Schwann Cells Deficient in Neurofibromin Lack Sensitivity to Their Biomechanical Microenvironment [0.03%]
缺乏神经纤维蛋白的施万细胞对其生物力学微环境没有反应
Micah Rambo,Isheka Agarwala,Camdyn Vanek et al.
Micah Rambo et al.
Background and aims: Plexiform neurofibromas (PNFs) are benign tumors of the peripheral nervous system that affect approximately 30% of people with neurofibromatosis type 1 (NF1). Schwann cells (SCs), the tumor progenitor...
A MAZ::NCOA2 Subcutaneous Small Round Cell Sarcoma of Infancy With Diffuse S100/SOX10 Positivity: A Novel Entity [0.03%]
儿童期MAZ::NCOA2亚型皮下小圆形细胞肉瘤伴弥漫性S100/SOX10阳性：一种新型病变
Huiyao Chen,Pu Zhang,Lingli Zhou
Huiyao Chen
Small round cell sarcomas (SRCSs) constitute a heterogeneous group of high-grade tumors with a poor prognosis, predominantly affecting children and young adults. According to the 2020 WHO Soft Tissue Tumor classification, SRCSs are categori...
Roope A Kallionpää,Juha Määttänen,Jussi Leppävirta et al.
Roope A Kallionpää et al.
Background: Neurofibromatosis type 1 (NF1) is associated with a high risk for cancer. Benign cutaneous neurofibromas of women with NF1 may increase in size and number during pregnancy. However, it is not known whether pre...
Anfeng Jiang,Huan Li,Dongbing Li et al.
Anfeng Jiang et al.
Background: Kinase-rearranged spindle cell sarcomas are characterized by unique molecular features. The advent of next-generation sequencing (NGS) has enabled the detection of a multitude of kinase fusions, thereby contri...
PDGFRA::USP8 Fusion in a Cutaneous Inflammatory Myofibroblastic Tumor, Highlighting Genetic Pleiotropy of Kinase Gene Fusions in Soft Tissue Neoplasms [0.03%]
皮肤炎症性肌成纤维细胞肿瘤中的PDGFRA::USP8融合，强调了软组织肿瘤中激酶基因融合的遗传多效性
Astrid I P Vernemmen,Léon C L T van Kempen,Frits Aarts et al.
Astrid I P Vernemmen et al.
USP8 fusions have recently been described in neoplasms in the provisional category of calcified chondroid mesenchymal neoplasm (CCMN). Here, we describe a cutaneous inflammatory myofibroblastic tumor (IMT) on the upper leg of a 24-year-old ...
Challenging Conventional Perceptions of Oncogenes and Tumor Suppressor Genes: A Comprehensive Analysis of Gene Expression Patterns in Cancer [0.03%]
挑战人们对癌基因和抑癌基因的传统认识：癌症中基因表达模式的全面分析
Mingyuan Zou,Li Qiu,Wentao Wu et al.
Mingyuan Zou et al.
Identifying genes involved in cancer is crucial for understanding the underlying molecular mechanisms of the disease and developing effective treatment strategies. Differential expression analysis (DEA) is the predominant method used to ide...
Profiling Precursor microRNAs of Breast Cancer From Total RNA Sequencing Data to Gain Insights Into Their Roles and Prognostic Values [0.03%]
从总RNA测序数据中分析乳腺癌前体microRNAs以探讨其作用及预后价值
Sen Wu,Jia-Wern Pan,Marimuthu Citartan et al.
Sen Wu et al.
Breast cancer, a molecularly heterogeneous disease, is classified into hormone receptor-positive luminal breast cancer (LBC), human epidermal growth factor receptor 2-positive breast cancer, and triple-negative breast cancer (TNBC). Precurs...
Influence of Cytogenetics on the Outcome of Patients With High-Risk Myelodysplastic Syndrome Including Deletion 5q Treated With Azacitidine With or Without Lenalidomide [0.03%]
染色体遗传学对高危骨髓增生异常综合征患者阿扎胞苷联合来那度胺或单用阿扎胞苷治疗预后的影响：包括5号染色体缺失在内的影响
Bengt Rasmussen,Lars Nilsson,Magnus Tobiasson et al.
Bengt Rasmussen et al.
In myelodysplastic syndromes (MDS), cytogenetic characteristics of the malignant bone marrow cells influence the clinical course. The aim of this study was to evaluate whether cytogenetics is useful to predict outcome and response in patien...
Clinical Trial
Genes, chromosomes & cancer. 2025 Feb;64(2):e70029. DOI:10.1002/gcc.70029 2025
Spindle Cell Sarcoma With Novel JAZF1::NUDT5 Gene Fusion: Report of a Previously Undescribed Neoplasm [0.03%]
具有新颖JAZF1::NUDT5基因融合的梭形细胞肉瘤一种先前未描述的肿瘤报告
Rebecca Fliorent,Syed T Hoda,George Jour et al.
Rebecca Fliorent et al.
Gene fusions involving JAZF1 are a recurrent event in low grade endometrial stromal sarcoma, and have been more recently described in few instances of endometrial stromal sarcoma-like tumors in the genitourinary tract of men. In this articl...
Novel PDGFRB Gene Fusions in Two Cases of Infantile Myofibromatosis [0.03%]
PDGFRB基因重排在婴幼儿肌纤维母细胞瘤中的研究两项研究ollectorsignonollectors
Federica Boccia,Sabina Barresi,Silvia Vallese et al.
Federica Boccia et al.
Infantile myofibromatosis (IM) comprises a wide clinical spectrum, ranging from solitary or multicentric lesions to generalized life-threatening forms. IM is mostly linked to germline or somatic heterozygous mutations in the PDGFRβ tyrosin...