Near-Infrared Fluorescent Probe for the Early Diagnosis of Alzheimer's Disease [0.03%]
用于阿尔茨海默病早期诊断的近红外荧光探针
Yan Liu,Yuning Sun,Pei Zhao et al.
Yan Liu et al.
Alzheimer's disease (AD) is a common progressive neurodegenerative disease characterized by abnormal deposition of amyloid-β protein (Aβ) and the formation of neurofibrillary tangles (NFT). Although there are drugs available for clinical ...
The Discovery of Cryptic Pockets Increases the Druggability of "Undruggable" Proteins [0.03%]
神秘口袋的发现增加了对“不可成药”蛋白质成药的可能性
Minyue Mou,Weicheng Yang,Guangyi Huang et al.
Minyue Mou et al.
The absence of suitable biological targets is one of the most formidable obstacles to drug development. The investigation of "undruggable" proteins has the potential to significantly increase the druggable proteome. Cryptic pockets represen...
A Focus on Natural Autophagy Modulators as Potential Host-Directed Weapons Against Emerging and Re-Emerging Viruses [0.03%]
聚焦天然自噬调节剂作为对抗新发和再现病毒的潜在宿主导向型武器
Ilaria Cursaro,Sara Rossi,Stefania Butini et al.
Ilaria Cursaro et al.
Autophagy is a highly conserved intracellular process involved in maintaining homeostasis and in the degradation of damaged organelles and external pathogens. Nature provides complex and varied reservoirs of scaffolds and chemical entities ...
Comprehensive Insights Into Sulfanilamido-Based Medicinal Design and Research [0.03%]
基于磺胺酰胺药物设计和研发的全面见解
Yi-Xin Wang,Juan Wang,Lin-Li Mou et al.
Yi-Xin Wang et al.
The sulfanilamido skeleton is the core part of many clinical drugs with the para-aminobenzenesulfamido scaffold. Especially as the first type of synthetic antibacterial drugs, sulfanilamides have played important roles in preventing and tre...
Ferdinand Ndikuryayo,Xue-Yan Gong,Ge-Fei Hao et al.
Ferdinand Ndikuryayo et al.
The increasing prevalence of drug resistance (DR) and pesticide resistance poses a significant threat to public health, necessitating the development of innovative strategies to discover more effective drugs and pesticides. In this context,...
Progress in Molecular Imprinting-From Inhibition of Enzymatic Activity to Regulation of Cellular Pathways [0.03%]
分子印迹进展：从抑制酶活性到调节细胞通路
Milada Vodova,Jaroslava Bezdekova,Marketa Vaculovicova
Milada Vodova
Molecular imprinting is a very powerful tool in life science. The research areas benefiting from a wide range of capabilities of molecularly imprinted polymeric nanoparticles (nanoMIPs) include sample preparation, extraction, sensing/detect...
Decoding Gene Expression Changes in Cerebral Tumors: Before and After Radiotherapy [0.03%]
放射治疗前后来胶质瘤中的基因表达变化解析
Ahana Maitra,Morena Miciaccia,Manuela Mandorino et al.
Ahana Maitra et al.
Cerebral tumors, particularly in pediatric patients, pose a significant challenge in oncology. Radiotherapy is a crucial component of the multimodal treatment approach for these tumors. Understanding the molecular basis of these tumors, par...
Xin Zhou,Lupei Du,Minyong Li
Xin Zhou
As the most extensively studied photoswitch in photopharmacology, the azobenzene photoswitch has precision instrumental in the photoregulation of physiological processes across various animal models. Currently, it exhibits the greatest clin...
Therapeutic Potential of Vascular Adhesion Protein-1 (VAP-1)/Semicarbazide-Sensitive Amine Oxidase (SSAO) Inhibitors: Current Medicinal Chemistry and Emerging Opportunities [0.03%]
黏附血管蛋白-1（VAP-1）/半卡巴腙敏感胺氧化酶（SSAO）抑制剂的治疗潜力：药物化学现状及新兴机遇
Pinaki Bhattacharjee,Malliga R Iyer
Pinaki Bhattacharjee
Semicarbazide-sensitive amine oxidase (SSAO) is a vascular enzyme and expressed in high concentrations in vascular smooth muscle cells (VSMCs), localized in the caveolae of the plasma membrane, and the endothelial cells. SSAO is classified ...
Targeting Histone H3K9 Methyltransferase G9a as a Potential Therapeutic Strategy for Neuropsychiatric Disorders [0.03%]
靶向组蛋白H3K9甲基转移酶G9a作为神经精神疾病潜在的治疗策略
Malak Hajar,Tobias Werner,Mihajlo Gajic et al.
Malak Hajar et al.
Neuropsychiatric disorders present a multifaceted challenge, characterized by cognitive, social, and motor impairments with manifold underlying mechanisms. Recent attention has turned to epigenetic mechanisms, particularly histone lysine me...