Targeting PDGFR, EGFR, FGFR, and VEGFR: Key Receptor Tyrosine Kinases-Driven Metabolic Reprogramming in Pulmonary Arterial Hypertension [0.03%]
靶向PDGFR、EGFR、FGFR和VEGFR：肺动脉高压关键受体酪氨酸激酶驱动的代谢重组
Yanfei Mo,Desheng Wang,Yang Bai
Yanfei Mo
Pulmonary arterial hypertension (PAH) is a rare and life-threatening pulmonary vascular disease distinguished by vasoconstriction and remodeling of the pulmonary artery, leading to sustained elevated pulmonary artery pressure, right ventric...
Exploring Autophagy Inducing Molecules: Targeting Diverse Pathways in Alzheimer's Disease Management [0.03%]
自噬诱导分子在阿尔茨海默病管理中的作用：靶向不同途径
Baljinder Singh,Shubham Mahajan,Sadikalmahdi Abdella et al.
Baljinder Singh et al.
Neurodegenerative disorders, including Alzheimer's disease (AD), impose a significant burden on society due to their progressive nature and the associated healthcare costs. Autophagy, a vital cellular degradation process, has emerged as a p...
Navigating Solute Carrier Transporters-A Comprehensive Review of Functionalized Small Molecule Probes for Target Identification and Characterization [0.03%]
化学生物学导向药物发现：溶质载体转运蛋白的功能化小分子探针靶点识别及表征综述
Majlen A Dilweg,Tracie Widjaja,Adriaan P IJzerman et al.
Majlen A Dilweg et al.
Solute carrier transporters (SLCs) are integral membrane proteins that play pivotal roles in maintaining cellular homeostasis by mediating the transport of a diverse range of substrates across cell membranes. With their involvement in funda...
Astatine-211-Towards In Vivo Stable Astatine-211 Labeled Radiopharmaceuticals and Their (Pre)Clinical Applications [0.03%]
放射性药物中的砹-211及其在体内的应用和临床前研究
Marius Müller,Nadia Bom Pedersen,Vladimir Shalgunov et al.
Marius Müller et al.
Targeted radioligand therapy has emerged as a promising treatment option for eradicating advanced cancer forms. α-Emitters are considered particularly promising as they can obliterate (micro)-metastases. The α-emitter astatine-211 (211At)...
Yuting Xin,Fangsu Chen,Qidong You et al.
Yuting Xin et al.
The burgeoning field of CBMs represents a significant stride in the evolution of targeted therapeutics. This class of compounds, characterized by their ability to form stable covalent bonds with specific proteins of interest (POIs) or biolo...
Modulators of Diacylglycerol Kinase Activity: A Review of Advances and Challenges [0.03%]
关于二酰基甘油激酶活性调节剂的研究进展与挑战综述
Luisa Racca,Gianluca Baldanzi,Alberto Massarotti
Luisa Racca
Catalyzing the conversion of diacylglycerol (DAG) in phosphatidic acid (PA), diacylglycerol kinases (DGKs) play a pivotal role in all the physiological processes modulated by these two bioactive lipids, such as lipid metabolism and immune r...
Digital Therapeutics for Alzheimer's and Parkinson's Diseases: Current Trends and Future Perspectives [0.03%]
数字治疗在阿尔茨海默病和帕金森病中的应用：现状与未来展望
Yoo Joo Jeong,Hyun-Ju Lee,Jun-Su Kim et al.
Yoo Joo Jeong et al.
Alzheimer's disease (AD) and Parkinson's disease (PD), which are characterized by the accumulation of misfolded protein aggregates and cognitive/motor dysfunction, are the most prevalent neurodegenerative diseases (NDDs). Despite strategic ...
Structural Properties, Pathophysiological Relevance and Synthetic Modulators of TRPC Channels [0.03%]
瞬时受体电位通道C（TRPC）的结构特性、病理生理意义及其合成调控剂
Xue Qiao,Chunlin Ren,Wumei Wang et al.
Xue Qiao et al.
Transient receptor potential canonical (TRPC) channels, a subfamily of calcium-permeable cation channels, regulate diverse physiological processes and are implicated in disorders including neurological conditions, cardiovascular diseases, a...
Advances in Nanotechnology-Enabled Optical Biosensors for Dengue Virus Detection: A Systematic Review [0.03%]
纳米技术使能的登革病毒检测光学生物传感器进展：系统性综述
Marta Quero-Delgado,Helena Codina,Rafael Gómez et al.
Marta Quero-Delgado et al.
The dramatic surge in dengue cases in early 2024, endangering half the global population, urgently necessitates faster diagnostic methods. Nanotechnology-enabled optical biosensors offer a promising avenue, leveraging nanomaterial propertie...
Le Wang,Tao Zhang,Na Wang et al.
Le Wang et al.
The monkeypox (mpox) outbreak has once again become a Public Health Emergency of International Concern, increasing the focus of research on the development of anti-monkeypox drugs. Monkeypox virus (MPXV) is a member of the Orthopxviridae ge...