Advances in Traditional Chinese Medicine for Diabetic Glaucoma: A Systematic Review From Holistic Pathogenesis to Multi-Target Interventions [0.03%]
糖尿病性青光眼的中医药研究进展：从整体病机到多靶标干预系统的述评
Jinshen Liu,Yujia Yu,Chen Hu et al.
Jinshen Liu et al.
Diabetic glaucoma, a severe microvascular and neurodegenerative complication of diabetes, involves complex pathological mechanisms including chronic hyperglycemia‑induced oxidative stress, inflammatory responses, microcirculatory disturban...
Current Development of Small Molecules Against Influenza A Virus by Targeting Hemagglutinin [0.03%]
针对血凝素的小分子抗流感病毒药物研究进展
Dandan Xu,Xinpeng Gu,Qiao Yu et al.
Dandan Xu et al.
Influenza A virus (IAV) continues to be one of the most serious health burdens causing widespread illness and mortality. Limited efficacy and reduced susceptibility of available drugs and vaccines to the emergence of resistant strains have ...
Late INa as a Therapeutic Target: New Strategies, Computational Modelling, Drug Development, and Clinical Translation [0.03%]
迟发性钠电流作为治疗靶点：新策略、计算建模、药物开发和临床转化
Arkapravo Chattopadhyay,Lynn C Lunsonga,Peter E Light et al.
Arkapravo Chattopadhyay et al.
The Nav1.5 channel, a major isoform of voltage-gated sodium ion channel, is mainly found in ventricular cardiomyocytes, playing a key role in generating essential cardiac action potentials for normal heart rhythms. Mutations in Nav1.5 have ...
Redefining CHI3L1: Therapeutic Opportunities at the Crossroads of Immune Suppression and Disease Progression [0.03%]
重新定义CHI3L1：免疫抑制和疾病进展交叉点的治疗机会
Kirti Upmanyu,Saurabh Upadhyay,Moustafa T Gabr
Kirti Upmanyu
Chitinase-3-like-1 (CHI3L1, also known as YKL-40) has been recognized as a biomarker of inflammation and tissue remodeling and has now emerged as a pseudoenzymatic immune checkpoint. Recent structural, immunological, and translational studi...
α-Synuclein Seeds Amplification Assays for Parkinson's Disease and Related Synucleinopathies [0.03%]
帕金森病及相关突触核蛋白病的α-突触核蛋白种子放大检测法
Rosalie Elvira,Qing Wang,Yun-Cheng Wu et al.
Rosalie Elvira et al.
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the pathological misfolding and aggregation of α-synuclein (α-syn), which leads to dopaminergic neuronal loss and multisystem dysfunction. Conventional ...
Beyond Bioenergetics: Moonlighting Functions of F1FO-ATPase From ATP Synthesis to an ATP-Wasting Death Switch [0.03%]
超越生物能量学：F₁F₀-ATP酶从合成ATP到消耗ATP的死亡开关的多功能性
Salvatore Nesci
Salvatore Nesci
Mitochondrial F1FO-ATPase is classically viewed as the "splendid" rotary nanomachine that sustains life by converting the proton-motive force (pmf) into ATP. Yet this same complex can adopt a second, context-dependent function that links bi...
Yuanyuan Zhang,Jiaxin Chen,Jiaqi Li et al.
Yuanyuan Zhang et al.
Viral proteases are critical targets in antiviral drug development due to their essential role in the viral lifecycle and high conservation across viral strains. This review summarizes the recent progress of antiviral drugs based on proteas...
Decoding the Toxicity of Synthetic Cannabinoids: From Receptor Activation to Multiorgan Dysfunction [0.03%]
合成大麻素的毒性机制研究：从受体激活到多器官功能障碍
Weihao Fan,Zhipeng Che,Li Xiao et al.
Weihao Fan et al.
Synthetic cannabinoids (SCBs) represent a rapidly expanding and chemically diverse class of new psychoactive substances, deliberately designed to mimic the effects of natural cannabis. However, their high potency and full agonism at cannabi...
AI-Driven Synthesis in Medicinal Chemistry: Integrating Large Language Models, Robotic Automation, and Sustainability Metrics to Accelerate Drug Discovery [0.03%]
基于人工智能的药物合成在医学化学中的应用：整合大型语言模型、机器人自动化和可持续性指标以加速药物发现
Amit Gangwal,Antonio Lavecchia
Amit Gangwal
Artificial intelligence (AI) is transforming synthetic chemistry from task-specific predictors into integrated platforms that unify retrosynthesis, reaction optimization, and closed-loop robotic automation. This review highlights how AI-ass...
Advances in Structural Diversity, Pharmacological Activities, and Drug Development of β-Carboline Alkaloids [0.03%]
β-咔啉类生物碱的结构多样性、药理活性及药物开发研究进展
Guo-Liang Mou,Tian-Li Dai,Bao-Qi Zhang et al.
Guo-Liang Mou et al.
β-Carboline alkaloids are natural products built around an indole-pyridine tricyclic core. Their relatively simple structure and ease of modification have drawn lasting interest from medicinal chemists. This review organizes their pharmaco...