WWP2 Overexpression Represses NLRP3 Inflammasome Activation in Cerebral Ischemia/Reperfusion Injury Through the Degradation of MAVS [0.03%]
WWP2过表达通过降解MAVS抑制脑缺血再灌注损伤中的NLRP3炎性小体活化
Hang Yu,Jinghao Li,Tingting Lu et al.
Hang Yu et al.
NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome plays a pivotal role in the progression of cerebral ischemia/reperfusion injury (CI/RI). We aimed to investigate the implication of WW domain-containing protein 2 (WWP2),...
Unraveling the Role of Ensheathing Cells and Perineural Fibroblasts in Olfactory Neurogenesis [0.03%]
包裹细胞和周神经纤维母细胞在嗅觉神经发生中的作用机制研究
Katja Senf,Sandor Nietzsche,Martin Westermann et al.
Katja Senf et al.
During development and following injury-induced neurogenesis, olfactory ensheathing cells (OECs) envelope the axon bundles of sensory neurons and support their growth to the glomerular destinations in the olfactory bulb. Transplantation of ...
Glia Preserve Their Own Functions While Compensating for Neighboring Glial Cell Dysfunction [0.03%]
少突胶质细胞能够补偿邻近细胞的功能异常以保障自身功能的正常发挥
Allison N Beachum,Gabriela Salazar,Amelia Nachbar et al.
Allison N Beachum et al.
Glial cells are essential for nervous system development, homeostasis, and disease response, engaging in close interactions with neurons and other glial cells to carry out their functions. A large focus of glial studies has been on investig...
AAV-Based Intracerebral Administration of BDNF Promotes Myelin Repair and Cognitive Improvement After Cuprizone-Induced Demyelination [0.03%]
基于AAV的BDNF脑内给药促进杯rizone诱导的脱髓鞘后少突胶质细胞介导的髓鞘修复及认知改善作用研究
Yousra El Ouaamari,Leonardo Ricciardi,Sanne van der Heijden et al.
Yousra El Ouaamari et al.
Multiple sclerosis (MS) is a chronic neurological disorder involving immune-mediated demyelination and neurodegeneration in the central nervous system (CNS). Current therapies primarily target inflammation, with limited strategies to promot...
Selective Deletion of NBCe1 in Reactive Astrocytes Attenuates Ischemic Stroke Brain Damage [0.03%]
选择性删除NBCe1缓解反应性星形胶质细胞在缺血性脑卒中的脑损伤作用
Okan Capuk,Elise Berthold,Kathiravan Kaliyappan et al.
Okan Capuk et al.
The electrogenic sodium bicarbonate transporter 1 (NBCe1/Slc4a4), predominantly expressed in astrocytes, is important for brain pH regulation and homeostasis. Increased NBCe1 expression in reactive astrocytes has been associated with neuron...
Macrophage Targeting Protects Nerve Structure and Improves Muscle Innervation in a Mouse Model of Charcot-Marie-Tooth 2J [0.03%]
靶向巨噬细胞能保护神经结构并改善Charcot-Marie-Tooth 2J小鼠模型的肌肉支配
Dennis Klein,Neslim Ercan,Xidi Yuan et al.
Dennis Klein et al.
In several previous studies, we have shown that macrophage targeting with the CSF-1 receptor specific kinase (c-FMS) inhibitor PLX5622 led to a substantial alleviation of the neuropathy in distinct mouse models of demyelinating Charcot-Mari...
Reduced Accumulation Rate and Morphological Changes of Newly Generated Myelinating Oligodendrocytes in the Corpus Callosum of Aged Mice [0.03%]
小鼠脑衰老伴胼胝体髓鞘少突胶质细胞生成速率降低及形态变化
Sasikarn Looprasertkul,Reiji Yamazaki,Yasuyuki Osanai et al.
Sasikarn Looprasertkul et al.
The activity of oligodendrocyte progenitor cells (OPCs) and oligodendrocytes (OLs) throughout life drives myelination, which is crucial for rapid neuronal communication. OLs in the aging brain demonstrate a reduced capacity for myelin forma...
Lcn2-Induced Oligodendrocyte Ferroptosis Contributes to White Matter Damage in Chronic Cerebral Hypoperfusion [0.03%]
Lcn2诱导的少突胶质细胞铁死亡参与慢性脑低灌注白质损伤
Qian Liu,Jiaxin Liu,Shiqin Li et al.
Qian Liu et al.
Chronic cerebral hypoperfusion (CCH) is associated with cognitive impairment and white matter damage. Lipocalin-2 (Lcn2) has been reported to be associated with both white matter lesions and cognitive impairment. Our previous studies reveal...
Werner Dykstra,Zuzana Matusova,Rachel A Battaglia et al.
Werner Dykstra et al.
Glial fibrillary acidic protein (GFAP) is a type-3 intermediate filament protein mainly expressed in astrocytes in the central nervous system. Mutations in GFAP cause Alexander disease (AxD), a rare and fatal neurological disorder. How exac...
Acid-Sensing PAC Channel Promotes Astrocyte Acidosis in Ischemic Stroke [0.03%]
缺血性卒中时PAC酸感受通道促进星形胶质细胞酸中毒
Yifei Liu,Yun Zhang,Meng Sun et al.
Yifei Liu et al.
Astrocyte is critically involved in the central nervous system homeostasis and initiates tissue pathology in response to insults to the central nervous system. However, whether and how astrocytes sense micro-environmental changes, such as i...