Micro-Stimulation Timing Framed Around an Averaged Theta Period of Stimulation Determines Hippocampal Recruitment in Cued Fear Conditioning [0.03%]
Paula Gonçalves Vieira Teixeira,Leonardo de Oliveira Guarnieri,Grace Schenatto Pereira et al.
Paula Gonçalves Vieira Teixeira et al.
The importance of precise timing of neuronal activity, relative to ongoing slower oscillations, is reshaping the engram theory and our understanding of how memories are encoded and stored. The hippocampal theta-wave phase-encoding of neuron...
Dmitrii Shipkov,Daria Vinokurova,Karina Tukhvatullina et al.
Dmitrii Shipkov et al.
Early activity patterns support the development of neuronal networks by promoting synaptic plasticity. In the hippocampus of neonatal rats and mice in vivo, early sharp waves (eSPWs) are the first pattern of synchronized network activity. T...
Dissociable Mechanisms Underlie Differences Between Memory and Metamemory in Older Adults: The Differentiating Role of Anxiety and Depression Symptoms [0.03%]
Jennifer L Crawford,Alex A Adornato,Johanna Matulonis et al.
Jennifer L Crawford et al.
The ability to remember (i.e., memory ability) and to accurately discern memory function (i.e., metamemory) are both important facets of cognition. In the present study, we examined the shared and distinct sources of variance across memory ...
Tina Ciric,Shaina P Cahill,Tyler Lin et al.
Tina Ciric et al.
Adult-born hippocampal neurons are highly plastic but there remains uncertainty about the magnitude of neurogenesis and its long-term functional consequences. Theoretical predictions indicate that adult neurogenesis should lead to substanti...
Subsets of Single Neurons Predict Ensemble Activity and Memory Choices [0.03%]
单个神经元的子集预测神经元群体活动和记忆选择
Aditya Srinivasan,Aditya Behal,Kevin Guise et al.
Aditya Srinivasan et al.
Finding elements of a complex network which contribute most to the network's overall behavior is an open problem in various fields. This challenge is particularly difficult in neuroscience as it requires identifying which of a mammalian bra...
The Role of Plasticity in Replay: Stability Through Anti-Hebbian Rules [0.03%]
可塑性在回放中的作用：通过反赫布规则实现稳定性
Lior Baron,Kamran Diba,Asohan Amarasingham
Lior Baron
Hippocampal replay is now considered to be a cornerstone of memory consolidation, yet the synaptic plasticity rules governing its dynamics remain elusive. Under the standard asymmetric Hebbian spike-timing dependent plasticity (STDP) model,...
Attentional Deficits Do Not Explain Age-Related Impairments on the Mnemonic Similarity Task [0.03%]
注意缺陷无法解释记忆相似任务中的年龄相关损害
Casey R Vanderlip,Hasan Salim,Alexis Houle et al.
Casey R Vanderlip et al.
The Mnemonic Similarity Task (MST) is increasingly used to assess mnemonic discrimination and has become a valuable tool for detecting subtle cognitive decline in aging and early Alzheimer's disease. Although designed to target hippocampal ...
Stress-Enhanced Fear Learning (SEFL) Is Associated With Enhanced Reactivation of Fear Engrams in Caudal But Not Rostral Dentate Gyrus [0.03%]
应激增强恐惧记忆(S-EFM)与海马齿状回尾部而非头部的恐惧痕迹重新激活增加有关
Denisse Paredes,Michael R Drew
Denisse Paredes
Traumatic stress can cause long-lasting changes in cognition and affect, sometimes leading to diagnoses such as posttraumatic stress disorder (PTSD). The stress-enhanced fear learning (SEFL) model recapitulates understudied components of PT...
rTCT: Rodent Triangle Completion Task to Facilitate Reverse Translational Study of Path Integration [0.03%]
基于路径积分的反向翻译研究——啮齿动物三角补全任务(rTCT)的设计与验证
Stephen Duncan,Sulaiman Rehman,Vladislava Segen et al.
Stephen Duncan et al.
Path integration is navigation in the absence of environmental landmarks and is a primary cognitive mechanism underlying spatial memory. Path integration performance is primarily assessed in humans using the Triangle Completion Task (TCT). ...
Synaptic Potentiation in Hippocampus by eEF2K Inhibitor A484954 [0.03%]
hippocampal长时程增强由eEF2K抑制剂A484954诱导
Qian Yang,Tian Li,Hannah M Jester et al.
Qian Yang et al.
An important mechanism controlling protein synthesis is through phosphorylation of the eukaryotic elongation factor 2 (eEF2) by its kinase eEF2K. Hyperphosphorylation of eEF2 is linked to many neuronal diseases characterized by cognitive im...