Smart Integration of Structural Biology and Medicinal Chemistry to Unlock Target-Driven Drug Discovery [0.03%]
智能整合结构生物学和药物化学以解锁目标导向的药物发现
Matteo Rossi Sebastiano,Giulia Apprato,Serena Francisco et al.
Matteo Rossi Sebastiano et al.
To enhance drug discovery efforts, medicinal chemists should evaluate, filter, and utilize relevant structural information about target proteins. Acquiring and interpreting protein structures is crucial for elucidating ligand-receptor inter...
Immunosuppressive Tumor Microenvironment and Therapeutic Landscape of Diffuse Intrinsic Pontine Glioma [0.03%]
弥漫性内生脑桥胶质瘤的免疫抑制性肿瘤微环境及治疗现状
Shuyi Zhou,Sandro Matosevic
Shuyi Zhou
Diffuse intrinsic pontine glioma (DIPG) is a highly aggressive and fatal pediatric brainstem tumor, characterized by rapid progression and extremely poor prognosis. Its infiltrative growth within the pons, combined with the critical functio...
Accelerating Small Molecule Ferroptosis Regulator Development With Advances in Biological Functions [0.03%]
利用生物功能的最新进展加速小分子铁死亡调节剂的研发
Linyue Bai,Liang Shen,Qianqian Zhang et al.
Linyue Bai et al.
Ferroptosis is an iron-dependent cell death characterized by the disorder of iron homeostasis and the accumulation of lipid peroxidation, which trigger a cascade of events resulting in cell death. This process has a dual regulatory effect i...
Unlocking Multiscale Allosteric Mechanisms: Advanced Computational Strategies for Drug Discovery [0.03%]
解锁多尺度别构机制：药物发现的先进计算策略
Ruidi Zhu,Chengwei Wu,Mingyu Li et al.
Ruidi Zhu et al.
Multiscale allosteric mechanisms refer to regulatory processes in proteins that involve coordinated conformational changes and signal transmission occurring across multiple spatial and temporal scales. Exploiting these mechanisms provides p...
A Comprehensive Review of Marketed KRAS Inhibitors and Degraders: Challenges and Opportunities [0.03%]
上市KRAS抑制剂和降解剂的研究进展、机遇与挑战
Yi-Xin Xu,Yi-Ru Bai,Ruifang Li et al.
Yi-Xin Xu et al.
The rat sarcoma virus oncogene (RAS) is one of the most frequently mutated drivers in human cancers. Developing targeted therapies against RAS has been challenging due to its structure. The recent breakthroughs with covalent Kirsten RAS (KR...
The Potential, Challenges and New Horizons of Marine Natural Products Against Tuberculosis Infection [0.03%]
海洋天然产物抗结核感染的潜力、挑战及新机遇
Qun Zhang,Yi-Qian Han,Wei-Feng Xu et al.
Qun Zhang et al.
Tuberculosis (TB) is one of the most significant health perils that has claimed more lives than any other contagious disease over the past 2000 years. The treatment of tuberculosis has been severely compromised due to drug-resistant strains...
Medicinal Chemistry Strategies for the Development of CD73 Inhibitors in Cancer Immunotherapy [0.03%]
癌症免疫治疗中CD73抑制剂开发的药物化学策略
Meng Cui,Shaowei Ma,Zhe Huang et al.
Meng Cui et al.
CD73, a membrane-bound ecto-5'-nucleotidase, catalyzes the extracellular conversion of adenosine monophosphate into immunosuppressive adenosine. Functioning as an emerging immune checkpoint, CD73 is frequently upregulated across numerous tu...
FDA-Approved Pyrimidine-Containing Drugs: Synthesis and Clinical Application [0.03%]
美国食品药品监督管理局批准的嘧啶类药物：合成与临床应用
Yao Zhang,Xiaomei Liu,Chong Zhang et al.
Yao Zhang et al.
Since 2013, a rapidly expanding portfolio of U.S. Food and Drug Administration (FDA)-approved drugs has highlighted pyrimidine as one of the most versatile and therapeutically valuable heteroaromatic scaffolds. Building on more than six dec...
Respiratory Syncytial Virus (RSV): A Comprehensive Overview From Basic Biology to Clinical Prevention and Control [0.03%]
呼吸道合胞病毒(RSV)：从基础生物学、临床防治到控制的全面综述
Jie Shi,Xiya Huang,Chunjun Ye et al.
Jie Shi et al.
Respiratory syncytial virus (RSV) is a common virus that causes respiratory infections, posing a serious threat, particularly to infants, the elderly, and individuals with compromised immune systems. As the leading cause of lower respirator...
The IL-23/IL-17/NF-κB Signaling Pathway in Rheumatoid Arthritis: Molecular Mechanisms and Therapeutic Agents [0.03%]
类风湿关节炎中IL-23/IL-17/NF-κB信号通路的分子机制及治疗药物
Jiayi Deng,Yasi Deng,Yuxin Chen et al.
Jiayi Deng et al.
Rheumatoid arthritis (RA) is an autoimmune disease characterized by inflammation of the joint synovium, which can lead to bone destruction. Prolonged inadequate treatment can result in joint disability and an increased risk of mortality. Cu...