Buyang Huanwu Decoction Alleviates Chronic Intermittent Hypoxia-Induced Myocardial Inflammation and Fibrosis via the NF- κ B/LOX Signaling Pathway [0.03%]
补阳还五汤通过NF-κB/LOX信号通路缓解慢性间歇低氧诱导的心肌炎症和纤维化
Lijun Ou,Chenyi Liu,Weicheng Zhao et al.
Lijun Ou et al.
Objective: To investigate the protective effects of Buyang Huanwu decoction (BYHW) on myocardial injury induced by chronic intermittent hypoxia (CIH) in rats and to analyze its potential regulatory mechanism through the N...
Causal Relationships Between Plasma Metabolites, Inflammatory Factors, and Oral Cancer Risk: A Comprehensive Mendelian Randomization Study With Mediation Analysis [0.03%]
血浆代谢物、炎症因素与口腔癌风险间的因果关系：一项全面的孟德尔随机化研究及中介分析
Shaonan Hu,Chufeng Liu,Minghua Ren
Shaonan Hu
This study conducted a large-scale Mendelian randomization analysis using genome-wide single nucleotide polymorphisms (SNPs) as instrumental variables to investigate the causal relationships between 1400 circulating metabolites and oral can...
Disentangling Links Between Lung Cancer and Infectious Pneumonia via Real-World Data and Integrative Genomics [0.03%]
基于真实世界数据和整合基因组学解开肺癌与肺炎的关联
Yi-Fei Diao,Zhe Chen,Yi-Fan Tang et al.
Yi-Fei Diao et al.
Lung cancer (LC) patients frequently develop infectious pneumonia, often leading to suspension of anticancer therapy, yet the impact of LC on pneumonia progression remains unclear. This study employed a multidimensional approach to investig...
Meta-Analysis
Human mutation. 2026 Jan 31:2026:4536781. DOI:10.1155/humu/4536781 2026
Exploring the Dynamic Changes of Intercellular Connections in Cervical Cancer: Insights From Transcriptomic Data Combined With Single-Cell Sequencing [0.03%]
结合转录组学数据和单细胞测序探讨宫颈癌细胞间连接的动态变化规律
Ran Ji,Rui Geng,Zhaoyue Zhang et al.
Ran Ji et al.
Background: As a common gynecological malignancy, cervical cancer has a rising incidence rate and mortality, which has brought huge pressure to global public health. Although immunotherapy has been applied in clinical pra...
Tumor Microenvironment Characterization Identifies KIF15 as an Immunosuppressive Driver in Breast Cancer [0.03%]
肿瘤微环境的特征分析揭示KIF15是乳腺癌中的免疫抑制驱动因子
Bo Zhang,Feiran Wang,Huiwei Huang et al.
Bo Zhang et al.
The various cellular composition of the tumor microenvironment (TME) comprises the fundamental units of tumor tissue. The types of stromal cells in the TME are genetically stable, with reduced risk of tumor recurrence and drug resistance. M...
Acetylated Pyrimidine Metabolism Genes as Prognostic Markers and Their Influence on Immune Profiles in Lung Adenocarcinoma [0.03%]
乙酰化嘧啶代谢基因作为肺癌预后标志物及其对免疫谱型的影响
Kegang Jia,Shuwei Zhang,Yangke He et al.
Kegang Jia et al.
Lung adenocarcinoma is a very aggressive cancer with poor clinical results. New molecular indicators are desperately needed to improve treatment decision-making. This study looks at the relationship between the immunological microenvironmen...
Revealing the Action Mechanism of Exogenous Hydrogen Sulfide Intervention in Colorectal Cancer Pathogenesis Based on Multiomics Analysis and Experimental Validation [0.03%]
基于组学分析和实验验证揭示外源性氢硫化物干预结直肠癌发病机制的作用机理
Facai Cui,Chen Yu,Weifeng Zhao et al.
Facai Cui et al.
Colorectal cancer (CRC) ranks among the leading causes of cancer-related mortality worldwide. Hydrogen sulfide (H2S) has been found to possess a characteristic of anticancer, which may offer a potential novel treatment for CRC. Here, we dis...
IPO9 Promotes Ovarian Cancer Progression by Suppressing HMOX1-Dependent Ferroptosis [0.03%]
通过抑制HMOX1依赖性铁死亡促进卵巢癌发展的IPO9
Yimei Meng,Peiling Li,Sujit Nair
Yimei Meng
Ovarian cancer (OC) poses a significant threat to women's health, with current treatment strategies remaining suboptimal, necessitating the exploration of novel therapeutic targets and immune microenvironment dynamics. This study integrates...
Exosomal lncRNA FENDRR Orchestrates Immune Remodelling and Ferroptosis in the Comorbidity of Lung Cancer and Type 1 Myocardial Infarction [0.03%]
外泌体长链非编码RNA FENDRR在肺癌和1型心肌梗死合并症中的免疫重塑及铁死亡调控作用
Youfu He,Yu Qian,Zhiwei Zheng et al.
Youfu He et al.
Lung cancer and Type 1 myocardial infarction (T1MI) increasingly co-occur, yet the molecular basis underlying their interaction remains unclear. In this study, we combined multiomics profiling, in vivo and in vitro models and human clinical...
Proprotein Convertase Subtilisin/Kexin Type 9 Induces Platelet-Derived Transforming Growth Factor- β to Promote Myocardial Fibrosis After Myocardial Infarction [0.03%]
蛋白质转化酶枯草杆菌蛋白酶/kexin亚型9通过诱导血小板源性转化生长因子-β促进心肌梗死后的心肌纤维化
Qianyun Wang,Wenxiang Huang,Dianmin Xia et al.
Qianyun Wang et al.
Aims: The recovery of cardiac function after acute myocardial infarction is crucial for the prognosis of patients with myocardial infarction. Proprotein convertase subtilisin/Kexin Type 9 (PCSK9) inhibitors are widely use...