Genistein inhibits DNA methylation and increases expression of tumor suppressor genes in human breast cancer cells [0.03%]
染料木素通过抑制DNA甲基化增加人类乳腺癌细胞中抑癌基因的表达
Qi Xie,Qian Bai,Ling-Yun Zou et al.
Qi Xie et al.
It has been previously demonstrated that genistein exhibits anticancer activity against breast cancer. However, the precise mechanisms underlying the anticancer effect of genistein, in particular the epigenetic basis, remain unclear. In thi...
Low expression of microRNA-126 is associated with poor prognosis in colorectal cancer [0.03%]
microRNA-126低表达与结直肠癌不良预后有关
Yaling Liu,Yu Zhou,Xiao Feng et al.
Yaling Liu et al.
MicroRNA-126 (miR-126) has been reported to be a tumor suppressor that targets CXCR4 in colorectal cancer (CRC) cells. This study investigated whether miR-126 has any prognostic impact in patients with CRC. MiR-126 and CXCR4 mRNA expression...
Complementary molecular approaches reveal heterogeneous CDH1 germline defects in Italian patients with hereditary diffuse gastric cancer (HDGC) syndrome [0.03%]
互补的分子方法揭示了意大利遗传性弥漫性胃癌综合征患者中异质性的CDH1基因组缺陷
Valeria Molinaro,Valeria Pensotti,Monica Marabelli et al.
Valeria Molinaro et al.
Germline inactivation of the E-cadherin gene (CDH1) is associated with hereditary diffuse gastric cancer (HDGC), a rare autosomal dominant syndrome predisposing to both diffuse gastric cancer (DGC) and lobular breast cancer (LBC). We search...
Multicenter Study
Genes, chromosomes & cancer. 2014 May;53(5):432-45. DOI:10.1002/gcc.22155 2014
Association of the type of 5q loss with complex karyotype, clonal evolution, TP53 mutation status, and prognosis in acute myeloid leukemia and myelodysplastic syndrome [0.03%]
染色体5q丢失的类型与急性髓系白血病和骨髓增生异常综合征中复杂核型、克隆进化、TP53基因突变状态及预后的关系
Sarah Volkert,Alexander Kohlmann,Susanne Schnittger et al.
Sarah Volkert et al.
We analyzed 1,200 patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) harboring a 5q deletion in order to clarify whether the type of 5q loss is associated with other biological markers and prognosis. We investigat...
Clear cell sarcoma of the kidney demonstrates an embryonic signature indicative of a primitive nephrogenic origin [0.03%]
透明细胞肾癌的胚胎谱特征表明其起源于原始肾生殖细胞
Jenny Karlsson,Linda Holmquist Mengelbier,Cristina D Ciornei et al.
Jenny Karlsson et al.
Clear cell sarcoma of the kidney (CCSK) is a tumor affecting children with a median age of 3 years at diagnosis. The cell of origin of CCSK is unknown and data on the molecular changes giving rise to CCSK is scarce. This has hindered the id...
Metastatic signature in lung cancer is associated with sensitivity to anti-integrin α(V) monoclonal antibody intetumumab [0.03%]
肺癌的转移标志与抗整合素α(v)单克隆抗体intetumumab敏感性相关性研究
Huiqing Liu,Jaehong Park,Carol Manning et al.
Huiqing Liu et al.
Intetumumab is a fully human monoclonal antibody that inhibits αv integrins. It has been shown in in vitro assays to effectively inhibit cell viability, metastasis, and adhesion of human cancer cells and endothelial cells. However, the res...
Expression of stress-induced phosphoprotein1 (STIP1) is associated with tumor progression and poor prognosis in epithelial ovarian cancer [0.03%]
应激诱导磷酸蛋白1(STIP1)表达与上皮性卵巢癌进展及预后不良有关
Hanbyoul Cho,Sunghoon Kim,Ha-Yeon Shin et al.
Hanbyoul Cho et al.
Stress-induced phosphoprotein1 (STIP1) is a candidate biomarker in epithelial ovarian cancer (EOC). In this study, we investigated in detail the expression of STIP1, as well as its functions, in EOC. STIP1 expression was assessed by immunoh...
A selected group of large common fragile site genes have decreased expression in oropharyngeal squamous cell carcinomas [0.03%]
选择性扩增的大共济基因在口腔扁平上皮细胞癌中表达降低
Ge Gao,Jan L Kasperbauer,Nicole M Tombers et al.
Ge Gao et al.
The common fragile sites (CFSs) are large regions of profound genomic instability found in all individuals. The frequent deletions and other alterations in these regions in multiple cancers has led to the discovery of a number of extremely ...
Choroid plexus carcinomas are characterized by complex chromosomal alterations related to patient age and prognosis [0.03%]
脉络丛癌的复杂染色体重排与其患者的年龄和预后相关
Vincent Ruland,Stefan Hartung,Uwe Kordes et al.
Vincent Ruland et al.
Choroid plexus carcinoma is a malignant brain tumor predominantly occurring in young children. Only limited data are available regarding the underlying molecular genetic alterations. Therefore, molecular inversion probe single nucleotide po...