Hepatotoxicity in the Era of Precision Medicine: Toxicological Mechanisms and Management of Immune and Cell Therapy-Induced Liver Injury [0.03%]
精准医疗时代的肝毒性：免疫和细胞治疗诱导的肝损伤的毒理机制与管理
Yujian Fan,Xiaokai Guo,Jiaying Lyu et al.
Yujian Fan et al.
Immune checkpoint inhibitors and adoptive cell therapies have revolutionized cancer treatment, yet their success is accompanied by immune-related hepatotoxicity that can range from asymptomatic enzyme elevation to life-threatening liver fai...
Dohee Kim,Shinwon Kang,Hyejin Jo et al.
Dohee Kim et al.
Hydrogels have been widely used in tissue engineering due to their high-water content and biocompatibility, yet their densely cross-linked microstructure inherently limits cell infiltration, mass transport, and mechanical support. Cryogels,...
Ezgi Duman,Girish Pattappa,Patrick Pann et al.
Ezgi Duman et al.
Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in...
Emerging Trends in Artificial Intelligence-Driven Drug Discovery: Balancing Chemical Design and Pharmacological Properties for Cancer Therapy [0.03%]
人工智能驱动的药物发现领域的新趋势：在化学设计和药理特性之间取得平衡以进行癌症治疗
Mohsin Ali,Muhammad Ali Tajwar,Farid Ahmed et al.
Mohsin Ali et al.
Traditional cancer drug discovery encounters challenges, including lengthy synthesis durations, high costs, and a 90% failure rate in clinical trials, primarily due to inadequate chemical design and drug properties. Artificial intelligence ...
Hsp90 Inhibition on the Western Blot: N-Terminal Versus C-Terminal Inhibitors in Breast Cancer [0.03%]
HSP90抑制在西方印迹：乳腺癌中的N-端与C-端抑制剂
Jaka Dernovšek,Jernej Cingl,Urša Pečar Fonović et al.
Jaka Dernovšek et al.
Heat shock protein 90 (Hsp90) is an established and clinically validated anticancer target. By regulating the folding and maturation of diverse client proteins, it is indirectly involved in carcinogenesis. Key breast cancer oncogenic driver...
The FGF/FGFR System in the Biology and Therapeutic Landscape of Pediatric CNS Tumors [0.03%]
FGF/FGFR系统在儿童中枢神经系统肿瘤的生物学和治疗中的作用
Serena Filiberti,Camilla Tavani,Elena Somenza et al.
Serena Filiberti et al.
Central nervous system (CNS) tumors are the most common solid malignancies in children, comprising a highly heterogeneous group of neoplasms defined by distinct molecular alterations and clinical behaviors. Advances in molecular genetics ha...
PAK4 in the Tumor Immune Microenvironment: Biological Functions, Regulatory Mechanisms, and Targeted Therapeutic Strategies [0.03%]
肿瘤免疫微环境中的PAK4：生物学功能、调控机制与靶向治疗策略
Yiming Wang,Wuxiyar Otkur,Maosheng Cheng et al.
Yiming Wang et al.
p21-activated kinase 4 (PAK4), a critical effector of Ras homologous (Rho) GTP hydrolases (GTPases), promotes tumor progression and confers resistance to therapy by regulating malignant cellular phenotypes-such as proliferation, metastasis,...
AI-Driven Multi-Omics Integrated Applications Using Diverse Neural Networks for Breast Cancer Diagnostic Screening and Biomarker Discovery [0.03%]
基于多种神经网络的乳腺癌诊断筛查与生物标志物发现的AI驱动多组学集成应用
Vandana Kumari,Harshita Tiwari,Swati Singh et al.
Vandana Kumari et al.
Breast cancer (BC) is a highly complex and heterogeneous malignancy and the most prevalent cancer among women worldwide. The diagnosis, prognosis, and the treatment of BC pose significant challenges that are responsible for their limited th...
Zhiqi Peng,Yuqi Fu,Yanmei Chen et al.
Zhiqi Peng et al.
The extracellular signal-regulated kinases 1 and 2 (ERK1/2) play central roles in the mitogen-activated protein kinase (MAPK) pathway and have emerged as critical regulators of tumorigenesis. Aberrant ERK1/2 signaling is frequently observed...
Advances in Small Molecule Research Targeting Monoacylglycerol Lipase in Drug Discovery [0.03%]
药物发现中靶向单酰基甘油脂酶的小分子研究进展
Shuming Chen,Jun Yang,Weipeng Hu et al.
Shuming Chen et al.
Monoacylglycerol lipase (MAGL), a member of the endocannabinoid system (ECS), plays a crucial role in physiological processes such as regulating the signal transduction of the ECS and the eicosanoid system. In recent years, MAGL has been va...