Kinin B1 and B2 Receptors: Role in Tumor Progression and Pain Associated With Tumor and Anticancer Therapy [0.03%]
激肽B1和B2受体在肿瘤进展及与肿瘤相关的疼痛和抗癌症治疗中的作用
Indiara Brusco,Sara Marchesan Oliveira
Indiara Brusco
Cancer is the second leading cause of death globally, with an estimated worldwide incidence of 19.3 million cases in 2020, and is expected to increase by 47% in the next 20 years. Painful symptoms of tumors and anticancer treatment negative...
The Evolution of Benzodiazepine Allosteric Modulators: Structural Insights From Historical Milestones to Emerging Innovations in Drug Discovery and Development [0.03%]
苯二氮卓类变构调节剂的演变：从历史里程碑到药物发现和开发新兴创新的结构见解
Hongyu Jiang,Zhipeng Hu,Lixin Yang et al.
Hongyu Jiang et al.
Benzodiazepine drugs (BZDs) have been central to neuropsychopharmacology since the 1960s, acting as positive allosteric modulators of γ-aminobutyric acid type A (GABAA) receptors to enhance inhibitory neurotransmission. Despite their clini...
Design and Development of Small-Molecule Drugs Targeting Enzymes Utilizing Two-Metal-Ion Catalytic Mechanisms [0.03%]
利用双金属离子催化机制的酶的小分子药物的设计与开发
Chenzhong Liao,Xuezhi Zhao,Qin Wang
Chenzhong Liao
The active sites of numerous metalloproteins feature two metal ion cofactors-either identical or distinct-that are positioned in close proximity, typically around 3.8 Å apart. This two-metal-ion catalytic mechanism (TCM) endows these enzym...
Pharmacological Potential of Jellyfish Bioactive Peptides: From Neurodegenerative Disorders to Cancers [0.03%]
水母生物活性肽的药理潜力：从神经退行性疾病到癌症
Yining Lei,Jiaming Zhang,Gaochi Xu et al.
Yining Lei et al.
Jellyfish are vital components of marine ecosystems and significantly impact human life and industry. Globally, jellyfish populations are increasing annually, but their applications are currently limited primarily to food processing. Jellyf...
Katarina Jurkova,Hana Navratilova,Kamil Musilek et al.
Katarina Jurkova et al.
Cyclophilins are a family of enzymes with peptidyl-prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Conseq...
Light-Based Molecular Tools to Precisely Monitor and Operate β-Adrenoceptors [0.03%]
基于光的分子工具精确监测和操作β-肾上腺素受体
Ignazzitto Maria Tindara,Gómez-Santacana Xavier,Llebaria Amadeu et al.
Ignazzitto Maria Tindara et al.
β-Adrenoceptors are important G protein-coupled receptors involved in cardiovascular, metabolic, and neurological regulation. To study their function with high precision, light-based molecular tools have been developed offering precise spa...
Arginine Competition in Tumor Microenvironment: A Potential Target for Cancer Therapy [0.03%]
肿瘤微环境中鸟氨酸的竞争：癌症治疗的潜在靶点
Junlei Zhang,Sijie Wang,Huihui Liu et al.
Junlei Zhang et al.
Arginine is critical in biosynthesis, energy generation, cell proliferation, and immune regulation. In the tumor microenvironment (TME), due to limited supply and high consumption, the competition for arginine is extremely fierce. It always...
The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches [0.03%]
胆固醇和鲨烯合酶在癌症中的作用：分子机制、脂筏和治疗策略
Danai Mavridi,Theodora Katavati,Angeliki P Kourounakis
Danai Mavridi
A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the forma...
HMGB1: From Molecular Functions to Clinical Applications in Cancer and Inflammatory Diseases [0.03%]
从分子功能到临床应用——HMGB1在癌症和炎症性疾病中的作用
Linghong Guo,Daihan Wang,Xian Jiang et al.
Linghong Guo et al.
High Mobility Group Box 1 (HMGB1) is a nuclear protein crucial for nucleosome stability, gene regulation, DNA repair, cell differentiation, and development. Extracellularly, HMGB1 functions as a cytokine, significantly impacting inflammatio...
Unveiling the Function of Antimicrobial Peptides in Relation to Source and Structure [0.03%]
抗微生物肽的功能及其与来源和结构的关系
Kun Zhang,Da Teng,Ruoyu Mao et al.
Kun Zhang et al.
Antimicrobial peptides (AMPs), essential components of the body's innate defense system, are expected to exert and enhance their potential antimicrobials, immunomodation and other bio-activities that combine with traditional antimicrobial a...