Nooshin K Dashti,George Matcuk,Abbas Agaimy et al.
Nooshin K Dashti et al.
Conventional high-grade osteosarcomas are characterized by aggressive radiologic features, cytologic pleomorphism, and complex genomics. However, rare examples of osteosarcomas remain challenging due to unusual histology, such as sclerosing...
Epigenetic Modeling of Jumping Translocations of 1q Heterochromatin in Acute Myeloid Leukemia After 5'-Azacytidine Treatment [0.03%]
5-氮杂胞苷治疗后急性髓系白血病中1q异染色质跳跃易位的表观遗传学建模
Anair Graciela Lema Fernandez,Carlotta Nardelli,Valentina Pierini et al.
Anair Graciela Lema Fernandez et al.
Jumping translocations (JT) are rare cytogenetic abnormalities associated with progression in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). Typically, a tri-tetra-somic 1q chromosome is translocated to two or more recipi...
Shuhao Fan,Jianhua Guo,Hui Nie et al.
Shuhao Fan et al.
Energy metabolic reprogramming is frequently observed during tumor progression as tumor cells necessitate adequate energy production for rapid proliferation. Although current medical research shows promising prospects in studying the charac...
Fibromyxoid aSoft Tissue Tumor With PLAG1 Fusion-The First Case in an Adult Patient [0.03%]
PLAG1重排的纤维肌瘤样软组织肿瘤-首例成人患者病例报告
M Strnadová,J Balko,P Brož et al.
M Strnadová et al.
With the expanding possibilities of human genome research in recent years, the number of cases of soft tissue tumors that we are able to classify into the correct subgroups and to reveal their molecular profile is increasing. Among such tum...
An Inflammatory Myofibroblastic Tumor With a Novel ALKV1180L Mutation Leading to Acquired Resistance to Tyrosine Kinase Inhibitors [0.03%]
携带新型ALKV1180L突变的炎性肌纤维母细胞瘤对酪氨酸激酶抑制剂产生获得性耐药的一例
Brittney Sharpe,Donald C Green,Laura J Tafe et al.
Brittney Sharpe et al.
Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal neoplasm that can locally recur and potentially metastasize. Approximately 50% of IMTs harbor rearrangements in the gene encoding anaplastic lymphoma kinase (ALK), a receptor ty...
Novel HMGA2::COL14A1 Fusion Identified in Xanthogranulomatous Epithelial Tumor/Keratin-Positive Giant Cell Tumor [0.03%]
Xanthogranulomatous上皮肿瘤/角蛋白阳性巨细胞瘤中发现的新融合基因HMGA2::COL14A1
Carina A Dehner,Darya Buehler,Christopher Hofich et al.
Carina A Dehner et al.
Xanthogranulomatous epithelial tumor (XGET)/Keratin-positive giant cell tumor (KP-GCT) represents a spectrum of recently described neoplasms characterized by a proliferation of distinctive mononuclear cells expressing keratin within a backg...
Chikako Sato,Masanaka Sugiyama,Taisuke Mori et al.
Chikako Sato et al.
MN1 fusion is emerging as oncogenic in soft-tissue tumors. Here, we provided detailed clinicopathological documentation of a tumor with MN1::TAF3 fusion. The tumor developed on the face of an 8-year-old boy and did not recur or metastasize ...
GLI1, CDK4, and MDM2 Co-Amplification Gastric Plexiform Fibromyxoma: A Case Report and Literature Review [0.03%]
GLI1、CDK4和MDM2共扩增胃plexiform fibromyxoma的病例报告及文献回顾
Shihui Zhang,Ye Yang,Jianwei Li et al.
Shihui Zhang et al.
Plexiform fibromyxoma (PF) is a rare mesenchymal tumor that primarily occurs in gastric origin with a benign behavior. PF commonly harbors the MALAT1::GLI1 fusion gene. Here, we describe a case of a 36-year-old female with a PF. Abdominal c...
Differential Expression of Proteins and Genes at the Tumor-Brain Interface in Invasive Meningioma [0.03%]
侵袭性脑膜瘤中肿瘤-大脑界面的蛋白质和基因差异表达
Kornwika Senglek,Chinachote Teerapakpinyo,Nutchawan Jittapiromsak et al.
Kornwika Senglek et al.
Most meningiomas are dural-based extra-axial tumors in close contact with the brain. Expression of genes and proteins at the tumor-brain interface in brain-invasive meningioma is basically unknown. Using the NanoString pan-cancer panel, dif...
Sporadic Breast Angiosarcoma With MYC Amplification on Extrachromosomal Circular DNA Detected Using Nanopore Sequencing in an Adolescent Female [0.03%]
纳米孔测序检测外染色体环状DNA扩增的青少年女性散发性乳腺血管肉瘤（MYC）1例报告
Naohiro Makise,Jason Lin,Hajime Kageyama et al.
Naohiro Makise et al.
Angiosarcoma (AS) is a malignant vascular neoplasm comprising neoplastic endothelial cells accounting for 1%-4% of soft tissue sarcomas. While lymphedema-associated and post-irradiation ASs are almost always driven by a high-level amplifica...