Differential Astrocyte-Supplied NMDAR Co-Agonist for CA1 Versus Dentate Gyrus Long-Term Potentiation [0.03%]
CA1与齿状回长时程增强的星形胶质细胞提供的NMDA受体协同激动剂差异性研究
Shruthi Sateesh,Wickliffe C Abraham
Shruthi Sateesh
In the hippocampus, there is a region- and synapse-specific N-methyl-D-aspartate receptor (NMDAR) co-agonist preference for induction of long-term potentiation (LTP). Schaffer collateral (SC)-CA1 synapses, enriched in GluN2A-containing NMDA...
Hippocampal Morphological Alterations and Oxidative Stress in Autism Spectrum Disorder Model Induced by Prenatal Exposure to Valproic Acid in Male and Female Mice [0.03%]
孕期暴露于丙戊酸钠的小鼠体内氧化应激及自闭症模型海马形态变化的性别差异研究
Zineb Bouargane,Fatima-Zahra Lamghari Moubarrad,Youssef Anouar et al.
Zineb Bouargane et al.
Valproic acid (VPA), a first-line antiepileptic and mood-stabilizing drug, has been linked to congenital malformations, cognitive disabilities, and an elevated risk of autism spectrum disorder (ASD) when used during pregnancy. ASD is a life...
Resting-State Functional Connectivity With the Anterior and Posterior Hippocampus: An Analysis of fMRI Data From the Human Connectome Project [0.03%]
静息态下海马前、后两端的功能连接研究——来自人类连接组计划的fMRI数据的分析
Haley A Fritch,Ashley C Steinkrauss,Scott D Slotnick
Haley A Fritch
The anterior and posterior hippocampus exhibit distinct patterns of connectivity and are consequently hypothesized to have distinct functions. While there is evidence that the posterior hippocampus interacts with the default network and the...
Jose A Fernandez-Leon
Jose A Fernandez-Leon
Neurons linked to spatial navigation and toroidal dynamics in the mouse medial entorhinal cortex (MEC) show unexpected minute-scale (< 0.01 Hz) oscillatory sequences without neural organization or clear relation to behavior. However, the co...
Chronic α5-GABA-A Receptor Potentiation Promotes Mouse Adult Hippocampal Neurogenesis [0.03%]
慢性α5-GABAA受体强化促进小鼠海马神经发生
Thomas D Prevot,Michael Marcotte,Denis J David et al.
Thomas D Prevot et al.
Several lines of evidence implicate adult hippocampal neurogenesis (AHN) in cognitive functions, in mood- and anxiety-related behaviors, and in the therapeutic effects of antidepressants. Augmenting α5-γ-Aminobutyric acid type A (GABAA) r...
Combined Effects of Intermittent Hypoxia and Amyloid Beta on Hippocampal Activity, Its Cholinergic Modulation, and Memory [0.03%]
间断性缺氧和β淀粉样蛋白对海马区活性、胆碱能调节及记忆的联合影响
Pinedo-Vargas Laura,Méndez-Salcido Felipe,Lorea-Hernández Jonathan-Julio et al.
Pinedo-Vargas Laura et al.
Obstructive sleep apnea (OSA), characterized by repetitive upper airway obstruction, leads to chronic intermittent hypoxia (cIH) and induces cognitive and neuronal network disruptions similar to those observed in Alzheimer's disease (AD). T...
Mi Wang,Rebekah van Bruggen,Lanah Mohammed et al.
Mi Wang et al.
Adult hippocampal neurogenesis (AHN) is the process by which new neurons are continuously generated from neural stem and progenitor cells (NSPCs) in the adult dentate gyrus. AHN plays a pivotal role in cognitive functions, including learnin...
Transient DREADD Manipulation of the Dorsal Dentate Gyrus in Rats Impairs Initial Learning of Place-Outcome Associations [0.03%]
光遗传学操控齿状回背侧临时干扰空间位置学习记忆的初始阶段
J Lim,A Souiki,P Ahmad et al.
J Lim et al.
The dentate gyrus subfield of the hippocampus is thought to be critically involved in the disambiguation of similar episodic experiences and places in a context-dependent manner. However, most empirical evidence has come from lesion and gen...
A Theory and Model of Scene Representations With Hippocampal Spatial View Cells [0.03%]
基于海马空间视图神经元的场景表征理论与模型
Edmund T Rolls
Edmund T Rolls
A theory and network model are presented of how scene representations are built by forming spatial view cells in the ventromedial visual cortical scene pathway to the hippocampus in primates including humans. Layer 1, corresponding to V1-V4...