Herbal Supplements and Anti-Tuberculosis Therapy: Unlocking Hidden Interactions for Better Multidrug-Resistant Tuberculosis Management [0.03%]
中药与抗结核治疗：解锁隐藏的相互作用以更好地管理耐多药结核病
Siva Bhukya,Ravi Adinarayan Somabattini,Neelanjan Chowdhury et al.
Siva Bhukya et al.
Tuberculosis (TB), especially in its multidrug-resistant form (MDR-TB), remains a persistent threat to global health despite decades of medical advancements. Standard treatment regimens often involve complex drug combinations, which, while ...
Identification and characterization of a novel aldehyde metabolite of WIN18,446 and associated WIN18,446-ALDH1A2 protein adducts using mass spectrometry [0.03%]
利用质谱技术鉴定和表征WIN18,446的新醛代谢物及其相关蛋白加合物(WIN18,446-ALDH1A2)
Alex Zelter,Guo Zhong,Michal Maes et al.
Alex Zelter et al.
ALDH1A family enzymes (ALDH1A1, ALDH1A2, and ALDH1A3) catalyze retinoic acid synthesis, and their dysregulation is linked to disease. Selective inhibitors of these enzymes have been tested in drug discovery programs and one such compound, W...
Pharmacomicrobiomics in Precision Pharmacotherapy: Bidirectional Microbial-Drug Interactions as a Key Determinant of Therapeutic Response [0.03%]
精准药物治疗中的药理微生物组学：双向菌药互作决定药物疗效的关键因素
Serap Yalçın Azarkan,Habibe Sema Arslan Ünal,Sevinç Akçay
Serap Yalçın Azarkan
Interindividual variability in drug efficacy and toxicity remains a major challenge in clinical pharmacotherapy. Although pharmacogenomics has substantially advanced personalized medicine, host genetic variation alone cannot fully explain d...
Yifan Ding,Xianghai Zeng,Jing Zou et al.
Yifan Ding et al.
Levofloxacin is an effective anti-infective agent for the treatment of infectious diseases. However, the marked interindividual variability in levofloxacin pharmacokinetics across differentpopulations introduces uncertainty regarding its cl...
Exploring the clinical pharmacokinetics and pharmacodynamics of SGLT2 inhibitor, empagliflozin: a systematic review [0.03%]
恩格列净临床药动学和药效学研究的系统评价
Tahir Saleem,Muhammad Fawad Rasool,Hamid Saeed et al.
Tahir Saleem et al.
Empagliflozin is a potent, highly selective antihyperglycemic agent indicated for the treatment of adults with type 2 diabetes mellitus. This review aims to evaluate the pharmacokinetic (PK) and pharmacodynamic (PD) parameters of empagliflo...
Extracellular Vesicles as Xenobiotic-Metabolizing Enzyme Carriers: A New Paradigm for Brain Drug Metabolism [0.03%]
细胞外囊泡作为异种生物代谢酶载体：脑药物代谢的新范式
Veena V Tom,Ann Mary Jose,Athira Sasidharan et al.
Veena V Tom et al.
Emerging evidence suggests hepatocyte-derived extracellular vesicles (hd-EVs) may transport drug-metabolizing enzymes across the BBB. This liver-brain metabolic axis remains a conceptual model that requires in vivo validation of localized b...
Cytochrome P450-Derived Arachidonic Acid Metabolites as Emerging Therapeutic Targets in Menopause-Associated Cardiac Hypertrophy [0.03%]
细胞色素P450衍生的花生四烯酸代谢物作为治疗与更年期相关的心脏肥厚的新靶点
Mostafa K Abd El-Aziz,Ali H Shalaby,Sara R El-Mahrouk et al.
Mostafa K Abd El-Aziz et al.
Menopause is associated with a marked increase in cardiac hypertrophy and progression to heart failure with preserved ejection fraction (HFpEF), a condition that disproportionately affects women and lacks effective targeted therapies. Altho...
Lionel Cheruzel,Upendra A Argikar,Pietro Brunetti et al.
Lionel Cheruzel et al.
Metabolism of new drug modalities research advances - 2025 year in review [0.03%]
新型药物代谢研究进展盘点——2025年度回顾
Bin Ma,Lionel Cheruzel,Sungjoon Cho et al.
Bin Ma et al.
New drug modalities (NDMs) continue to redefine the pharmaceutical landscape by addressing "undruggable" targets and providing innovative therapeutics for various diseases. This third annual review summarizes 15 selected publications from 2...
Simplified approaches to kinetic isotope effects in cytochrome P450-catalyzed reactions and relevance to deuterated drugs [0.03%]
细胞色素P450催化反应中的动能同位素效应的简化方法及其与氘代药物的相关性
F Peter Guengerich
F Peter Guengerich
Kinetic isotope effects (KIEs) have been used to study mechanisms of cytochrome P450 (P450, CYP) reactions and are the basis of most applications for deuterated drugs. However, the complexity of KIEs has led to limited use and to some erron...