Construction of a Diagnostic Model and Drug Prediction for Postischemic Stroke Cognitive Impairment Based on Machine Learning Screening of Lactate Metabolism- and Pyroptosis-Related Genes [0.03%]
基于机器学习筛选乳酸代谢和细胞焦亡相关基因的缺血性卒中后认知障碍诊断模型构建及药物预测研究
Shulong Ge,Qiying Zhang,Ning Liu et al.
Shulong Ge et al.
Reliable molecular biomarkers for poststroke cognitive impairment (PSCI) remain limited. Using publicly available bulk transcriptomic and single-cell RNA-seq datasets from GEO, we investigated lactate metabolism- and pyroptosis-related sign...
Identification of a Germline XAF1 Mutation in Patients With Gastrointestinal Cancers [0.03%]
在胃肠道癌症患者中鉴定出XAF1基因胚系突变
Guan-Xin Xu,Hang Zhang,Chang-Xing Wang et al.
Guan-Xin Xu et al.
Background: Gastrointestinal (GI) cancers can be attributed to the interplay between genetic and environmental factors. To date, apart from certain cancer syndromes, the genetic factors underlying familial GI cancers have...
GLUT1 rs1385129G>A Raised the Risk and Poor Prognosis of Lung Cancer: A Case-Control Study [0.03%]
GLUT1基因rs1385129G>A位点多态性与肺癌易感性和预后研究
Zhi Li,Dedong Wang,Jinbin Chen et al.
Zhi Li et al.
Background: Energy metabolism reprogramming of cancer cells with the abnormal glycolytic capacity represents a novel direction of tumor therapy. Nevertheless, there is a lack of evidence linking genetic variations in glyc...
A Single-Cell Multiomics Pipeline Maps YBX1 as a Functional Biomarker for Immune Evasion and Therapeutic Resistance in Prostate Adenocarcinoma [0.03%]
单细胞多组学管道将YBX1映射为前列腺腺癌免疫逃逸和治疗抗性的功能生物标志物
Changcheng Luo,Dongxu Lin,Jingmin Yang et al.
Changcheng Luo et al.
Translating high-resolution multiomics data into clinically actionable biomarkers is critical for overcoming therapeutic resistance and tumor heterogeneity in prostate adenocarcinoma (PRAD). To decode the complex immunosuppressive tumor mic...
Exploring the Role of HNRNPA3 in Breast Cancer Progression, Immune Microenvironment, and Therapeutic Sensitivity: A Multiomics and Functional Prediction Study [0.03%]
探索HNRNPA3在乳腺癌进展、免疫微环境和治疗敏感性中的作用：一项多组学和功能预测研究
Lijie Gong,Yang Xu,Weihui Guo et al.
Lijie Gong et al.
Background: Breast invasive carcinoma (BRCA) remains a leading cause of female cancer mortality, necessitating novel biomarkers and therapeutic targets. Heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3) emerges as a po...
Whole-Exome Sequencing to Screen Personal Neoantigens With High Immunogenicity in Patients With Microsatellite Stability (MSS)-Advanced Colorectal Cancer [0.03%]
用于筛查高免疫原性个人新抗原的全外显子组测序在微卫星稳定(MSS)型晚期结直肠癌患者中的应用
Dajiang Li,Wenjing Shen,Siyu Yang et al.
Dajiang Li et al.
To develop a personalized neoantigen therapy strategy for microsatellite stability (MSS)-advanced colorectal cancer (CRC), neoantigens from collected human CRC samples were screened, and the feasibility and effectiveness of these neoantigen...
Periostin Safeguards EGFR-Driven Genomic Instability and Sustains the Immune-Suppressive Niche in Glioblastoma [0.03%]
periostin通过保护EGFR驱动的基因组不稳定性和维持胶质母细胞瘤免疫抑制微环境来促进胶质母细胞瘤的发展
Hongjun Liu,Shasha Tan,Jian Qi et al.
Hongjun Liu et al.
Glioblastoma (GBM) heterogeneity limits the efficacy of EGFR-targeted therapies. Here, we present a spatially stratified single-cell atlas of IDH-wildtype GBM to dissect the impact of EGFR amplification on tumor architecture. We demonstrate...
Multiomics Analysis of Nucleotide Metabolism Highlights the Important Role of Adenylate Kinase 4 in Pancreatic Cancer [0.03%]
核苷酸代谢的多组学分析揭示了腺苷酸激酶4在胰腺癌中的重要作用
Jun Li,Yiqun Yao,Wei Zhang et al.
Jun Li et al.
Nucleotide metabolism significantly influences tumor cell proliferation, yet its specific profile in pancreatic cancer remains inadequately understood. This study was aimed at characterizing the nucleotide metabolic profile in pancreatic ca...
Pathophysiological Significance of Variants of the HAND1 Gene Promoter in Congenital Atrial Septal Defects: A Study in 632 Chinese Subjects [0.03%]
HAND1基因启动子变异在中国先天性房间隔缺损中的病理生理意义：一项包含632例受试者的队列研究
Jia-Le Qi,Huan-Xin Chen,Hai-Tao Hou et al.
Jia-Le Qi et al.
Background: Atrial septal defect (ASD) is a common congenital heart disease (CHD) and genetic variation in the HAND1 gene is associated with cardiac development. The variants in the promoter region of the HAND1 gene are u...
Ubiquitination-Associated Ductal-Fibroblast Crosstalk Shapes Tumor Progression and Prognosis in Pancreatic Ductal Adenocarcinoma [0.03%]
泛素化相关的导管上皮-成纤维细胞相互作用塑造胰腺导管腺癌的进展和预后
Yiping Fu,Xin Zhou,Lai Jiang et al.
Yiping Fu et al.
Background: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy characterized by a complex tumor microenvironment. Ubiquitination regulates key oncogenic processes and microenvironmental remodeling; howeve...