APOE ɛ4 constrains engagement of encoding-related compensatory networks in amnestic mild cognitive impairment [0.03%]
载脂蛋白ε4限制了编码相关代偿网络在遗忘性轻度认知障碍中的作用
Laura Prieto del Val,Jose L Cantero,Mercedes Atienza
Laura Prieto del Val
People with amnestic mild cognitive impairment (aMCI), compared to healthy older adults (HO), benefit less from semantic congruent cues during episodic encoding. The presence of the apolipoprotein E (APOE) ɛ4 makes this congruency benefit ...
Fornical and nonfornical projections from the rat hippocampal formation to the anterior thalamic nuclei [0.03%]
关于海马回对前丘脑核群 fornical 和非 fornical 投射的研究
Christopher M Dillingham,Jonathan T Erichsen,Shane M O&#x;Mara et al.
Christopher M Dillingham et al.
The hippocampal formation and anterior thalamic nuclei form part of an interconnected network thought to support memory. A central pathway in this mnemonic network comprises the direct projections from the hippocampal formation to the anter...
Selection for tameness, a key behavioral trait of domestication, increases adult hippocampal neurogenesis in foxes [0.03%]
选育出的温顺性，即家养的关键行为特征，增加了狐成年海马神经发生率
Shihhui Huang,Lutz Slomianka,Andrew J Farmer et al.
Shihhui Huang et al.
Work on laboratory and wild rodents suggests that domestication may impact on the extent of adult hippocampal neurogenesis and its responsiveness to regulatory factors. There is, however, no model of laboratory rodents and their nondomestic...
Semantic retrieval over time in the aging brain: Structural evidence of hippocampal contribution [0.03%]
老化大脑中语义检索的时间结构证据：海马体的贡献
Gwénaëlle Catheline,Hélène Amieva,Bixente Dilharreguy et al.
Gwénaëlle Catheline et al.
This study investigates relationship between regional cerebral volumes and performances over time of a categorical fluency task, in a sample of older adults (n = 316). Using voxel-wise technique, the relationship between local grey matter v...
Multicenter Study
Hippocampus. 2015 Sep;25(9):1008-16. DOI:10.1002/hipo.22423 2015
Diagnostic differentiation of mild cognitive impairment due to Alzheimer's disease using a hippocampus-dependent test of spatial memory [0.03%]
阿尔茨海默病轻度认知障碍的诊断性鉴别：使用一种与海马体有关的空间记忆测试
Kuven Moodley,Ludovico Minati,Valeria Contarino et al.
Kuven Moodley et al.
The hippocampus is one of the earliest brain regions affected in Alzheimer's disease (AD) and tests of hippocampal function have the potential to detect AD in its earliest stages. Given that the hippocampus is critically involved in allocen...
Multicenter Study
Hippocampus. 2015 Aug;25(8):939-51. DOI:10.1002/hipo.22417 2015
Dentate total molecular layer interneurons mediate cannabinoid-sensitive inhibition [0.03%]
齿状回总分子层内侧神经元介导阿片受体敏感型抑制作用
Jiandong Yu,Bogumila Swietek,Archana Proddutur et al.
Jiandong Yu et al.
Activity of the dentate gyrus, which gates information flow to the hippocampus, is under tight inhibitory regulation by interneurons with distinctive axonal projections, intrinsic and synaptic characteristics and neurochemical identities. T...
Blockade of intracellular Zn2+ signaling in the dentate gyrus erases recognition memory via impairment of maintained LTP [0.03%]
通过抑制维持性长时程增强以消除识别记忆：海马齿状回内锌离子信号转导的阻断作用
Haruna Tamano,Tatsuya Minamino,Hiroaki Fujii et al.
Haruna Tamano et al.
There is no evidence on the precise role of synaptic Zn2+ signaling on the retention and recall of recognition memory. On the basis of the findings that intracellular Zn2+ signaling in the dentate gyrus is required for object recognition, s...
The relationship between gamma frequency and running speed differs for slow and fast gamma rhythms in freely behaving rats [0.03%]
自由活动大鼠慢伽玛和快伽玛节律的频率与运行速度的关系不同
Chenguang Zheng,Kevin Wood Bieri,Sean Gregory Trettel et al.
Chenguang Zheng et al.
In hippocampal area CA1 of rats, the frequency of gamma activity has been shown to increase with running speed (Ahmed and Mehta, 2012). This finding suggests that different gamma frequencies simply allow for different timings of transitions...
Hippocampal dendritic spines remodeling and fear memory are modulated by GABAergic signaling within the basolateral amygdala complex [0.03%]
侧隔核复合体中的GABA能信号调控海马树突棘的重塑和恐惧记忆形成
Marcelo Giachero,Gaston D Calfa,Victor A Molina
Marcelo Giachero
GABAergic signaling in the basolateral amygdala complex (BLA) plays a crucial role on the modulation of the stress influence on fear memory. Moreover, accumulating evidence suggests that the dorsal hippocampus (DH) is a downstream target of...
Aberrant NMDA-dependent LTD after perinatal ethanol exposure in young adult rat hippocampus [0.03%]
孕期接触乙醇可导致幼年大鼠海马NMDA依赖性 LTD异常
Myriam Kervern,Benoît Silvestre de Ferron,Stéphanie Alaux-Cantin et al.
Myriam Kervern et al.
Irreversible cognitive deficits induced by ethanol exposure during fetal life have been ascribed to a lower NMDA-dependent synaptic long-term potentiation (LTP) in the hippocampus. Whether NMDA-dependent long-term depression (LTD) may also ...