Global transcriptome and sequenome analysis of formalin-fixed salivary epithelial-myoepithelial carcinoma specimens [0.03%]
甲醛固定的小唾液腺肌上皮癌组织的转录组和序列分析
Isabel Fonseca,Achim Bell,Khalida Wani et al.
Isabel Fonseca et al.
Diverse microarray and sequencing technologies have been widely used to characterize molecular changes in malignant epithelial cells in salivary neoplasms. Such gene expression studies to identify markers and targets in tumor cells are, how...
Quantitative multigene FISH on breast carcinomas identifies der(1;16)(q10;p10) as an early event in luminal A tumors [0.03%]
定量多基因FISH分析发现乳腺导管癌中der(1;16)(q10;p10)为 Luminal A型肿瘤早期发生的事件
Inga H Rye,Pär Lundin,Susanne Månér et al.
Inga H Rye et al.
In situ detection of genomic alterations in cancer provides information at the single cell level, making it possible to investigate genomic changes in cells in a tissue context. Such topological information is important when studying intrat...
Immunophenotypic analysis reveals heterogeneity and common biologic aspects in monoclonal B-cell lymphocytosis [0.03%]
免疫表型分析揭示了单克隆B细胞淋巴细胞增多的异质性和共同生物学特征
Ioannis V Kostopoulos,Georgios Paterakis,Konstantinos Papadimitriou et al.
Ioannis V Kostopoulos et al.
Monoclonal B-cell lymphocytosis (MBL) is the presence of small B-cell clones in the peripheral blood of healthy subjects. Most MBL have the characteristic phenotype of chronic lymphocyte leukemia (chronic lymphocytic leukemia (CLL)-like MBL...
Genome-wide methylation analysis in vestibular schwannomas shows putative mechanisms of gene expression modulation and global hypomethylation at the HOX gene cluster [0.03%]
全基因组甲基化分析发现前庭神经鞘瘤中潜在的基因表达调控机制和HOX基因簇低甲基化现象
Miguel Torres-Martín,Luis Lassaletta,Jose M de Campos et al.
Miguel Torres-Martín et al.
Schwannomas are tumors that develop from Schwann cells in the peripheral nerves and commonly arise from the vestibular nerve. Vestibular schwannomas can present unilaterally and sporadically or bilaterally when the tumor is associated with ...
Homozygous deletions at 3p22, 5p14, 6q15, and 9p21 result in aberrant expression of tumor suppressor genes in gastric cancer [0.03%]
胃癌中位于3p22、5p14、6q15和9p21的纯合子缺失导致肿瘤抑制基因表达异常
Bona Lee,Kwiyeom Yoon,Sunghoon Lee et al.
Bona Lee et al.
Homozygous deletion is a frequent mutational mechanism of silencing tumor suppressor genes in cancer. Therefore, homozygous deletions have been analyzed for identification of tumor suppressor genes that can be utilized as biomarkers or ther...
Telomere length in circulating lymphocytes: Association with chromosomal aberrations [0.03%]
循环淋巴细胞端粒长度与染色体异常的关系
Kari Hemminki,Sivaramakrishna Rachakonda,Ludovit Musak et al.
Kari Hemminki et al.
Novel oncogene and tumor suppressor mutations in KIT and PDGFRA wild type gastrointestinal stromal tumors revealed by next generation sequencing [0.03%]
新一代测序技术揭示KIT和PDGFRA野生型胃肠道间质瘤中的新的原癌基因及肿瘤抑制因子突变
Jaclyn Frances Hechtman,Ahmet Zehir,Talia Mitchell et al.
Jaclyn Frances Hechtman et al.
Among gastrointestinal stromal tumors (GISTs) of 10-15% are negative for KIT and PDGFRA, and most of these cases are SDH deficient. Recent studies have provided data on additional molecular alterations such as KRAS in KIT mutant GISTs. We a...
Gemma Macchia,Karolin H Nord,Monica Zoli et al.
Gemma Macchia et al.
Gene amplification is relatively common in tumors. In certain subtypes of sarcoma, it often occurs in the form of ring and/or giant rod-shaped marker (RGM) chromosomes whose mitotic stability is frequently rescued by ectopic novel centromer...
An evaluation and recommendation of the optimal methodologies to detect RET gene rearrangements in papillary thyroid carcinoma [0.03%]
评估和推荐检测乳头状甲状腺癌中RET基因重排的最佳方法学
Tianwei Zhang,Yachao Lu,Qingqing Ye et al.
Tianwei Zhang et al.
To recommend a reliable and clinically realistic RET/PTC rearrangement detection assay for papillary thyroid carcinoma (PTC), we compared multiplex quantitative polymerase chain reaction (qPCR), fluorescence in situ hybridization (FISH), an...
Association of the chromodomain helicase DNA-binding protein 4 (CHD4) missense variation p.D140E with cancer: potential interaction with smoking [0.03%]
组蛋白修饰酶CHD4的错义突变p.D140E与吸烟协同增加癌症风险及潜在机制研究
Miki Yamada,Noriko Sato,Shinobu Ikeda et al.
Miki Yamada et al.
Chromodomain helicase DNA-binding protein 4 (CHD4) plays a pivotal role in chromatin-remodeling and has been implicated in the development of cancer. The aim of this study is to determine the association of CHD4 gene variants with cancer. N...