Genomic Structural Equation Modeling Provides an Initial View of the Genetic Architecture Related to Type 1 Gaucher Disease [0.03%]
基因组结构方程模型可提供关于I型戈谢病相关遗传架构的初步观点
Shijie Ren,Mingmin Du,Jingyuan Liu et al.
Shijie Ren et al.
The genetic architecture underlying traits associated with Type 1 Gaucher disease (GD1) remains insufficiently explored. We integrated genomic structural equation modeling and multiple post-genome-wide association study (GWAS) methodologies...
Panomics Integration via Machine Learning Prioritizes TAF1D as a Therapeutic Vulnerability in Lung Adenocarcinoma [0.03%]
基于机器学习的泛组学整合分析确定TAF1D为肺腺癌治疗靶点
Lan Ding,Qingmei Xu,Dongdong Liu et al.
Lan Ding et al.
Lung adenocarcinoma (LUAD) is a leading cause of cancer mortality, necessitating the identification of robust biomarkers and a deeper understanding of its molecular underpinnings. This study is aimed at screening for potential LUAD biomarke...
Genome-Wide Cross-Trait Analysis Dissects the Shared Genetic Architecture Between Type 2 Diabetes Mellitus and Metabolic Dysfunction-Associated Steatotic Liver Disease [0.03%]
全基因组交叉性状分析解剖了2型糖尿病与代谢紊乱相关脂肪肝病之间的共有遗传结构
Zijun Zhu,Hailong Li,Xin Wang et al.
Zijun Zhu et al.
The observational studies confirmed the high prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) in patients with Type 2 diabetes mellitus (T2DM), but whether this reflects a shared genetic etiology and exists und...
Engineering of the Melanoma Inhibitor of Apoptosis (ML-IAP) Anticancer Peptide Through Comprehensive In Silico Approaches [0.03%]
基于全面的计算方法工程化黑色素瘤凋亡抑制剂(ML-IAP)抗肿瘤多肽
Haitham Ahmed Al-Madhagi,Muhammad Shahab,Zheng Guojun et al.
Haitham Ahmed Al-Madhagi et al.
Background and aims: Melanoma represents the most malignant type of skin cancer. It is estimated that approximately 100,000 new cases of melanoma were diagnosed in 2022, resulting in over 7600 deaths in the United States ...
Development of a Multiplex Amplification System Using Oxford Nanopore Sequencing for STRs and InDels [0.03%]
基于牛津纳米孔测序的多重STR和InDels富集体系研发
Wei Han,Qingzhen Zhang,Xiaochang Zhang et al.
Wei Han et al.
Nanopore sequencing has emerged as a promising technology due to its real-time data acquisition, portability, and high throughput. However, the genotyping capabilities of the latest flow cell, R10.4.1, for short tandem repeats (STRs) remain...
Integrative Multiomics and Single-Cell Analyses Identify FKBP10 as a Predictor of Radiotherapy Outcome in Colorectal Cancer [0.03%]
整合多组学和单细胞分析鉴定出FKBP10可作为结直肠癌放射治疗预后的预测因子
Fu Xinmo,Bai Minghua,Qiu Xu et al.
Fu Xinmo et al.
Background: Radiotherapy resistance limits colorectal cancer (CRC) treatment efficacy, with only 15%-20% of patients achieving a complete response. Validated biomarkers predicting treatment response and serving as therape...
Variations in DNA Repair Genes and Intratumoral Genetic Heterogeneity in Temozolomide-Resistant Glioblastoma [0.03%]
替莫唑胺耐药胶质母细胞瘤的DNA修复基因变异和肿瘤内遗传异质性
Weixuan Chen,Cong Li,Yun Liu et al.
Weixuan Chen et al.
Background: Glioblastoma (GBM) is the most prevalent primary brain tumor. Despite extensive investigations, GBM's resistance to the first-line drug temozolomide (TMZ) remains a major challenge in clinical management. This...
Assessing Allele Frequency Information: A Study of Variant Curation Expert Panel Guidelines [0.03%]
评估变异等位基因频率信息：变异解读专家小组指南研究
Xiaoyan Wang,Tongmei Zhang,Yayun Qin et al.
Xiaoyan Wang et al.
Purpose: The 2015 guidelines recommend using a large, diverse, and race-matched reference database. However, defining expectations in this context is subjective due to factors like genetic diversity and penetrance. ClinGe...
Use of Single-Cell Data and scPagwas Analysis to Identify T Cell Subsets and Construct a Prognostic Model for Clear Cell Renal Cell Carcinoma [0.03%]
利用单细胞数据和scPagwas分析鉴定透明细胞肾细胞癌T细胞亚群并构建预后模型
Xincheng Yi,Zongming Jia,Jixiang Wu et al.
Xincheng Yi et al.
Background: Clear cell renal cell carcinoma (KIRC), the most prevalent pathological renal cell carcinoma (RCC) subtype, makes up approximately 75%-84% of total cases. KIRC is characterized by high heterogeneity, high meta...
ERMP1 Exerts Tumor-Suppressive Functions in KIRC by Inhibiting PI3K/AKT Signaling and Remodeling the Immune Microenvironment: A Pan-Cancer Analysis [0.03%]
ERMP1通过抑制PI3K/AKT信号传导和重塑免疫微环境在肾透明细胞癌中发挥抑癌作用：多癌症分析结果
Ziyang Liu,Jiahao Shan,Tao Yang et al.
Ziyang Liu et al.
Background: Kidney renal clear cell carcinoma (KIRC) is an aggressive malignancy with limited therapeutic options, highlighting the need for novel biomarkers and therapeutic targets. Although endoplasmic reticulum metallo...