A Possibility of Synthetic Lethality: Wee1 Kinase as a Promising Treating Target for Cancer [0.03%]
合成致死的可能情况——Wee1激酶作为癌症治疗靶点的前景
Xin Xue,Xiao Chen,Yitian Jiang et al.
Xin Xue et al.
Wee kinases, including Wee1, Myt1 (PKMYT1) and Wee2, serve as critical regulators of the DNA damage response by inhibiting the G2/M transition and have attracted increasing attention as a targetable vulnerability in TP53-deficient cancers. ...
Insights From Spatiality: Accelerating Pharmaceutical Research Using Mass Spectrometry Imaging [0.03%]
基于空间定位的成像质谱技术助力药物研发
Yuchen Zou,Zhiye Yan,Weiwei Tang et al.
Yuchen Zou et al.
Mass spectrometry imaging (MSI) has emerged as a transformative technology in pharmaceutical research, offering unprecedented capabilities to visualize drug distribution, metabolism, and target engagement in biological tissues. By combining...
Targeting ClpP Protease: Emerging Therapeutic Strategies and Small-Molecule Modulators in Drug Discovery [0.03%]
靶向ClpP蛋白酶：药物发现中的新疗法和小分子调节剂
Lihua Liu,Minghui Yu,Xinnan Li et al.
Lihua Liu et al.
The caseinolytic protease P (ClpP) is a conserved serine protease that functions with ATPases associated with diverse cellular activities (AAA+) chaperones to ensure protein quality control in organisms ranging from bacteria to human mitoch...
Quantification of 10B and 11B in Biological Samples in Translational Science and Clinical Applications for Boron Neutron Capture Therapy (BNCT) [0.03%]
硼中子俘获治疗(BNCT)转化科学及临床应用中生物样本10B和11B的定量研究
Christoph Selg,Wolfgang A G Sauerwein,Evamarie Hey-Hawkins
Christoph Selg
Boron neutron capture therapy (BNCT) is a targeted radiotherapy that exploits the selective accumulation of the 10B isotope within tumors, followed by irradiation with low-energy neutrons to induce high linear energy transfer particles with...
STING: An Attractive Target for Autoimmune and Inflammatory Diseases [0.03%]
STING：自身免疫病和炎症性疾病的诱人治疗靶点
Zhenjiao Yang,Xinqiao Liu,Jinhong Zhan et al.
Zhenjiao Yang et al.
Stimulator of Interferon Genes (STING) is a transmembrane homodimer protein located in the endoplasmic reticulum membrane and plays an essential role in human innate immunity. Hyperactivation of STING has been found in many autoimmune and i...
Decoding WDR5-Mediated Interactions in Gliomas: Implications for Targeted Therapy [0.03%]
解码胶质瘤中的WDR5介导的相互作用及其靶向治疗意义
Edmund Jung,Christina Piperi
Edmund Jung
Gliomas are aggressive and treatment-resistant tumors of the central nervous system, characterized by molecular heterogeneity, diffuse infiltration, rapid progression, and persistent poor prognosis despite multimodal therapy. Emerging evide...
Designing the Next Generation of Antibiotics: Structure, SAR, and Strategy in Medicinal Chemistry (2000-2025) [0.03%]
下一代抗生素的设计：2000-2025药物化学中的结构、构效关系及策略
Ahmed A Al-Karmalawy,Abdullah Al-Dakhil,Nada A Ashour et al.
Ahmed A Al-Karmalawy et al.
Antibacterial agents remain vital for managing infectious diseases, yet the global escalation of antimicrobial resistance (AMR) continues to compromise their therapeutic effectiveness. Despite decades of discovery and chemical refinement, m...
Histone Deacetylase Meets Protein Degradation: Accelerating Anticancer Drug Discovery [0.03%]
组蛋白去乙酰化酶与蛋白质降解相遇：推动抗癌药物发现加速前进
Jun-Jie Wang,Ya Gao,Xin-Qian Ji et al.
Jun-Jie Wang et al.
Histone deacetylases (HDACs) are key epigenetic regulators involved in a variety of cancers, rendering them attractive therapeutic targets. Although several HDAC inhibitors have achieved clinical success, challenges such as poor isoform sel...
Advances in SIRT2-Targeted Therapeutics: Structural Insights, Chemical Strategies, and Degrader Technologies [0.03%]
SIRT2靶向治疗研究进展：结构洞察、化学策略及降解技术
Ahmed A Al-Karmalawy,Wolfgang Sippl,Abdullah Al-Dakhil et al.
Ahmed A Al-Karmalawy et al.
Sirtuin 2 (SIRT2) is an NAD⁺-dependent lysine deacylase that is a member of the sirtuin enzyme family and plays essential roles in cytoskeletal regulation, chromatin remodeling, metabolic control, inflammation, neurodegeneration, and cance...
Multi-Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns [0.03%]
针对阿尔茨海默病的多靶点配体治疗药物的研究：机制见解，新兴目标及药物发现行动
Amandeep Thakur,Mandeep Rana,Sakshi Vanjani et al.
Amandeep Thakur et al.
Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, i...