A Dynamic Change of Microglial States Occurs During the Transition From Photoreceptor Degeneration to Regeneration in Zebrafish pde6c Mutants [0.03%]
斑马鱼视杆细胞退行性病变转为再生期间小胶质细胞状态的动态变化发生在pde6c突变体中
Darshini Ravishankar,Yuki Takeuchi,Ichiro Masai
Darshini Ravishankar
Microglia, brain-resident immune cells, maintain brain homeostasis. However, homeostatic microglia dynamically change into disease-associated microglia in human neurodegenerative diseases. Furthermore, microglia-mediated inflammation is req...
Spleen Tyrosine Kinase (SYK) is Necessary for cGAS-STING Signaling in Müller Glia and Visual Function Deficits in Diabetic Mice [0.03%]
脾酪氨酸激酶(SYK)是糖尿病小鼠Müller胶质细胞cGAS-STING信号通路和视觉功能缺陷所必需的
Esma I Yerlikaya,Siddharth Sunilkumar,Sandeep M Subrahmanian et al.
Esma I Yerlikaya et al.
It is well established that inflammation contributes to the ocular complications caused by diabetes; however, the specific molecular events that drive diabetes-induced pro-inflammatory signaling in the retina remain to be fully elucidated. ...
Post-Mortem Delay Induces Distinct Transcriptional and Morphological Changes in Microglia With Age-Specific Patterns [0.03%]
死后延迟诱导的小胶质细胞转录和形态的特定变化及年龄相关模式
Stanislav Kozlov,Eduard Schmidt,Heidi Theis et al.
Stanislav Kozlov et al.
Postmortem tissue is a vital resource for transcriptomic studies of human microglia, yet the influence of postmortem delay (PMD) on microglial states, particularly in aging, remains insufficiently understood. Here, we examined the impact of...
RXR Gamma Enables Oligodendrocyte Differentiation by Suppressing Sonic Hedgehog Signaling [0.03%]
抑制 Sonic Hedgehog 信号转导诱导少突胶质细胞分化的 RXRγ作用机制研究
Vito Antonio Baldassarro,Quentin Brassart,Valérie Fraulob et al.
Vito Antonio Baldassarro et al.
Overcoming remyelination failure is one of the main targets in therapeutic strategies for multiple sclerosis. This process requires the differentiation of oligodendrocyte precursor cells (OPCs) to mature myelinating oligodendrocytes (OLs), ...
Glia Are Bussin': How Single-Cell and Spatial Transcriptomics Enlighten the Role of Neuroglia in Spinal Cord Injury and Regeneration [0.03%]
胶质细胞很活跃：单细胞和空间转录组学如何阐明神经胶质细胞在脊髓损伤和再生中的作用
Julio Mejia,Philip J Horner
Julio Mejia
The impact that single-cell and spatial genomic technologies have had on the scientific community since their advent has been widespread and profound. The field of spinal cord injury (SCI) is one such area that has experienced an increased ...
Developmental Profiling of Structural and Functional Maturation in Mouse Corpus Callosum [0.03%]
小鼠胼胝体结构和功能成熟的发育特征分析
Hayes Johnson,Maren Beall,Sophia Latifi et al.
Hayes Johnson et al.
As the largest white matter tract within the central nervous system (CNS) to connect two cerebral hemispheres, the corpus callosum axon bundle consists of a mixture of myelinated and unmyelinated axons and plays a crucial role in executing ...
Conservation of Neuron-Astrocyte Correlated Activity in Developing Sensory Pathways [0.03%]
发育感觉通路中神经元-星形胶质细胞相关活性的保守性研究
Vered Kellner,Patrick Parker,Dongeun Heo et al.
Vered Kellner et al.
Neurons in developing sensory organs exhibit prolonged burst firing before the onset of sensory experience. This activity promotes neuronal survival and maturation in central sensory pathways. Within the auditory system, periodic bursts of ...
Microglial Inhibition Promotes Proliferation and Differentiation of Neural Stem Cells via STAT3/SDF-1/CXCR4 Signaling Pathway in Hypoxic-Ischemic Encephalopathy [0.03%]
微抑制促进STAT3/SDF-1/CXCR4信号通路在缺氧缺血性脑病中促进神经干细胞增殖及分化的作用研究
Ao Ding,Guiqin Duan,Mingwei Zhu et al.
Ao Ding et al.
Neonatal hypoxic-ischemic encephalopathy (HIE) may induce substantial neuronal damage. In particular, an overactivation of microglia following HIE represents a pathogenically important process. Previous studies have shown that microglial in...
Inflammatory Mediators Both Directly and Indirectly Promote Microglial Proliferation [0.03%]
炎症介质通过直接和间接途径促进小胶质细胞增殖
Brady P Hammond,Eugene Hahn,Kelly V Lee et al.
Brady P Hammond et al.
Microglia-the predominant immune cell of the central nervous system (CNS)-possess an astounding capacity for proliferation. In development, this proliferation ensures that microglia are present at a sufficient density to perform their vital...
Single-Nucleus Transcriptomics Reveals Microglial State Transitions and Astrocytic Trajectory Divergence During Glial Remodeling Induced by Intracortical Electrode Implantation [0.03%]
单细胞核转录组揭示了皮层电极植入诱导的胶质重构过程中小胶质细胞状态转变和星形胶质细胞轨迹分歧
Zhi Zhao,Xiaoge Duan,Hanjun Huang et al.
Zhi Zhao et al.
The foreign body response to intracortical electrodes, characterized by chronic neuroinflammation and glial scar formation, remains a primary cause of long-term functional failure. However, neurons and glial cells' heterogeneity and interce...