Integrating Bulk and Single-Cell RNA-Seq Reveals Glycolysis-Associated Macrophages and Its Related Tumor Subgroup Signatures to Predict Prognosis and Therapy in Clear Cell Renal Cell Carcinoma [0.03%]
整合批量和单细胞RNA测序揭示糖酵解相关巨噬细胞及其相关的肿瘤亚型特征以预测透明细胞肾细胞癌的预后和治疗效果
Yang Li,Yuan Chen,Ling Wang et al.
Yang Li et al.
Background: Clear cell renal cell carcinoma (ccRCC) is the most common histological type of RCC and is marked by aggressive nature and poor survival. However, therapeutic options remain limited and yield suboptimal outcom...
Integrative Mendelian Randomization and Multiomics Analysis Identifies CAF-Derived Complement Factor B as a Prognostic Biomarker and Therapeutic Vulnerability in Breast Cancer [0.03%]
整合型孟德尔随机化和多组学分析识别出乳腺癌中的CAFs衍生补体因子B作为预后生物标志物和治疗弱点
Hong Xiang,Na Ren,Ting Wang et al.
Hong Xiang et al.
Background: Complement factor B (CFB), a key component of the alternative complement pathway, has been implicated in tumor-related inflammation; however, its causal role and therapeutic relevance in breast cancer remain u...
Integrative Systems Biology and Experimental Validation Unveil GALNT14 as a Novel Diagnostic Biomarker and Therapeutic Target for Sepsis [0.03%]
整合系统生物学和实验验证发现GALNT14是脓毒症的新型诊断生物标志物和治疗靶点
Xiuqi Zhu,Yi Zhai,Jiali Yao et al.
Xiuqi Zhu et al.
Background: Sepsis lacks reliable biomarkers for early diagnosis and treatment. This study integrates systems biology approaches, weighted gene coexpression network analysis (WGCNA), and experimental validation to identif...
A Propionate Metabolism-Based Gene Signature Reveals Immunogenomic and Transcriptomic Determinants of Prognosis in Glioblastoma Through Multiomics Integration [0.03%]
一种基于丁酸代谢的基因标志物通过多组学整合揭示了胶质母细胞瘤预后免疫和转录组决定因素
Mengtong Li,Jiayi Liu,Zichen Liu et al.
Mengtong Li et al.
Glioblastoma (GBM) remains a lethal brain tumor with limited prognostic tools. Metabolic reprogramming, particularly in understudied pathways like propionate metabolism, may offer new biomarkers. Here, we identified a novel prognostic signa...
Secretory Lysosome-Related Gene Signature Defines the Immune Microenvironment and Identifies RGS2 as a Prometastatic Factor in Hepatocellular Carcinoma [0.03%]
分泌溶酶体相关基因特征定义了肝细胞癌的免疫微环境并鉴定出RGS2为促转移因子
Zhipeng Ye,BuLang Tang,Yuanjian Zhang et al.
Zhipeng Ye et al.
Introduction: Hepatocellular carcinoma (HCC) is a highly aggressive tumour with significant heterogeneity and a poor response to immunotherapy. Secretory lysosomes (SLs) control immunological responses and cellular homeos...
Integrative Analysis of Vitamin D-Associated Genetic Variants Reveals Cis-Regulatory Architecture and Multigenic Mechanisms Underlying Chronic Disease-Relevant Pathways [0.03%]
整合分析维生素D相关的基因多态性，揭示慢性病相关通路的顺式调控结构和多基因机制
Jia Yue,Jinqing Zhang,Ke Xu et al.
Jia Yue et al.
Vitamin D is a pleiotropic regulator of immune, metabolic, and endocrine homeostasis and has been implicated in a broad spectrum of chronic diseases. Although genome-wide association studies (GWAS) have identified numerous genetic variants ...
Integrative Single-Cell and Spatial Transcriptomics Reveal Organelle Stress-Associated Heterogeneity and Immune Microenvironment Remodeling in Lung Adenocarcinoma [0.03%]
整合单细胞和空间转录组揭示肺腺癌中的器官应激相关异质性和免疫微环境重塑
Xiaoyan Chang,Meifeng Li,Chenghao Wang et al.
Xiaoyan Chang et al.
Background: Lung adenocarcinoma (LUAD) exhibits marked heterogeneity. Organelle stress-adaptive programs that tumor cells develop under hypoxia, nutrient limitation, and proteostasis pressure may drive functional reprogra...
Integrated Bulk and Single-Cell Transcriptomic Analysis Reveals Xenobiotic Metabolism Genes Drive Progression From Liver Cirrhosis to Hepatocellular Carcinoma [0.03%]
综合性状和单细胞转录组分析揭示外源物质代谢基因驱动肝硬化向肝细胞癌发展
Hao Xu,Yanpeng Li,Rui Zhao et al.
Hao Xu et al.
Background: Hepatocellular carcinoma (HCC) is one of the most prevalent malignant tumors globally, with liver cirrhosis (LC) recognized as a significant precursor. Xenobiotic metabolism plays a pivotal role in liver disea...
Role of Macrophage-Related Genes GAS7 and ZEB2 in Acute Myocardial Infarction Pathogenesis [0.03%]
GAS7和ZEB2基因在急性心肌梗死发病机制中的巨噬细胞相关作用研究
Zhenfang Liu,Jia Song,Lingling Li et al.
Zhenfang Liu et al.
Background: Acute myocardial infarction (AMI) involves complex immune responses and cellular interaction mechanisms. Although the pathogenesis of AMI is now preliminarily understood, there is still a lack of biomarkers th...
Decoding Pathogenic Mutational Landscapes in Alzheimer's Disease Through Integrated Transcriptomics [0.03%]
整合转录组学解析阿尔茨海默病致病突变图谱
Wan Ma,Fenfang Zhou,Huaying Cai et al.
Wan Ma et al.
Alzheimer's disease (AD) is increasingly understood as a disorder driven not only by amyloid and tau pathology but also fundamentally shaped by underlying genetic mutations. By integrating multiple AD gene expression datasets with machine l...