The discovery of antiviral agents: ten different compounds, ten different stories [0.03%]
抗病毒药物的发现——十种化合物，十个故事
Erik De Clercq
Erik De Clercq
This review article, while autobiographical to some extent, describes the discovery of ten (classes of) antiviral compounds that have made (or just did not make) it to the market for the therapy of viral infections, but each in its own way ...
Armando M De Palma,Inge Vliegen,Erik De Clercq et al.
Armando M De Palma et al.
Picornaviruses cover a large family of pathogens that have a major impact on human but also on veterinary health. Although most infections in man subside mildly or asymptomatically, picornaviruses can also be responsible for severe, potenti...
Studies on search for bioactive natural products targeting TRAIL signaling leading to tumor cell apoptosis [0.03%]
针对TRAIL信号通路诱导肿瘤细胞凋亡的抗肿瘤活性天然产物研究
Masami Ishibashi,Takashi Ohtsuki
Masami Ishibashi
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induces apoptosis in many transformed cells but not in normal cells and, hence, has been expected as a new anticancer strategy. During our studies on search for bioactive...
Chemical regulation of epigenetic modifications: opportunities for new cancer therapy [0.03%]
表观遗传修饰的化学调控：新的癌症治疗方法展望
Yujun George Zheng,Jiang Wu,Ziyue Chen et al.
Yujun George Zheng et al.
Epigenetics is concerned about heritable changes in gene expression without alteration of the coding sequence. Epigenetic modification of chromatin includes methylation of genomic DNA as well as post-translational modification of chromatin-...
Preclinical efficacy on GSK-3 inhibitors: towards a future generation of powerful drugs [0.03%]
GSK-3抑制剂的药效学前期研究：通向开发新一代强力药物之路
Ana Martinez
Ana Martinez
The renewed interest in glycogen synthase kinase-3 (GSK-3), involved in the molecular pathogenesis of human severe diseases, is focused on the potential of its inhibitors to treat diseases that have significant limitations in their current ...
Florence Teillet,Ahcene Boumendjel,Jean Boutonnat et al.
Florence Teillet et al.
Tyrosine kinase receptors (RTKs) play a crucial role in the regulation of the cell division cycle. Currently more than 50 RTKs divided into several subfamilies have been described. The inhibition of these enzymes has emerged as an important...
Recent advances in plant hepatoprotectives: a chemical and biological profile of some important leads [0.03%]
植物保肝药研究的新进展——某些重要先导化合物的化学及生物特征分析
Arvind S Negi,J K Kumar,Suaib Luqman et al.
Arvind S Negi et al.
Medicinal plants have been traditionally used for treating liver diseases since centuries. Several leads from plant sources have been found as potential hepatoprotective agents with diverse chemical structures. Although, a big list of hepat...
3D Bioprinting for Engineering Organoids and Organ-on-a-Chip: Developments and Applications [0.03%]
用于类器官和芯片器官工程的三维生物打印：进展与应用
Three-dimensional (3D) bioprinting is a promising technology for the fabrication of complex tissue structures with bionic biological functions and stable mechanical properties. Compared to traditional two-dimensional models and animal model...