Expanding the Spectrum of SRF-Rearranged Myoid Tumors: An Adult Case With SRF::SOHLH1 Fusion and Suspected Metastasis [0.03%]
SRF重排肌样肿瘤的谱系扩大：一例成人SRF::SOHLH1融合基因阳性肿瘤伴疑似转移病例报告
Mohamed Elmoryah,Fatima B Ergen,John M Skaugen et al.
Mohamed Elmoryah et al.
IGH::IL3-Rearranged B-Cell Precursor Acute Lymphoblastic Leukemia With Hypereosinophilia in a Child With a Novel PAX5 Germline Variant [0.03%]
伴有新型PAX5基因组变异的儿童IGH :: IL3重排B细胞前体急性淋巴细胞白血病合并嗜酸性粒细胞增多症
Bartosz Urbański,Karolina Miarka-Walczyk,Zuzanna Urbańska et al.
Bartosz Urbański et al.
B-cell precursor acute lymphoblastic leukemia (BCP-ALL) with the t(5;14)(q31;q32) chromosomal translocation resulting in an IGH::IL3 fusion is an exceptionally rare lymphoid malignancy presenting with hypereosinophilia. Germline PAX5 altera...
Cytogenetic and Molecular Genetic Driven Prediction of Response to First-Treatment and Prognosis in Acute Myeloid Leukemia: A Retrospective Cohort Study [0.03%]
急性髓系白血病初治疗效和预后的细胞遗传学和分子生物学驱动的预测：回顾性队列研究
Henan Zhang,Xuan Liu,Xiaoning Wang et al.
Henan Zhang et al.
Background: The first induction therapy is critical in determining subsequent treatment strategies and patient outcomes in acute myeloid leukemia (AML). This study aimed to comprehensively analyze the genetic landscape of...
NFATC2::NUTM2A/B Fusions Characterize a Novel Indolent Myoepithelial-Like Neoplasm of the Lungs and Salivary Glands [0.03%]
肺和唾液腺惰性肌上皮样肿瘤的新型融合基因NFATC2::NUTM2A/B特征
Abbas Agaimy,Josephine K Dermawan,Elisabete Rios et al.
Abbas Agaimy et al.
With the increasing use of next-generation sequencing, the classification of heretofore unclassified neoplasms is evolving rapidly. Specifically, gene fusions have emerged as context-specific defining genetic markers for an increasing numbe...
BCOR-Mutated Conventional and Dedifferentiated Chondrosarcoma: A Clinicopathologic Study [0.03%]
BCOR突变的常规型和去分化的软骨肉瘤：临床病理研究
Diego M Montoya-Cerrillo,Mark G Evans,Andrew Elliott et al.
Diego M Montoya-Cerrillo et al.
Conventional and dedifferentiated chondrosarcoma encompass a group of malignant neoplasms that produce cartilaginous matrix and arise within or on the surface of bone. Conventional chondrosarcomas are graded on a three-tiered scale, whereas...
Zhigan Wang,Ying Zhang,Mingxing Zhu et al.
Zhigan Wang et al.
KMT2A-rearranged sarcomas represent a heterogeneous group of tumors with clinical behaviors ranging from surgical cure to local recurrence and metastasis. Previously reported fusion partners include YAP1 and VIM: YAP1::KMT2A::YAP1 is associ...
Type B3 Thymoma With a Novel KMT2A::MAML3 Fusion: Expanding the Spectrum of Gene Fusions Beyond the MAML2 Gene [0.03%]
一种新型KMT2A::MAML3融合的B3胸腺瘤：超越MAML2基因扩展基因重排类型
Ziqi Zhou,Yanqi Yu,Conghao Chen et al.
Ziqi Zhou et al.
Mastermind-like transcriptional coactivator (MAML) gene fusions have been documented in Thymic Epithelial Tumors (TETs). Specifically, lysine methyltransferase 2A (KMT2A)::MAML2 gene fusions are associated with type B2 and B3 thymomas. Here...
Adult Type Lipoblastoma With a Predominantly Fibroblastic Morphology and a Novel DLEU2::PLAG1 Gene Rearrangement: Two Cases of a Rare Entity [0.03%]
罕见的成人型脂母细胞瘤伴以纤维结缔组织样形态为主的新型DLEU2::PLAG1基因重排两例报告
Tyler Steidl,Michael Michal,David I Suster
Tyler Steidl
Lipoblastoma is a benign adipocytic lesion with embryonal fat cell differentiation. The tumors most commonly occur in children, however, rare cases have been reported to occur in adults and are generally considered to represent "maturing" o...
Comparative DNA Methylation Profiling of Human and Murine ALK-Positive B-Cell Neoplasms [0.03%]
人类和鼠ALK阳性B细胞肿瘤的DNA甲基化谱比较分析
Selina Glaser,Rabea Wagener,Shannon K Harkins et al.
Selina Glaser et al.
Structural genomic variants leading to anaplastic lymphoma kinase (ALK) gene fusions and aberrant expression of the ALK tyrosine kinase are the hallmark of subtypes of T- and B-lineage neoplasms, namely ALK-positive anaplastic large lymphom...
Comparative Study
Genes, chromosomes & cancer. 2025 Jul;64(7):e70060. DOI:10.1002/gcc.70060 2025
TFE3-Altered Perivascular Epithelioid Cell Tumour (PEComa) of the Nasal Cavity With a Novel TRAF3::TFE3 Fusion-A Report of a Case Expanding the Molecular Genetic Spectrum and a Brief Literature Review on PEComas of the Head and Neck Region [0.03%]
鼻腔TFE3重排的平滑肌瘤病变(perivascular上皮细胞肿瘤(PEComa))一例及其文献复习
Zhengyu Samuel Chua,Michael Michal,Fredrik Petersson
Zhengyu Samuel Chua
Background: Perivascular epithelioid cell tumours (PEComas) constitute a unique group of neoplasms with a distinctive myomelanocytic immunohistochemical phenotype and uncommonly occur in the head and neck region. We herei...