Artificial Intelligence-Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation [0.03%]
人工智能驱动的天然产物药物发现：从计算基因组挖掘到临床转化
Antonio Lavecchia
Antonio Lavecchia
Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotatio...
Navigating the Complexity: A Comprehensive Review of GSK-3 Inhibition in Regenerative Medicine [0.03%]
复杂性导航：再生医学中GSK-3抑制的全面回顾
Davide Schiroli,Alessia Merra,Chiara Marraccini et al.
Davide Schiroli et al.
Glycogen synthase kinase-3 (GSK-3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of ...
Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host-Directed Strategies [0.03%]
结核病药物研发进展：从小分子到宿主导向策略
Tânia Silva,Alessandra Aiello,Tonino Alonzi et al.
Tânia Silva et al.
The global burden of multidrug-resistant tuberculosis (MDR-TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxi...
Hepatotoxicity in the Era of Precision Medicine: Toxicological Mechanisms and Management of Immune and Cell Therapy-Induced Liver Injury [0.03%]
精准医疗时代的肝毒性：免疫和细胞治疗诱导的肝损伤的毒理机制与管理
Yujian Fan,Xiaokai Guo,Jiaying Lyu et al.
Yujian Fan et al.
Immune checkpoint inhibitors and adoptive cell therapies have revolutionized cancer treatment, yet their success is accompanied by immune-related hepatotoxicity that can range from asymptomatic enzyme elevation to life-threatening liver fai...
Dohee Kim,Shinwon Kang,Hyejin Jo et al.
Dohee Kim et al.
Hydrogels have been widely used in tissue engineering due to their high-water content and biocompatibility, yet their densely cross-linked microstructure inherently limits cell infiltration, mass transport, and mechanical support. Cryogels,...
Ezgi Duman,Girish Pattappa,Patrick Pann et al.
Ezgi Duman et al.
Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in...
Emerging Trends in Artificial Intelligence-Driven Drug Discovery: Balancing Chemical Design and Pharmacological Properties for Cancer Therapy [0.03%]
人工智能驱动的药物发现领域的新趋势：在化学设计和药理特性之间取得平衡以进行癌症治疗
Mohsin Ali,Muhammad Ali Tajwar,Farid Ahmed et al.
Mohsin Ali et al.
Traditional cancer drug discovery encounters challenges, including lengthy synthesis durations, high costs, and a 90% failure rate in clinical trials, primarily due to inadequate chemical design and drug properties. Artificial intelligence ...
Hsp90 Inhibition on the Western Blot: N-Terminal Versus C-Terminal Inhibitors in Breast Cancer [0.03%]
HSP90抑制在西方印迹：乳腺癌中的N-端与C-端抑制剂
Jaka Dernovšek,Jernej Cingl,Urša Pečar Fonović et al.
Jaka Dernovšek et al.
Heat shock protein 90 (Hsp90) is an established and clinically validated anticancer target. By regulating the folding and maturation of diverse client proteins, it is indirectly involved in carcinogenesis. Key breast cancer oncogenic driver...
The FGF/FGFR System in the Biology and Therapeutic Landscape of Pediatric CNS Tumors [0.03%]
FGF/FGFR系统在儿童中枢神经系统肿瘤的生物学和治疗中的作用
Serena Filiberti,Camilla Tavani,Elena Somenza et al.
Serena Filiberti et al.
Central nervous system (CNS) tumors are the most common solid malignancies in children, comprising a highly heterogeneous group of neoplasms defined by distinct molecular alterations and clinical behaviors. Advances in molecular genetics ha...
PAK4 in the Tumor Immune Microenvironment: Biological Functions, Regulatory Mechanisms, and Targeted Therapeutic Strategies [0.03%]
肿瘤免疫微环境中的PAK4：生物学功能、调控机制与靶向治疗策略
Yiming Wang,Wuxiyar Otkur,Maosheng Cheng et al.
Yiming Wang et al.
p21-activated kinase 4 (PAK4), a critical effector of Ras homologous (Rho) GTP hydrolases (GTPases), promotes tumor progression and confers resistance to therapy by regulating malignant cellular phenotypes-such as proliferation, metastasis,...