A Critical Review of Analytical Tools for the Detection of Spironolactone and Its Metabolites [0.03%]
spironolactone及其代谢物检测分析工具批判性 review
Hemn A H Barzani,Rebaz Anwar Omer,Khalamala Ibrahim Salih Barzani et al.
Hemn A H Barzani et al.
Spironolactone (SPI) is a synthetic aldosterone antagonist steroid used to treat various conditions, including hypertension, heart failure, primary hyperaldosteronism, and androgen-related disorders. SPI undergoes extensive hepatic metaboli...
How gut microbiota modulate anesthetic drug response and perioperative outcomes [0.03%]
肠道微生物群如何调节麻醉药物反应和围手术期结局
Dawei Wang
Dawei Wang
The pursuit of precision in anesthesiology is persistently challenged by profound and unpredictable inter-patient variability in drug response. While pharmacogenomics has provided critical insights, a significant portion of this variability...
Molecular Insights into Doxorubicin-Induced Cardiotoxicity and Phytochemical-Based Cardioprotection: Challenges and Future Strategies [0.03%]
基于植物化学物质的心肌保护的多柔比星致心毒性分子机理研究：挑战和未来策略
Mukul Shyam,Amrutha M,Niharika Kommoju et al.
Mukul Shyam et al.
Doxorubicin, an anthracycline antibiotic extensively used in cancer treatment, is limited by its dose-dependent cardiotoxicity caused by oxidative stress, mitochondrial dysfunction, inflammation, and cardiomyocyte apoptosis-ultimately leadi...
Review on the Application of Metalloporphyrin Catalysts as Cytochrome P450 Enzyme Mimics in Biomimetic Modeling [0.03%]
金属卟啉催化剂模拟细胞色素P450酶在仿生模体中应用的研究进展
Ahmed Qasim Abdulhussein,Diána Balogh-Weiser,Balázs Volk et al.
Ahmed Qasim Abdulhussein et al.
Drug research, particularly in the early discovery phase, increasingly seeks cost-effective and reliable in vitro models to predict drug metabolism. Metalloporphyrins (MPs), due to their structural and functional resemblance to the heme gro...
Relevance of Reactive Metabolites and Covalent Binding to Drug Candidate Selection [0.03%]
反应性代谢物与共价结合在候选药物选择中的作用
Jack Uetrecht
Jack Uetrecht
Idiosyncratic drug reactions (IDRs)represent a major risk for drug development. Current methods do not reliably predict IDR risk. There is strong evidence that most IDRs are immune-mediated. An adaptive immune response requires 2 signals: s...
Rasha A Guneidy
Rasha A Guneidy
Chemoresistance remains a major barrier in cancer therapy, frequently resulting in treatment failure and reduced patient survival. This multifaceted phenomenon arises from the interplay of well-established mechanisms such as genetic mutatio...
Pregnane X Receptor (PXR/NR1I2): Linking Drug Metabolism, Bile Acid Detoxification, and Cholesterol Homeostasis [0.03%]
孕烷X受体(PXR/NR1I2)与药物代谢、胆汁酸解毒和胆固醇稳态之间的联系
Nila Ganamurali,Sarvesh Sabarathinam
Nila Ganamurali
Pregnane X receptor (PXR; NR1I2) is a promiscuous ligand-activated nuclear receptor traditionally recognized as a master regulator of xenobiotic detoxification. Beyond xenobiotic detoxification, emerging evidence implicates PXR as a pivotal...
CYP24A1: The Pivotal Regulator of Vitamin D Homeostasis, Pathophysiology in Metabolic and Genetic Disease, and Emerging Target for Precision Medicine [0.03%]
CYP24A1维生素D稳态的关键调节因子及其在代谢和遗传性疾病中的病理生理作用和作为精准医学新兴靶点的作用
NavodiSandamini Jayathilaka,Weththasinghe A V,Wijekoon D M K J et al.
NavodiSandamini Jayathilaka et al.
CYP24A1 (25-hydroxyvitamin D3 24-hydroxylase) functions as the essential catabolic "off-switch" of the vitamin D endocrine axis. As a mitochondrial cytochrome P450 enzyme, it tightly regulates calcitriol (1,25(OH)2D3) levels through a remar...
Role of Herbal Extracts in Modulating Drug Metabolism: Implications for Pharmacokinetics, Enzyme Regulation, and Therapeutic Outcome [0.03%]
herbal extracts在调节药物代谢中的作用：对药代动力学、酶调控和治疗效果的影响
Alina Khan,Gadah Abdulaziz Al-Hamoud,Musarat Amina et al.
Alina Khan et al.
Herbal medicines are widely used worldwide, often alongside prescription drugs, creating the potential for clinically significant herb-drug interactions. These interactions are frequently mediated by effects on drug-metabolizing enzymes, pa...
Pharmacokinetic considerations and strategies for antibody-based therapeutics [0.03%]
抗体药物的药代动力学考虑和策略
Juanhong Zhang,Rong Chang,Anpeng Zhao et al.
Juanhong Zhang et al.
Antibody-based therapeutics are specifically designed to bind to antigens, thereby facilitating the treatment of various diseases, including tumors and autoimmune disorders, resulting in significant therapeutic effects. Notably, the therape...