Mucin O-Glycosylation and Mucolytic Therapies in Pseudomyxoma Peritonei: Literature Review [0.03%]
黏蛋白O-岩藻糖基化和解聚疗法在腹膜假性黏液瘤中的作用：文献回顾
Qi-Di Zhao,David L Morris,Zheng-Long Sun et al.
Qi-Di Zhao et al.
Effective mucolytic therapy can greatly improve the efficacy of cytoreductive surgery + hyperthermic intraperitoneal chemotherapy, alleviate symptoms and improve prognosis for pseudomyxoma peritonei (PMP) patients. The main components of PM...
Urologic Bacteriome: The Hero or the Villain in Prostate Cancer Onset, Progression, and Treatment? [0.03%]
泌尿系统细菌组：在前列腺癌的发生、发展和治疗中是英雄还是罪犯？
Lara R S Fonseca,Mariana Feijó,Cátia V Vaz et al.
Lara R S Fonseca et al.
Prostate cancer (PCa) is the second most frequently diagnosed cancer in men worldwide and the fifth leading cause of cancer-related mortality, presenting urgent unmet clinical needs in diagnosis and treatment. The recognition of the microbi...
Comparative Pharmacology of Caspase-1 Inhibitors: Ac-YVAD-CMK, Z-YVAD-FMK, and Ac-YVAD-CHO in Multisystem Diseases [0.03%]
几种 caspase-1 抑制剂在多系统疾病中的药理学比较：Ac-YVAD-CMK、Z-YVAD-FMK 和 Ac-YVAD-CHO
Yujia Zheng,Baolei Dou,Yifan Ren et al.
Yujia Zheng et al.
Cysteine-aspartic protease-1 (Caspase-1), the terminal effector of canonical inflammasome signaling, represents a validated yet pharmacologically underexploited target at the convergence of inflammatory pathology and pyroptotic cell death. ...
Beyond Antiviral Therapy: Untapped Potential of HIV & HCV Protease Inhibitors [0.03%]
超越抗病毒治疗：HIV和HCV蛋白酶抑制剂的未开发潜力
Dmitrii A Iuzabchuk,Anastasia A Andrianova,Ilia V Yampolsky et al.
Dmitrii A Iuzabchuk et al.
Development of de novo therapeutic agents is a complex, costly, and a high-risk process, whereas repurposing approved and investigational drugs for novel targets offers a more efficient and cost-effective strategy, likely yielding higher su...
Unravelling Structure-Based Molecular Activation and Antagonism of Protease-Activated Receptors for Drug Design [0.03%]
基于结构的丝氨酸蛋白酶激活受体分子活化与抑制机制及药物设计研究
Zhikang Xu,Rui Li,Jian Zhang
Zhikang Xu
Protease-activated receptors (PARs) are G protein-coupled receptors (GPCRs) characterized by their self-activation following cleavage by specific proteases, serving as vital therapeutic targets for cardiovascular and inflammatory diseases. ...
Tirzepatide in Metabolic Diseases: Clinical Efficacy and Safety Beyond Diabetes and Obesity [0.03%]
tirzepatide在代谢性疾病中的临床疗效和安全性研究——糖尿病和肥胖症以外的视角
Shixuan Dong,Ying Xu,Ran Gan et al.
Shixuan Dong et al.
Tirzepatide, a novel dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist, has attracted substantial attention for its exceptional efficacy in managing type 2 diabetes and obesity. Eme...
Aldo-Keto Reductase Family 1 Member B10 as a Therapeutic Frontier: Advances in Inhibitor Design and Multimodal Approaches [0.03%]
醛酮还原酶家族1成员B10作为治疗靶点的研究进展：抑制剂设计及多模态研究方法的发展
Jikuan Shao,Xiaolong Wang,Can Guo et al.
Jikuan Shao et al.
Aldo-keto reductase 1B10 (AKR1B10), a key member of the aldehyde-ketone reductase superfamily, plays crucial roles in tumorigenesis, chemotherapy resistance, and metabolic regulation. However, the clinical translation of its inhibitors has ...
CRISPR-Cas9 Genome-Wide Screening in Paediatric Cancer: Functional Genomics for Target Discovery and the Improvement of Existing Therapies [0.03%]
儿童癌症的CRISPR-Cas9全基因组筛选：功能基因组学在靶点发现和改进现有疗法方面的应用
Steven He,Patrick Connerty,Antoine de Weck
Steven He
CRISPR-Cas9 genome-wide screening has been instrumental towards identifying novel targets for drug discovery in cancer research. However, much of this research has centred specifically on adult cancers, with paediatric cancers being underse...
Biodegradable Natural Polymer-Based Drug Delivery Systems for Bone Tissue Engineering [0.03%]
用于骨组织工程的基于可降解天然高分子材料的药物控释体系研究进展
Hyejin Jo,Shinwon Kang,Jae Eun Yang et al.
Hyejin Jo et al.
The increasing incidence of bone diseases and injuries, especially among aging populations, has underscored the shortcomings of traditional treatments such as bone grafts and metal implants, which often face complications including immune r...
Recent Advances of Non-Nucleoside Polymerase Inhibitors With Broad-Spectrum Antiviral Activities [0.03%]
广谱抗病毒活性的非核苷类聚合酶抑制剂研究进展
Sining Tao,Zhenzhen Zhou,Xin Li et al.
Sining Tao et al.
A tremendous and painful price has been paid in the fight against pandemic viruses in the global health field. Emerging and re-emerging viruses serve as primary drivers of severe pandemics, such as influenza virus (IV), respiratory syncytia...