An overall characterization of pediatric acute lymphoblastic leukemia with CRLF2 overexpression [0.03%]
CRLF2扩增儿童急性淋巴细胞白血病的临床和基因特征分析
Mio Yano,Toshihiko Imamura,Daisuke Asai et al.
Mio Yano et al.
For an overall characterization of pediatric B-cell precursor acute lymphoblastic leukemia (BCPALL) with CRLF2 overexpression (OE), we conducted genetic analysis of CRLF2 in 167 pediatric BCPALL patients. CRLF2 OE was detected in 30 (18%) o...
Yaling Liu,Yu Zhou,Xiao Feng et al.
Yaling Liu et al.
Interstitial 13q14 deletions detected in the karyotype and translocations with concomitant deletion at 13q14 in chronic lymphocytic leukemia: different genetic mechanisms but equivalent poorer clinical outcome [0.03%]
染色体检查中慢性淋巴细胞白血病的13q14中间缺失及伴随13q14缺失的易位：不同的遗传机制，但临床结果同样较差
Anna Puiggros,Marta Venturas,Marta Salido et al.
Anna Puiggros et al.
Deletion of 13q14 as the sole abnormality is a good prognostic marker in chronic lymphocytic leukemia (CLL). Nonetheless, the prognostic value of reciprocal 13q14 translocations [t(13q)] with related 13q losses has not been fully elucidated...
Multicenter Study
Genes, chromosomes & cancer. 2014 Sep;53(9):788-97. DOI:10.1002/gcc.22188 2014
Near-haploidization significantly associates with oncocytic adrenocortical, thyroid, and parathyroid tumors but not with mitochondrial DNA mutations [0.03%]
近倍体化显著与线粒体DNA无关的肾上腺皮质、甲状腺和甲状旁腺肿瘤相关
Willem E Corver,Tom van Wezel,Kees Molenaar et al.
Willem E Corver et al.
Mitochondrial-rich oncocytic thyroid tumors frequently show near-haploidization and endoreduplication (masked haploidization), which manifests as a near-homozygous genome (NHG). We now extend this investigation to include adrenocortical can...
Ion Cristóbal,Oscar Aguilera,Jesús García-Foncillas et al.
Ion Cristóbal et al.
TET2 mutations in cytogenetically normal acute myeloid leukemia: clinical implications and evolutionary patterns [0.03%]
染色体正常的急性髓系白血病中TET2突变的临床意义及进化模式
Frederik Damm,Birgit Markus,Felicitas Thol et al.
Frederik Damm et al.
Mutations of the Ten-Eleven-Translocation 2 (TET2) gene have been identified in patients with various myeloid neoplasms, but the clinical relevance of these mutations and their timing during disease development in cytogenetically normal acu...
Multicenter Study
Genes, chromosomes & cancer. 2014 Oct;53(10):824-32. DOI:10.1002/gcc.22191 2014
Deep MicroRNA sequencing reveals downregulation of miR-29a in neuroblastoma central nervous system metastasis [0.03%]
深度微小核糖核酸测序显示神经母细胞瘤中枢神经系统转移中miR-29a表达下调
Irene Y Cheung,Thalia A Farazi,Irina Ostrovnaya et al.
Irene Y Cheung et al.
Central nervous system (CNS) is an increasingly common site of isolated metastasis for patients with Stage 4 neuroblastoma. To explore the microRNA (miRNA) profile of this metastatic process, miRNA sequencing was performed to identify miRNA...
Genetic variants in apoptosis-related genes associated with colorectal hyperplasia [0.03%]
与结直肠息肉相关的凋亡相关基因多态性分布规律研究
Stefano Gerola,Stefanie Nittka,Georg Kähler et al.
Stefano Gerola et al.
Deregulation of apoptosis is a frequent alteration in early benign lesions of the colon mucosa and is thought to be a major contributor to tumor progression and cancer. Single nucleotide polymorphisms (SNPs) within apoptosis-related genes c...
Meta-Analysis
Genes, chromosomes & cancer. 2014 Sep;53(9):769-78. DOI:10.1002/gcc.22185 2014
Anna Kwiecinska,Koichi Ichimura,Mattias Berglund et al.
Anna Kwiecinska et al.
To outline further genetic mechanisms of transformation from follicular lymphoma (FL) to diffuse large B-cell lymphoma (DLBCL), we have performed whole genome array-CGH in 81 tumors from 60 patients [29 de novo DLBCL (dnDLBCL), 31 transform...
Recurrent MYOD1 mutations in pediatric and adult sclerosing and spindle cell rhabdomyosarcomas: evidence for a common pathogenesis [0.03%]
儿童及成人硬化性和梭形细胞横纹肌肉瘤中反复出现的MYOD1基因突变：共同发病机制证据
Narasimhan P Agaram,Chun-Liang Chen,Lei Zhang et al.
Narasimhan P Agaram et al.
Sclerosing and spindle cell rhabdomyosarcoma (RMS) are rare types of RMS recently reclassified as a stand-alone pathologic entity, separate from embryonal RMS (ERMS). Although sclerosing and spindle cell RMS share clinical and morphologic f...