Tau PET Burden Is Associated With Hippocampal Microstructure and Episodic Memory in Amyloid Positive Older Adults [0.03%]
tau-PET负荷与淀粉样蛋白阳性老年人海马微结构和情景记忆有关
Daniel D Callow,Nisha Rani,Kylie H Alm et al.
Daniel D Callow et al.
Growing evidence suggests that hippocampal gray matter microstructure, assessed through diffusion-weighted imaging (DWI), is a sensitive marker of neurodegeneration in Alzheimer's disease (AD). While hippocampal atrophy is a characteristic ...
Lateralization of Hippocampal Dentate Spikes and Sharp-Wave Ripples in Urethane Anesthetized Rats Depends on Cholinergic Tone [0.03%]
胆碱能张力依赖的大麻利醇麻醉大鼠海马齿状回尖波尖峰的侧化现象
Miriam S Nokia,Sanna Lensu,Suvi-Maaria Lehtonen et al.
Miriam S Nokia et al.
Neural activity and bodily functions are inherently rhythmic and related to each other. The occurrence of hippocampal sharp-wave ripples (SPW-Rs) and dentate spikes (DSs) supporting memory consolidation is regulated by the overall state of ...
Andrew P Yonelinas
Andrew P Yonelinas
Our understanding of how the medial temporal lobe (MTL) contributes to human cognition has advanced enormously over the past half a century. My work in the 1990s characterizing the role of recollection and familiarity processes in episodic ...
Impact of Dendritic Spine Loss on Excitability of Hippocampal CA1 Pyramidal Neurons: A Computational Study of Early Alzheimer Disease [0.03%]
计算研究阿尔茨海默病早期锥体神经元树突棘丢失对其兴奋性的影响：海马CA1区 pyramidal neurons的初步研究报告
Chengju Tian,Isabel Reyes,Alexandra Johnson et al.
Chengju Tian et al.
Synaptic spine loss is an early pathophysiologic hallmark of Alzheimer disease (AD) that precedes overt loss of dendritic architecture and frank neurodegeneration. While spine loss signifies a decreased engagement of postsynaptic neurons by...
Combinative Protein Expression of Immediate Early Genes c-Fos, Arc, and Npas4 Along Aversive and Appetitive Experience-Related Neural Networks [0.03%]
c-Fos、Arc和Npas4即早基因沿负向和正向体验相关神经网络的组合表达分析
Mary Arai,Hisayuki Osanai,Chris C Snell et al.
Mary Arai et al.
Expression of immediate early genes (IEGs) is critical for memory formation and has been widely used to identify the neural substrate of memory traces, termed memory engram cells. Functions of IEGs have been known to be different depending ...
Inferior and Middle Longitudinal Fasciculus and Fornix Support Allocentric Representation [0.03%]
下纵束和海马连丝支撑镜像坐标系下的空间定位记忆功能
Hallvard Røe Evensmoen,Lars M Rimol,Asta Håberg
Hallvard Røe Evensmoen
If a map-like representation in the brain originates within a distributed network of brain regions, then this network should be underpinned by white-matter pathways. To test this, we had 83 young adults learn 15 virtual environments through...
Abigail L Yu,Laura A DeNardo
Abigail L Yu
Memories formed in adulthood can last a lifetime, whereas those formed early in life are rapidly forgotten through a process known as infantile amnesia. In recent years, tremendous progress has been made in understanding the memory engram-t...
Differentiated Presynaptic Input to OLMɑ2 Cells Along the Hippocampal Dorsoventral Axis: Implications for Hippocampal Microcircuit Function [0.03%]
齿状回至CA3神经元的兴奋性突触传递的短期和长期抑制：海马体GABA能中间神经元的作用
Angelica Thulin,Katharina Henriksson,Ingrid Nogueira et al.
Angelica Thulin et al.
The dorsal and ventral hippocampus have distinct processing properties, but it remains unclear if interneuron subtypes differ in connectivity along the dorsoventral axis. Oriens lacunosum-moleculare (OLM) interneurons, identified by the Chr...
Evidence of Disrupted Hippocampal Gray- and White-Matter Development in Adolescent Anxiety Disorders, Independent From Early-Life Stress [0.03%]
青少年焦虑障碍中海马灰质和白质发育异常的证据，独立于早期生活应激之外
Karina Pedroza-Sotelo,Hillary Schwarb,Randy P Auerbach et al.
Karina Pedroza-Sotelo et al.
Early-life stress and depression among youths are linked to hippocampal gray- and white-matter alterations. Less is known about hippocampal alterations in adolescent anxiety disorders (Anx) or the role that stress or comorbid depressive dis...
Developing an Anatomically Valid Segmentation Protocol for Anterior Regions of the Medial Temporal Lobe for Neurodegenerative Diseases [0.03%]
针对神经退行性疾病的海马区解剖学分隔方案的制定与发展
Niyousha Sadeghpour,Sydney A Lim,Anika Wuestefeld et al.
Niyousha Sadeghpour et al.
The anterior portion of the medial temporal lobe (MTL) is one of the first regions targeted by pathology in sporadic Alzheimer's disease (AD) and limbic-predominant age-related TDP-43 encephalopathy (LATE) indicating a potential for metrics...