 (USP6)-associated neoplasms constitute a spectrum of related entities that share clinical and morphological characteristics. They are defined molecularly by the presence of a USP6 gene rearrangement that result...