Bin Ma,Lionel Cheruzel,Sungjoon Cho et al.
Bin Ma et al.
New drug modalities (NDMs) continue to redefine the pharmaceutical landscape by addressing "undruggable" targets and providing innovative therapeutics for various diseases. This third annual review summarizes 15 selected publications from 2...
Simplified approaches to kinetic isotope effects in cytochrome P450-catalyzed reactions and relevance to deuterated drugs [0.03%]
细胞色素P450催化反应中的动能同位素效应的简化方法及其与氘代药物的相关性
F Peter Guengerich
F Peter Guengerich
Kinetic isotope effects (KIEs) have been used to study mechanisms of cytochrome P450 (P450, CYP) reactions and are the basis of most applications for deuterated drugs. However, the complexity of KIEs has led to limited use and to some erron...
A review on Analytical Perspectives for Cyclophosphamide, Its Metabolites, and Impurities [0.03%]
环磷酰胺及其代谢物和杂质的分析透视研究综述
Harshal Ahirrao,Hemant Kumar Tatapudi,Kishore Raju Vatsavai
Harshal Ahirrao
Cyclophosphamide (CP) is a common chemotherapeutic and immunosuppressive drug whose investigation is important due to its biotransformation, toxic breakdown products, and potential for environmental pollution. The purpose of this review is ...
Redox Enzyme Networks Shaping Cancer Drug Metabolism and Therapeutic Resistance [0.03%]
红氧酶网络塑造癌症药物代谢和治疗抵抗性
Başak Gökçe,Şeyma Rana Karakaş
Başak Gökçe
Multidrug resistance remains a major challenge in cancer therapy, arising from complex adaptive mechanisms that enable tumor cells to survive pharmacological stress. Among these mechanisms, redox-regulating enzymes play a pivotal role by ma...
A Critical Review of Analytical Tools for the Detection of Spironolactone and Its Metabolites [0.03%]
spironolactone及其代谢物检测分析工具批判性 review
Hemn A H Barzani,Rebaz Anwar Omer,Khalamala Ibrahim Salih Barzani et al.
Hemn A H Barzani et al.
Spironolactone (SPI) is a synthetic aldosterone antagonist steroid used to treat various conditions, including hypertension, heart failure, primary hyperaldosteronism, and androgen-related disorders. SPI undergoes extensive hepatic metaboli...
How gut microbiota modulate anesthetic drug response and perioperative outcomes [0.03%]
肠道微生物群如何调节麻醉药物反应和围手术期结局
Dawei Wang
Dawei Wang
The pursuit of precision in anesthesiology is persistently challenged by profound and unpredictable inter-patient variability in drug response. While pharmacogenomics has provided critical insights, a significant portion of this variability...
Molecular Insights into Doxorubicin-Induced Cardiotoxicity and Phytochemical-Based Cardioprotection: Challenges and Future Strategies [0.03%]
基于植物化学物质的心肌保护的多柔比星致心毒性分子机理研究：挑战和未来策略
Mukul Shyam,Amrutha M,Niharika Kommoju et al.
Mukul Shyam et al.
Doxorubicin, an anthracycline antibiotic extensively used in cancer treatment, is limited by its dose-dependent cardiotoxicity caused by oxidative stress, mitochondrial dysfunction, inflammation, and cardiomyocyte apoptosis-ultimately leadi...
Review on the Application of Metalloporphyrin Catalysts as Cytochrome P450 Enzyme Mimics in Biomimetic Modeling [0.03%]
金属卟啉催化剂模拟细胞色素P450酶在仿生模体中应用的研究进展
Ahmed Qasim Abdulhussein,Diána Balogh-Weiser,Balázs Volk et al.
Ahmed Qasim Abdulhussein et al.
Drug research, particularly in the early discovery phase, increasingly seeks cost-effective and reliable in vitro models to predict drug metabolism. Metalloporphyrins (MPs), due to their structural and functional resemblance to the heme gro...
Relevance of Reactive Metabolites and Covalent Binding to Drug Candidate Selection [0.03%]
反应性代谢物与共价结合在候选药物选择中的作用
Jack Uetrecht
Jack Uetrecht
Idiosyncratic drug reactions (IDRs)represent a major risk for drug development. Current methods do not reliably predict IDR risk. There is strong evidence that most IDRs are immune-mediated. An adaptive immune response requires 2 signals: s...
Rasha A Guneidy
Rasha A Guneidy
Chemoresistance remains a major barrier in cancer therapy, frequently resulting in treatment failure and reduced patient survival. This multifaceted phenomenon arises from the interplay of well-established mechanisms such as genetic mutatio...