Notes on the History of In Vitro Hippocampal Electrophysiology and LTP: Personal Reflections [0.03%]
有关离体海马电生理学和LTP历史的笔记：个人反思
Bradley E Alger
Bradley E Alger
This essay describes the development of the in vitro hippocampal slice technique and my small contributions to it and to influencing Roger Nicoll's early interests in the hippocampus and LTP. My Ph.D. work at Harvard with Timothy Teyler was...
Longitudinal Excitation and Lamellar Feedforward Inhibition of the Hippocampal CA3 to CA1 Projections [0.03%]
海马CA3至CA1投射的纵向激励和层状前馈抑制
Kazuki Okamoto,Masato Koike,Hiroyuki Hioki
Kazuki Okamoto
The hippocampus is a longitudinally extended brain structure characterized by its classic trisynaptic circuit, comprising the dentate gyrus (DG), CA3, and CA1 subregions, evident in transverse slices and consistent throughout the hippocampa...
Neurobehavioral Approach to the Study of Memory Development: A Personal Journey [0.03%]
记忆发展的神经行为研究方法：个人经历分享
Jocelyne Bachevalier
Jocelyne Bachevalier
This manuscript covers my personal history on the search for the neural circuits supporting early developing memory in primates. A series of developmental neuropsychological studies is presented to follow the successive knowledge we gained ...
An Accidental Journey Into the Black Hole of the Hippocampus and How We Learned About What Makes a Context a Context [0.03%]
误入海马体的黑洞以及我们是如何了解是什么构成了情境的故事
Michael S Fanselow
Michael S Fanselow
In this commentary, I recount my personal research journey that brought me to studying the hippocampus, which I vigorously avoided earlier in my career. I focus on studies of contextual fear conditioning and how they led me in this directio...
Altered Coding of Environmental Boundaries in Human Aging: An fMRI Study [0.03%]
人类衰老中环境边界编码的改变：一项fMRI研究
Vladislava Segen,Matthias Stangl,Jonathan Shine et al.
Vladislava Segen et al.
Aging is associated with changes in spatial memory and navigation, yet the mechanisms underlying these changes are not yet fully understood. Environmental boundaries are among the most salient and reliable spatial cues, supporting both spat...
β-Adrenergic Receptor Activation Modulates the Induction of Complex Spike-Dependent LTP by Regulating Multiple Forms of Heterosynaptic Plasticity [0.03%]
β肾上腺素受体激活通过调节多种形式的异突触可塑性来调控复合棘波依赖的长时程增强的诱导
Thomas J O&#x;Dell
Thomas J O&#x;Dell
Norepinephrine, acting through β-adrenergic receptors (β-ARs), has a key role in hippocampus-dependent forms of learning. Although β-AR activation also facilitates the induction of Hebbian LTP, recent findings indicate that a non-Hebbian...
Ketamine Sustains and Enhances the Protective Effects of a Ketogenic Diet Against Relapses in an Anorexia Mouse Model [0.03%]
氯胺酮可持续并增强生酮饮食在厌食症小鼠模型中预防复发的保护作用
Yiru Dong,Jundi Wang,Olivia Ge et al.
Yiru Dong et al.
Anorexia nervosa (AN) has high mortality and relapse rates, yet no accepted pharmacotherapies. Reports based on six individuals suggest that ketogenic diet (KGD) combined with sub-anesthetic ketamine (KET) is an effective treatment. The ani...
Automatic Segmentation of Medial Temporal Lobe Subregions in Multi-Scanner, Multi-Modality Magnetic Resonance Imaging of Variable Quality [0.03%]
多扫描仪、多种模态磁共振成像的海马亚区自动分割算法及其在不同质量图像中的应用
Yue Li,Long Xie,Pulkit Khandelwal et al.
Yue Li et al.
Volumetry of subregions in the medial temporal lobe (MTL) computed from automatic segmentation in MRI can track neurodegeneration in Alzheimer's disease. However, poor quality MR images can lead to unreliable segmentation of MTL subregions....
Drug-Related Engrams and Their Role in the Persistence and Recurrence of Drug-Related Behaviors [0.03%]
药物刻板记忆及其在药物相关行为的持续和复发中的作用
M Cutler,A Thati,S L Grella
M Cutler
Memory is a cornerstone of human behavior, and addiction offers a compelling model of its persistence and plasticity. The scope of engram research has rapidly expanded to include addiction-related phenomena. Addiction-related memories, like...
Changes in Naturalistic Viewing in Healthy Aging and Amnestic Mild Cognitive Impairment [0.03%]
健康老龄化和轻度认知障碍患者的自然视野变化规律研究
Anisha Khosla,Jordana S Wynn,Arber Kacollja et al.
Anisha Khosla et al.
Visual exploration-where the eyes move and when-is guided by prior experiences. Memory-guided viewing behavior is altered in healthy aging and is further disrupted in amnestic mild cognitive impairment (aMCI), a condition in which there is ...