The Therapeutic Potential of Melatonin and Its Novel Synthetic Analogs in Circadian Rhythm Sleep Disorders, Inflammation-Associated Pathologies, and Neurodegenerative Diseases [0.03%]
褪黑素及其新型合成类似物在生物钟睡眠障碍、与炎症相关的病理和神经退行性疾病方面的治疗潜力
Rodrigo F N Ribeiro,Marco Rios Santos,Maria Aquino et al.
Rodrigo F N Ribeiro et al.
Melatonin, N-acetyl-5-methoxytryptamine, is a tryptophan-derived hormone mostly produced in the pineal gland, despite being synthesized locally at several tissues and organs. This production is rhythmically controlled by complex clock gene ...
Harnessing the Power of Natural Products for Targeted Protein Degradation [0.03%]
利用天然产物进行靶向蛋白质降解的力量
Bo Zhu,Zheng Wu,Yiwen Shou et al.
Bo Zhu et al.
Natural products have garnered significant attention due to their complex chemical structures and remarkable pharmacological activities. With inherent recognition capabilities for protein surfaces, natural products serve as ideal candidates...
Compelling Evidence: A Critical Update on the Therapeutic Potential of Carbon Monoxide [0.03%]
毋庸置疑的证据：一氧化碳治疗潜力的重要更新
Nicola Bauer,Qiyue Mao,Aditi Vashistha et al.
Nicola Bauer et al.
Carbon monoxide (CO) is an endogenous signaling molecule. It is produced via heme degradation by heme oxygenase (HMOX), releasing stoichiometric amounts of CO, iron, and biliverdin (then bilirubin). The HMOX-CO axis has long been shown to o...
Subhabrata Chaudhury,Terin D&#x;Amico,Brian S J Blagg
Subhabrata Chaudhury
The beta isoform of 90 kDa heat shock protein (Hsp90β) plays a critical role in maintaining cellular proteostasis by assisting in the folding and refolding of proteins, which is essential for both normal cellular function and stress respon...
The Quinoline Photoremovable Group (PPG) Platform-A Medicinal Chemist's Approach for Photocage Development and Applications [0.03%]
含喹啉光保护基团（PPGs）平台——药物化学视角下的光保护基开发及应用
Bence Kontra,Zoltán Mucsi,Janez Ilaš et al.
Bence Kontra et al.
Photoremovable protecting groups (PPGs) offer a straightforward solution for the temporary inactivation of biologically active substrates and their subsequent controlled release by light irradiation. Their relatively easy design and mode of...
Molecular Tools to Study and Control Dopaminergic Neurotransmission With Light [0.03%]
用光来研究和控制多巴胺能神经传递的分子工具
Galyna Maleeva,Carlo Matera,Silvia Roda et al.
Galyna Maleeva et al.
Dopaminergic neurotransmission is involved in several important brain functions, such as motor control, learning, reward-motivated behavior, and emotions. Dysfunctions of dopaminergic system may lead to the development of various neurologic...
Marine Natural Products in Inflammation-Related Diseases: Opportunities and Challenges [0.03%]
海洋天然产物在炎症相关疾病中的机遇与挑战
Tao Zhang,Zijun Ouyang,Yueran Zhang et al.
Tao Zhang et al.
In recent decades, the potentiality of marine natural products (MNPs) in the medical field has been increasingly recognized. Natural compounds derived from marine microorganisms, algae, and invertebrates have shown significant promise for t...
A Bright Future for Photopharmaceuticals Addressing Central Nervous System Disorders: State of the Art and Challenges Toward Clinical Translation [0.03%]
光药剂治疗中枢神经系统障碍的光明前景：临床转化面临的机遇与挑战
Rudolf L Z Ganzoni,Sofie S Bournons,Erick M Carreira et al.
Rudolf L Z Ganzoni et al.
Photopharmacology is an innovative approach that uses light to activate drugs. This method offers the potential for highly localized and precise drug activation, making it particularly promising for the treatment of neurological disorders. ...
Shuang Shi,Yangzhi Cao,Maikel Wijtmans et al.
Shuang Shi et al.
Adrenoceptors (ARs) play a vital role in various physiological processes and are key therapeutic targets. The advent of optical control techniques, including optogenetics and photopharmacology, offers the potential to modulate AR signaling ...
Light-Activated Pharmacological Tools for Exploring the Cholinergic System [0.03%]
用于探究胆碱能系统的光激活药理工具
Alessio Colleoni,Giulia Galli,Clelia Dallanoce et al.
Alessio Colleoni et al.
Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and tem...