YAP1::KMT2A-Rearranged Sarcoma: Report of a New Case With Unusual Morphology and Immunohistochemical Features [0.03%]
YAP1::KMT2A重排肉瘤：一例具有不典型形态和免疫组化特征的新病例报告
Caterina Fumagalli,Ruth Orellana,Sílvia Bagué et al.
Caterina Fumagalli et al.
Recurrent KMT2A and YAP1 related fusions have recently been reported in various mesenchymal neoplasms of different histogenesis. First, YAP1::KMT2A fusions have been described in a subset of MUC4-negative sclerosing epithelioid fibrosarcoma...
PLAG1-Rearranged Fibromyxoid and Lipomatous Neoplasms in Children and Adults: Separate Entities or a Morphological Spectrum? [0.03%]
儿童和成人PLAG1重排的纤维黏液样和脂肪瘤样肿瘤：独立实体还是形态学谱系？
Vanghelita Andrei,Elena Zheleznyakova,Silvia Cavalchini et al.
Vanghelita Andrei et al.
Fusions involving the PLAG1 gene are associated with multiple cancers and benign tumors, including lipoblastoma and the more recently described pediatric fibromyxoid soft tissue tumor. We report two PLAG1-rearranged mesenchymal tumors arisi...
Widening the Spectrum of Fusion Events in Schwannoma: Identification of a Novel TANC1::HTRA1 Fusion [0.03%]
schwannoma融合事件谱的扩增：鉴定出一种新的TANC1 :: HTRA1融合
James A Watkins,Patrick Tarpey,Maria O&#x;Donovan et al.
James A Watkins et al.
A range of genomic drivers have been identified in schwannomas, including a number of translocations, most commonly SH3PXD2A::HTRA1. To date, despite the analysis of large numbers of cases, no examples of variant HTRA1 partners have been de...
Pseudoglandular Schwannoma With FUS::KLF17 Fusion: Broadening the Spectrum of FUS-Associated Tumors [0.03%]
具有FUS::KLF17融合的假腺性施万细胞瘤：扩大FUS相关肿瘤的谱系范围
Jerome Givi,Daisy Wu,Rania Bakkar et al.
Jerome Givi et al.
We present a case of a 51-year-old male with a pseudoglandular cellular schwannoma arising from the brachial plexus, which contains the expected molecular aberrations for a schwannoma (chromosome 22q loss encompassing the NF2 and LZTR1 gene...
CD34-Positive Acral Chondromyxoid Mesenchymal Neoplasm Harboring a Novel TCF4::ERG Fusion [0.03%]
一种新的TCF4::ERG融合基因阳性CD34阳性指（趾）部软骨粘液纤维母细胞肿瘤
Eric C Honaker,Laura M Warmke,Ameline Baptiste et al.
Eric C Honaker et al.
Molecular testing has significantly transformed the field of anatomic pathology over the past several decades. Despite these advances, acral mesenchymal neoplasms remain diagnostically challenging, requiring careful integration of clinical ...
Uterine Myxoid Mesenchymal Tumor With a Novel SS18::VEZF1 Gene Fusion, Lacking Worrisome Histological Features [0.03%]
一种新型SS18::VEZF1基因融合子宫粘液样间叶源性肿瘤的病例报告：缺乏组织学恶性的特征
Isidro Machado,Reyes Claramunt,Susana López et al.
Isidro Machado et al.
We report a uterine myxoid mesenchymal tumor with a novel SS18::VEZF1 gene fusion. The current lesion was identified in a 53-year-old woman who presented with symptomatic "fibroids" showing accelerated growth and heterogeneous morphology on...
Yamato Suemitsu,Hsin-Yi Chang,Carla Saoud et al.
Yamato Suemitsu et al.
Extraskeletal myxoid chondrosarcoma (EMC) is a rare mesenchymal neoplasm of uncertain histogenesis, characterized by recurrent gene fusions involving NR4A3 with various gene partners (EWSR1, TAF15, FUS, etc.). Although the impact of fusion ...
Macroscopic Monozygotic Androgenetic/Biparental Mosaicism: Molecular Characterization and Clinical Implications [0.03%]
单卵孪生嵌合体的分子特征及临床意义研究进展
H Usui,N Nakamura,E Katayama et al.
H Usui et al.
Hydatidiform moles represent abnormal pregnancies characterized by trophoblastic hyperproliferation. However, accurate diagnosis of partial hydatidiform moles (PHM) remains challenging. We present a rare case of a monozygotic androgenetic/b...
Comprehensive mRNA Expressional Analysis of SMARCB1-Deficient Renal Cell Carcinoma in Patients Without Hemoglobinopathies [0.03%]
无血红蛋白病患者的SMARCB1缺陷性肾细胞癌的全面mRNA表达分析
Daisuke Kiyozawa,Genshiro Fukuchi,Takumi Miyamoto et al.
Daisuke Kiyozawa et al.
The molecular characteristics of switch/sucrose non-fermentable-related BAF chromatin remodeling complex subunit B1 (SMARCB1)-deficient renal cell carcinoma (RCC), particularly in patients without any hemoglobinopathies, remain unknown. Fur...
Tr-KIT Downstream Regulation by YY1 and NFYA Transcription Factors Knockdown in Prostate Cancer Cells [0.03%]
前列腺癌细胞中YY1和NFYA转录因子的敲低对Tr-KIT下游调节的影响
Sercan Ergun,Ferda Arı,Erdal Benli et al.
Sercan Ergun et al.
Background: Prostate cancer is a common and deadly cancer among men and has been the subject of many patients in its diagnosis and treatment. Imatinib, a tyrosine kinase inhibitor, can slow tumor formation by targeting c-...