Jacob de Bakker,Hedde Biesma,Tanya Soeratram et al.
Jacob de Bakker et al.
Introduction: The molecular and histological characteristics of primary duodenal adenocarcinoma (DA) have been poorly described, which hampers the development of new treatment options. This study aimed to characterize the...
EWSR1 Rearrangements in Basaloid Neoplasms With Adnexal Differentiation [0.03%]
具有附属器分化的基底样肿瘤中的EWSR1重排
Carina A Dehner,Shruti Agrawal,Baptiste Ameline et al.
Carina A Dehner et al.
Various cutaneous adnexal neoplasms have been associated with gene fusions as the main driver of their histogenesis, most of which showed poroid or hidradenomatous differentiation or represented other tumors of sweat glands. Recently, we en...
Clinicopathologic and Molecular Analysis of Primary Angiosarcoma of Bone-A Single Institution Experience [0.03%]
原发性骨血管肉瘤的临床病理和分子分析：单中心经验报告
Takeshi Hirose,Hsin-Yi Chang,Robert A Lefkowitz et al.
Takeshi Hirose et al.
Purpose: Bone angiosarcoma (B-AS) is an exceedingly rare and aggressive vascular neoplasm, with limited therapeutic options and poor outcomes. Unlike the more prevalent clinical subsets (breast, head and neck), the pathog...
Epithelioid Inflammatory Myofibroblastic Sarcoma: Case Series With a First Report of CLTC::ALK Fusion in an Aggressive Disease [0.03%]
上皮样炎性肌纤维母细胞瘤的病例系列及CLTC::ALK融合在侵袭性疾病中的首次报道
Daisy Maharjan,Carina Dehner,Ali Alani et al.
Daisy Maharjan et al.
Epithelioid inflammatory myofibroblastic sarcoma (EIMS) is a rare and clinically aggressive variant of inflammatory myofibroblastic tumor (IMT). It typically presents in children and young adults, often affecting the abdominal cavity. It is...
Novel ACTB::FER Promoter Swap Fusion Characterizes Rare Superficial Myoid/Myofibroblastic Tumors [0.03%]
新型ACTB::FER融合基因表征罕见的上皮肌样/肌纤维母细胞肿瘤
Patrick R Blackburn,Mohammad K Eldomery,Victor Pastor Loyola et al.
Patrick R Blackburn et al.
Pediatric fibroblastic, myofibroblastic, and myoid tumors encompass several entities, many with characteristic gene fusions that are now emerging as molecularly defined tumor groups. Here, we present two cases of spindle cell neoplasms with...
Paratesticular Endometrial Stromal Sarcoma-Like Sarcoma With EPC1-SUZ12 Fusion [0.03%]
带有EPC1-SUZ12融合的附睾旁类子宫内膜间质肉瘤样肉瘤
Paul E Rosenstiel,Kyle Meinke,John Lavin
Paul E Rosenstiel
Endometrial stromal sarcoma-like (ESS-like) sarcomas have rarely been described in male patients and represent a subset of "Mullerian analog" tumors. These ESS-like sarcomas most commonly arise in the paratesticular or pelvic regions and of...
Distinct Signatures of Chromosomal Involvement in 59 251 Translocations Across 58 Tumor Types. A Novel Perspective [0.03%]
染色体异常在58种肿瘤类型的251种易位中的特异性特征。一种新颖的视角
Felix Mitelman,Nils Mandahl
Felix Mitelman
Chromosomal translocations are key events in cancer, driving oncogenesis by disrupting and deregulating critical genes. While specific tumor-associated translocations are well studied, the frequencies and distributions of most remain unknow...
Single-Cell Profiling of Mononuclear Cells Identifies Transcriptomics Signatures Differentiating Prostate Cancer From Benign Prostatic Hyperplasia [0.03%]
单细胞分析鉴定出区分前列腺癌和良性前列腺增生的转录组标志物
Kadriia Enikeeva,Vyacheslav Korobeynikov,Yuliya Sharifyanova et al.
Kadriia Enikeeva et al.
Prostate cancer (PCa) and benign prostatic hyperplasia (BPH) share overlapping etiological factors but differ molecularly. In the study, 4 patients with prostate cancer and 3 patients with BPH were included. All patients with prostate cance...
High-Grade Uterine Sarcoma: First Report of a MEIS2::FOXO4 Fusion [0.03%]
高级别子宫肉瘤：首次报告MEIS2::FOXO4融合基因阳性案例
Gulisa Turashvili,Edwin Choy,Adam S Fisch et al.
Gulisa Turashvili et al.
Uterine sarcomas are uncommon mesenchymal neoplasms ranging from low- to high-grade or undifferentiated. High-grade sarcomas are characterized by various morphologic, immunohistochemical, and molecular alterations. Here, we report the first...