Irene Castellino,Manuela Bartolini,Rudolf Andrys et al.
Irene Castellino et al.
The circadian clock mechanism generates 24-h rhythms crucial for regulating various physiological processes, and its dysregulation has been implicated in numerous diseases. In cells, the circadian clock operates through a transcriptional-tr...
Susana Santos Braga,Nádia E Santos,Maria Almeida-Santos et al.
Susana Santos Braga et al.
The present review describes the current knowledge on phosphonates designed for brain disease therapeutics, a less explored aspect of the studies on their medicinal chemistry. Because of their structural similarity with phosphates and of th...
A Comprehensive Insight of Mechanisms of Drugs Targeting Ion Channels: Exemplified by Marine Natural Products and Their Analogues [0.03%]
海洋天然产物及其衍生物靶向离子通道药物的作用机制研究进展
Dashuai Zhang,Shugeng Cao,Shan He et al.
Dashuai Zhang et al.
Ion channels represent a significant class of drug targets implicated in the development of various diseases. In recent years, there has been a significant increase in research on the structure and function of ion channels, thereby promotin...
Molecular Pharmacology of T-Type Calcium Channels and Their Roles in Neurological Disorders [0.03%]
分子药理学中T型钙通道与神经系统疾病中的作用
Muhammad Umair,Laurent Ferron,Raja Hussain Ali et al.
Muhammad Umair et al.
Voltage-gated ion channels play important physiological roles by regulating the electrical activity of a range of different cell types through maintaining the gradients of different ions. Among these, voltage-gated calcium channels mediate ...
Selective Targeting of STAT6: Recent Advances and Future Perspectives [0.03%]
选择性靶向STAT6： recent advances和未来展望
Hua Liu,Feihai Ma,Zexu Wang et al.
Hua Liu et al.
Signal transducer and activator of transcription 6 (STAT6) is a key transcription factor in cytokine signaling, serving as the central effector of the IL-4 and IL-13 pathways. STAT6 orchestrates a range of physiological and pathological pro...
Targeting P2Y14 Receptor in Inflammatory and Metabolic Diseases: From Pathophysiology to Therapeutic Inhibitors [0.03%]
靶向P2Y14受体在炎症和代谢性疾病中的作用：从病理生理学到治疗抑制剂
Shufan Ren,Kai Wang,Jialiang Wang et al.
Shufan Ren et al.
The P2Y14 receptor (P2Y14R) is a G protein-coupled receptor (GPCR) that can be activated by the extracellular nucleotide uridine diphosphate glucose (UDPG). It performs crucial regulatory roles in diverse pathophysiological contexts, such a...
Plasmepsins as Antimalarial Drug Targets-Then, Now, and the Future [0.03%]
抗疟药物靶标血红素氧化还原酶-葡萄糖醉化酶家族蛋白的过去、现在和未来
Brad E Sleebs
Brad E Sleebs
Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D-like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite'...
Wisam A Dawood,Jacinta R Macdonald,Christian Anzenhofer et al.
Wisam A Dawood et al.
Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria-associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub-S...
Synthesis and Clinical Application of Small-Molecule Drugs Approved by FDA in 2025 [0.03%]
2025年FDA批准的小分子药物的合成与临床应用
Liang Chang,Min Wang,Huijie Zhang et al.
Liang Chang et al.
In 2025, the U.S. Food and Drug Administration (FDA) continued to advance therapeutic innovation by approving a diverse range of novel drugs. According to the FDA's 2025 Novel Drug Approvals list, 46 new drugs received approval, including b...
Exercise-Induced Exerkines: Multi-Nodal Suppression of the NLRP3 Inflammasome and Translational Potential [0.03%]
运动诱导的运动力因子：多节点抑制NLRP3炎性小体及转化潜力
Huaiming Wang,Zongqiang Jin,Shijing Di et al.
Huaiming Wang et al.
Chronic low-grade inflammation driven by persistent NLRP3 inflammasome activation is a unifying pathophysiological feature of most non-communicable diseases (NCDs). Whereas single-target pharmacological inhibitors exhibit limited breadth an...