Pharmacokinetic considerations and strategies for antibody-based therapeutics [0.03%]
抗体药物的药代动力学考虑和策略
Juanhong Zhang,Rong Chang,Anpeng Zhao et al.
Juanhong Zhang et al.
Antibody-based therapeutics are specifically designed to bind to antigens, thereby facilitating the treatment of various diseases, including tumors and autoimmune disorders, resulting in significant therapeutic effects. Notably, the therape...
Phase II Metabolism in Xenobiotic Biotransformation: General Mechanisms and the Underestimated Role of Microbial Systems [0.03%]
外来化合物生物转化中的二期代谢：一般机制及其微生物系统的 underestimated 作用
Aleksandra Pietrzak,Barbara Dąbrówka,Justyna Popiół et al.
Aleksandra Pietrzak et al.
Microbial phase II biotransformation, involving conjugation reactions such as glycosylation, sulfation, and glucuronidation, is increasingly recognized as a valuable in vitro model for mammalian xenobiotic metabolism, particularly drug meta...
Cunzhen Zhang,Yan Fang,Lin Jia et al.
Cunzhen Zhang et al.
Cytochrome P450 (CYP450) enzymes play a crucial role in drug metabolism, and their content and activity are important parameters in pharmacokinetic studies. However, due to variations in sample size, background information, and detection me...
Multimolecular interactions from Chinese medicines activate nuclear receptor conformational changes: a potential strategy for anti-inflammatory therapy [0.03%]
中药多分子间相互作用可激活核受体构象改变：抗炎治疗的新策略
Xuechun Yu,Ying Zhang,Bingxin Wu et al.
Xuechun Yu et al.
Nuclear receptors (NRs) are among the most common transcriptional regulators in the human body. Currently, liver X receptor (LXR), pregnane X receptor (PXR), farnesoid X receptor (FXR), and peroxisome proliferator-activated receptor (PPAR) ...
Analytical Techniques for Methyldopa and Metabolites: A Comprehensive Review [0.03%]
甲基多巴及其代谢产物的分析技术：综述
Hemn A H Barzani,Seerwan Hamadameen Sulaiman,Rebaz Anwar Omer et al.
Hemn A H Barzani et al.
Methyldopa, a centrally acting α2-adrenergic agonist, remains a key antihypertensive drug, particularly prescribed for pregnant and renal-impaired patients. Its clinical significance has led to extensive research aimed at developing reliab...
Robert S Foti
Robert S Foti
Cyclodextrins grafted magnetite (Fe3O4) nanocarriers for anticancer therapy [0.03%]
用于癌症治疗的接枝有磁铁矿（Fe3O4）纳米载体的环糊精
Sivakumar Krishnamoorthy,Divya Annaparvathi Suyamburaj
Sivakumar Krishnamoorthy
This comprehensive review explores the therapeutic promise of cyclodextrin-grafted magnetite (Fe3O4) nanocarriers in anticancer applications, focusing on their design, drug delivery mechanisms, biological stability, and therapeutic performa...
Insights into CYP450 Polymorphisms and Their Impact on Drug Metabolism in Alzheimer's Disease Therapy [0.03%]
CYP450多态性在阿尔茨海默病治疗中的研究及其对药物代谢的影响
Jingjing Zheng,Guoqing Liu,Qi Wang et al.
Jingjing Zheng et al.
Alzheimer's disease (AD) is a complex neurodegenerative disorder that poses significant therapeutic challenges. Currently available treatments offer symptomatic relief but often yield suboptimal outcomes due to inter-individual variability ...
Correction [0.03%]
改正错误
Published Erratum
Drug metabolism reviews. 2025 Aug 28:1. DOI:10.1080/03602532.2025.2552600 2025
Metabolism of New Drug Modalities Research Advances - 2024 year in review [0.03%]
新型药物代谢研究进展——2024年回顾
Bin Ma,Upendra A Argikar,Luying Chen et al.
Bin Ma et al.
New drug modalities (NDMs) have gained significant popularity and attention in recent years due to their ability to target previously undruggable pathways and offer new strategies for tackling complex diseases. This trend is reflected in ou...