Melatonin in cancer biology: pathways, derivatives, and the promise of targeted delivery [0.03%]
褪黑素在癌症生物学中的作用：途径，衍生物和靶向给药的前景
Yu-Juan Yi,Hong Tang,Peng-Lai Pi et al.
Yu-Juan Yi et al.
Melatonin, historically recognized for its primary role in regulating circadian rhythms, has expanded its influence particularly due to its wide range of biological activities. It has firmly established itself in cancer research. To highlig...
The potential impact of CYP and UGT drug-metabolizing enzymes on brain target site drug exposure [0.03%]
细胞色素P450和尿苷二磷酸葡萄糖醛酸转移酶药物代谢酶对脑靶向药物暴露的潜在影响
Mengxu Zhang,Vivi Rottschäfer,Elizabeth C M de Lange
Mengxu Zhang
Drug metabolism is one of the critical determinants of drug disposition throughout the body. While traditionally associated with the liver, recent research has unveiled the presence and functional significance of drug-metabolizing enzymes (...
Rajeswara Babu Mythri,Mysore Rajeswara Babu Aishwarya
Rajeswara Babu Mythri
The brain is a privileged organ, tightly guarded by a network of endothelial cells, pericytes, and glial cells called the blood brain barrier. This barrier facilitates tight regulation of the transport of molecules, ions, and cells from the...
Nida Hanif,Ammara Zamir,Imran Imran et al.
Nida Hanif et al.
Nebivolol is a beta-1 receptor blocker used to treat hypertension, heart failure, erectile dysfunction, vascular disease, and diabetes mellitus. This review investigated the data regarding pharmacokinetic (PK) parameters, drug-drug interact...
S Cyrus Khojasteh,Upendra A Argikar,Lionel Cheruzel et al.
S Cyrus Khojasteh et al.
This annual review is the eighth of its kind since 2016 (Baillie et al. 2016, Khojasteh et al. 2017, Khojasteh et al. 2018, Khojasteh et al. 2019, Khojasteh et al. 2020, Khojasteh et al. 2021, Khojasteh et al. 2022). Our objective is to exp...
Differential modulation of cytochrome P450 enzymes by arsenicals in non-human experimental models [0.03%]
砷化物对非人类实验模型中细胞色素P450酶的差异调节作用
Mahmoud A El-Ghiaty,Sara R El-Mahrouk,Mohammed A Alqahtani et al.
Mahmoud A El-Ghiaty et al.
Arsenic is a hazardous heavy metalloid that imposes threats to human health globally. It is widely spread throughout the environment in various forms. Arsenic-based compounds are either inorganic compounds (iAs) or organoarsenicals (oAs), w...
Paresh P Chothe,Pallabi Mitra,Masanori Nakakariya et al.
Paresh P Chothe et al.
On behalf of all the authors, I am pleased to share our third annual review on drug transporter science with an emphasis on articles published and deemed influential in signifying drug transporters' role in drug disposition in the year 2022...
Shuai Wang,Upendra A Argikar,Lionel Cheruzel et al.
Shuai Wang et al.
With the 50th year mark since the launch of Drug Metabolism and Disposition journal, the field of drug metabolism and bioactivation has advanced exponentially in the past decades (Guengerich 2023).This has, in a major part, been due to the ...
New strategy for rational use of antihypertensive drugs in clinical practice in high-altitude hypoxic environments [0.03%]
高原低氧环境高血压患者合理用药的临床策略
Delong Duo,Yabin Duan,Junbo Zhu et al.
Delong Duo et al.
High-altitude hypoxic environments have critical implications on cardiovascular system function as well as blood pressure regulation. Such environments place patients with hypertension at risk by activating the sympathetic nervous system, w...
Pregnane X receptor as a therapeutic target for cholestatic liver injury [0.03%]
孕烷X受体在胆汁淤积性肝损伤治疗中的作用与机制研究进展
Huan Lan,Ying Zhang,Minqi Fan et al.
Huan Lan et al.
Cholestatic liver injury (CLI) is caused by toxic bile acids (BAs) accumulation in the liver and can lead to inflammation and liver fibrosis. The mechanisms underlying CLI development remain unclear, and this disease has no effective cure. ...