Novel Roles for the Ectoenzyme CD38 in the Maintenance of Transcriptional and Metabolic Homeostasis in Astrocytes [0.03%]
CD38核苷酸酶在外星细胞转录和代谢稳态维持中的新作用
S Basak,A M Colafrancesco,R D Hernandez et al.
S Basak et al.
CD38 is an ectoenzyme that converts NAD+ to NAM to help maintain bioenergetic homeostasis. CD38 dysregulation and gene variation is reported in neurodegenerative conditions such as Parkinson's disease (PD) and Alzheimer's disease (AD), high...
Aberrant Molecular Myelin Architecture in Charcot-Marie-Tooth Disease Type 1A and Hereditary Neuropathy With Liability to Pressure Palsies [0.03%]
Charcot-Marie-Tooth病1型和遗传性压力易感周围神经病变的分子髓鞘结构异常
Kathryn R Moss,Marvis A Arowolo,Dave R Gutierrez et al.
Kathryn R Moss et al.
Charcot-Marie-Tooth Disease Type 1A (CMT1A) and Hereditary Neuropathy with Liability to Pressure Palsies (HNPP) are the most common inherited peripheral neuropathies and arise from copy number variation of the Peripheral Myelin Protein 22 (...
LRP4+ Astrocytes: A Unique Subpopulation Crucial for Blood Vessel Maintenance and Function in the Somatosensory Cortex of Normal and 5xFAD Mice [0.03%]
LRP4+星形胶质细胞：该亚群对正常和5XFAD小鼠躯体感觉皮层中血管维持与功能的独特重要性
Emily Arzola,Gefei Yu,Lei Xiong et al.
Emily Arzola et al.
Astrocytes exhibit significant heterogeneity in morphology, molecular profiles, and function. While these cells perform diverse roles, their functional specialization across distinct subgroups remains poorly characterized. Lipoprotein recep...
Sage Martineau,Juan C Valdez-Lopez,Samantha Zarnick et al.
Sage Martineau et al.
Microglia make important contributions to central nervous system (CNS) development, but the breadth of their distinct developmental functions remains poorly understood. The mouse retina has been a key model system for understanding fundamen...
Activation of Wnt3a Signaling Rescues the Analgesic Efficacy of Morphine by Regulating Microglial Reactivation in the Spinal Cord [0.03%]
Wnt3a信号通过调节脊髓小胶质细胞再激活来恢复阿片类药物的镇痛作用
Cheng Li,Hongyu Yao,Mingzheng Wu et al.
Cheng Li et al.
Repetitive opioid treatment promotes analgesic tolerance through mechanisms involving opioid-induced neuroinflammation. Here, we report that Wnt signaling activation can rescue opioid analgesic effects and suppress neuroinflammation by regu...
RetSat Knockout Mitigates Hypoxia-Induced Microglial Activation by Enhancing Lipid Droplets Degradation [0.03%]
RetSat敲除通过促进脂滴降解缓解缺氧诱导的小胶质细胞活化
Wenyu Hu,Shuoshuo Li,Wenjun Shi et al.
Wenyu Hu et al.
Exposure to hypoxic environments leads to neurological dysfunction, with recent studies implicating microglia-derived neuroinflammation involved in hypoxia-induced neuronal impairment. However, the underlying pathological mechanisms remain ...
SGK1 Inhibition Improved Mitochondrial Dysfunction and Astrocyte Senescence in Hepatic Encephalopathy via IL-6/JAK2/STAT3 Signaling Pathway [0.03%]
SGK1抑制通过IL-6/JAK2/STAT3信号通路改善肝性脑病中线粒体功能障碍和星形胶质细胞衰老
Guqing Luo,Jiwei Yu,Hongjie Li et al.
Guqing Luo et al.
Astrocyte senescence plays an essential role in CNS disorders. However, the understanding of astrocyte senescence and its regulatory targets in hepatic encephalopathy (HE) is limited. SGK1 was reported to regulate astrocyte senescence. Ther...
FGF Receptor Signaling in Oligodendrocytes Regulates Synaptic Plasticity, Learning, and Memory in the Adult Brain [0.03%]
少突胶质细胞中的FGF受体信号调节成人脑的突触可塑性、学习和记忆
M Furusho,B Das,R Yan et al.
M Furusho et al.
Oligodendrocytes (OLs) generate myelin sheaths around axons and maintain them to facilitate the propagation of action potentials and support neuronal metabolism and synaptic function. Previously, we have shown that Fibroblast Growth Factor ...
Meteorin Resolves Nociceptive Hypersensitivity by Reducing Connexin-Mediated Coupling in Satellite Glial Cells [0.03%]
气象激素通过减少卫星神经胶质细胞中的连接蛋白介导的偶联来缓解伤害性感觉过敏
Lone Tjener Pallesen,Anna-Kathrine Pedersen,Ishwarya Sankaranarayanan et al.
Lone Tjener Pallesen et al.
Neuropathic pain, a persistent condition arising from injury to the nervous system, involves complex interactions between neurons and non-neuronal cells, including satellite glial cells (SGCs) in the dorsal root ganglia (DRG). In this study...
Astrocytic TCF7L2 Impacts Brain Osmoregulation and Restricts Neuronal Excitability [0.03%]
星形胶质细胞TCF7L2影响脑部渗透压调节并限制神经元兴奋性
Mariusz Popek,Krzysztof Goryca,Dorota Adamska et al.
Mariusz Popek et al.
Astrocytes differentiate and mature during postnatal development, but the molecular mechanisms linking their maturation to neuronal function remain unclear. We investigated the role of Wnt/β-catenin signaling and its effector, the transcri...