Paresh P Chothe,Pallabi Mitra,Masanori Nakakariya et al.
Paresh P Chothe et al.
On behalf of the team I am pleased to present the second annual 'novel insights into drug transporter sciences review' focused on peer-reviewed articles that were published in the year 2021. In compiling the articles for inclusion, preprint...
Deoxynivalenol and its modified forms: key enzymes, inter-individual and interspecies differences in metabolism [0.03%]
脱氧雪腐镰刀菌烯醇及其修饰形式：代谢关键酶、个体间和种属间的差异性代谢
Yating Wang,Jiefeng Li,Xu Wang et al.
Yating Wang et al.
Deoxynivalenol (DON) and its modified forms, including DON-3-glucoside (DON-3G), pose a major agricultural and food safety issue in the world. Their metabolites are relatively well-characterized; however, their metabolizing enzymes have not...
Diana Dimunová,Petra Matoušková,Radka Podlipná et al.
Diana Dimunová et al.
Uridine diphosphate sugar-utilizing glycosyltransferases (UGTs) are an enzyme superfamily that catalyzes glycosyl residues transfer from activated nucleotide sugars to acceptor molecules. In addition to various endogenous compounds, numerou...
Metabolism of the areca alkaloids - toxic and psychoactive constituents of the areca (betel) nut [0.03%]
.areca碱生物合成-areca(槟榔)坚果中毒性及精神活性成分
Alan L Myers
Alan L Myers
Areca nut (AN) is consumed by millions of people for its therapeutic and psychoactive effects, making it one of the most widely self-administered psychoactive substances in the world. Even so, AN use/abuse is associated with myriad oral and...
Impact of DNA methylation on ADME gene expression, drug disposition, and efficacy [0.03%]
DNA甲基化对药物代谢动力学/药物代谢酶和转运蛋白基因表达、药代性质及疗效影响的作用机制研究
Xu Hao,Yuanyuan Li,Jialu Bian et al.
Xu Hao et al.
Interindividual differences in drug response have always existed in clinical treatment. Genes involved in drug absorption, distribution, metabolism, and excretion (ADME) play an important role in the process of pharmacokinetics. The effects...
In vitro cell-based models of drug-induced hepatotoxicity screening: progress and limitation [0.03%]
药物诱导肝毒性筛选的体外细胞模型研究：进展与局限性
Maryam Mirahmad,Reyhaneh Sabourian,Mohammad Mahdavi et al.
Maryam Mirahmad et al.
Drug-induced liver injury (DILI) is one of the major causes of post-approval withdrawal of therapeutics. As a result, there is an increasing need for accurate predictive in vitro assays that reliably detect hepatotoxic drug candidates while...
The multifaceted role of cytochrome P450-Derived arachidonic acid metabolites in diabetes and diabetic cardiomyopathy [0.03%]
细胞色素P450衍生的花生四烯酸代谢物在糖尿病和糖尿病心肌病中的作用
Fadumo Ahmed Isse,Ahmed A El-Sherbeni,Ayman O S El-Kadi
Fadumo Ahmed Isse
Understanding lipid metabolism is a critical key to understanding the pathogenesis of Diabetes Mellitus (DM). It is known that 60-90% of DM patients are obese or used to be obese. The incidence of obesity is rising owing to the modern seden...
Regulation of human UDP-glycosyltransferase (UGT) genes by miRNAs [0.03%]
人UDP-葡萄糖基转移酶(UGT)基因的miRNA调节机制研究进展
Dong Gui Hu,Peter I Mackenzie,Julie-Ann Hulin et al.
Dong Gui Hu et al.
The human UGT gene superfamily is divided into four subfamilies (UGT1, UGT2, UGT3 and UGT8) that encodes 22 functional enzymes. UGTs are critical for the metabolism and clearance of numerous endogenous and exogenous compounds, including ste...
Implication of metabolomics and transporter modulation based strategies to minimize multidrug resistance and enhance site-specific bioavailability: a needful consideration toward modern anticancer drug discovery [0.03%]
基于代谢组学和转运体调节策略的多药耐药最小化及特异性靶区生物利用度增强的作用机制：现代抗癌药物发现中亟待考虑的问题
Megha Rachmale,Niraj Rajput,Tarang Jadav et al.
Megha Rachmale et al.
Induction of drug-metabolizing enzymes and efflux transporters (DMET) through activation of pregnane x receptor (PXR) is the primary factor involved in almost all bioavailability and drug resistance-related problems of anticancer drugs. PXR...
Through a glass, darkly? HepaRG and HepG2 cells as models of human phase I drug metabolism [0.03%]
隔着窗户，迷茫吗？HepaRG和HepG2细胞作为人类I相药物代谢模型的研究进展
Lesley A Stanley,C Roland Wolf
Lesley A Stanley
The pharmacokinetic and safety assessment of drug candidates is becoming increasingly dependent upon in vitro models of hepatic metabolism and toxicity. Predominant among these is the HepG2 cell line, although HepaRG is becoming increasingl...